High Content Analysis and Screening for Drug Discovery
An automated real-time confocal microscope system which includes a pipetting system is available to rapidly screen for the dynamic actions of drug candidates in live cell models using batteries of assays for messenger and other cellular processes.
3D Confocal Microscopy
Systems are available for high resolution confocal 3D imaging and reconstruction of images from multiple fluorescent probes for co-localization of antibodies and other cellular probes in fixed and live cell specimens. The instruments in the Center are state-of-the-art direct viewing real-time confocal microscopes that make obtaining a confocal image as easy as using a standard microscope.
Scanning Electron Microscopy
A JEOL JSM-35 scanning electron microscope is available at the Center for multi-purpose high resolution (60 Angstrom) scanning of specimen.
Image Analysis
A variety of software packages are available to analyze images obtained from the microscopes.
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Assay Development and Consultation
Help with designing and setting up assays for new targets is available.
Cell Culture
Facilities are available for passing cells and maintaining them for live cell imaging experiments.
Microinjection
Equipment and facilities are available for injection of fluorescent dyes, proteins, and small molecules into cells during real-time fluorescent microscopic observation for fluorescence or FRET.
Fluorescence Spectroscopy
Equipment for measuring the fluorescence excitation and emission spectra of fluorescent dyes is available to optimize microscopic conditions.
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