Publications

Shimura T., Martin M, Torres MJ, Gu C, DeBernardi M.A., Mc Donald SJ and Aladiem MI. (2007) DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication.  J Mol Biol  - 367 (3); 665-680.

DeBernardi M.A., Hewitt SM and Kriete A. (2006) Automated confocal imaging and high-content screening for cytomics. in: Handbook of Biological Confocal Microscopy, 3rd Edition, pp. 818-828    Editor: Jim Pawley, Springer Science

DeBernardi M.A and Brooker, G. (2006) High content kinetic calcium imaging in drug sensitive and drug resistant human breast cancer cells. In Methods in Enzymology, Measurements of Biological Responses Using Automated Microscopy Editor: J. Inglese, Vol. 414, pp 317-335; Elsevier, San Diego, CA

Nosheny, R.L., Bachis, A., Aden, S., DeBernardi, M.A. and Mocchetti, I.  (2006) Intrastriatal administration of Human Immunodeficiency Virus – 1 glycoprotein 120 reduces glial cell line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. J. of Neurobiology;  66(12):1311-21

Bachis A., Colangelo A.M., Vicini S., Doe P.P., DeBernardi M.A., Brooker G. and Mocchetti I.: Interleukin –10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3 like activity.  J. Neurosci. 21: 3104-3112, 2001

DeBernardi M.A. and Brooker G.: Simultaneous fluorescence ratio imaging of cyclic AMP and calcium kinetics in single living cells. in: Advances in 2nd messengers and phosphoprotein research, Vol. 32, Cooper D.M.F. Editor, Lippincott-Raven, Philadelphia, pp. 195-213, 1998

Brandoli C., Sanna A., DeBernardi M.A., Follesa P., Brooker G. and Mocchetti, I.: Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells.  J. Neurosci 18(19): 7953-7961, 1998

DeBernardi M.A. and Brooker G.:  Single cell Ca2+/cAMP cross-talk monitored by simultaneous Ca2+/cAMP fluorescence ratio imaging. Proc. Natl. Acad. Sci. USA 93:4577-4582, 1996

DeBernardi M.A., Rabin S.J., Colangelo A.M., Brooker G. and Mocchetti I.:  trkA mediates the nerve growth factor-induced intracellular calcium accumulation. J. Biol. Chem. 271:6092-6098, 1996

DeBernardi M.A., Munshi R., Yoshimura M., Cooper D.M.F. and Brooker G.: Predominant expression of type VI adenylate cyclase in C6-2B rat glioma cells may account for inhibition of cAMP accumulation by calcium. Biochem. J. 295:325-328, 1993

Munshi R, DeBernardi M.A. and Brooker G.: P2U receptors on C6-2B rat glioma cells: modulation of cytosolic Ca2+ and cAMP levels by protein kinase C. Mol. Pharmacol. 44:1185-1191, 1993

DeBernardi, M.A., Munshi, R., and Brooker, G. Ca2+ Inhibition of Beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C. Mol. Pharmacol. 43:451-458, 1993

DeBernardi M.A. and Brooker G.: 2-Aminopurine inhibits RNA and protein synthesis and reduces catecholamine desensitization in C6-2B rat glioma cells.  FEBS Lett.  296: 112-116, 1992

Mocchetti I., DeBernardi M.A. and Fabrazzo M.: Toward the pharmacological regulation of nerve growth factor biosynthesis. in: Cholinergic basis for Alzheimer therapy., Becker N. and Giacobini E. (eds). Birkhauser, Boston, pp. 453-459, 1991

DeBernardi M.A., Seki T. and Brooker G.: Inhibition of cyclic AMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA. Proc. Natl. Acad. Sci. USA 88:9257-9261, 1991

DeBernardi M.A., Fabrazzo M. and Mocchetti I.: Transcriptional regulation of nerve growth factor gene.  in: Neurotransmitter regulation of gene transcription., Costa E. and Joh T.H. (eds). Vol.7, Thieme, N.Y., pp. 37-46, 1991

Bathia K., Cherney B., Huppi K., Magrath I., Cossman J, Sausville E., Barriga F., Johnson B., Gause B., Bonney G., Neequavy J., DeBernardi M.A. and Smulson M.: A deletion linked to a Poly(ADP-ribose) polymerase gene on chromosome 13q33-qter occurs frequently in the normal black population as well in tumor DNA.  Cancer Res.  50: 5406-5413, 1990

Yakovlev A.G., DeBernardi M.A., Fabrazzo M., Brooker G., Costa E., and Mocchetti I.: Regulation of nerve growth factor receptor mRNA content by dexamethasone: In vitro and in vivo studies.  Neurosci. Letts. 116:216-220, 1990

Mocchetti I., Dal Toso R., Yakovlev A.G., DeBernardi M.A. and Fabrazzo M.: Regulation of NGF gene expression: in vitro and in vivo studies. in: Trophic factor and the nervous system., Horrocks, G., Neff, N., Yates A.J., Hadjiconstantinou M. (eds). Raven Press, N.Y., pp. 85-94, 1990

Mocchetti I., DeBernardi M.A., Szekely A.M., Alho H., Brooker G. and Costa E.: Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein.  Proc. Natl. Acad. Sci. U.S.A. 86: 3891-3895, 1989

DeBernardi M.A., Crowe R.R., Mocchetti I., Shows T.B., Eddy R.L. and Costa E.: Chromosomal localization of the human Diazepam Binding Inhibitor gene.  Proc. Natl. Acad. Sci. U.S.A. 85: 6561-6565, 1988

Dal Toso R., DeBernardi M.A., Brooker G., Costa E. and Mocchetti I.: Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells.  J. Pharmacol. Exp. Ther.  246: 1190-1193, 1988

Dal Toso R., DeBernardi M.A., Costa E. and Mocchetti I.: Beta-adrenergic receptor regulation of NGF-mRNA content in rat C2-2B glioma cells.  Neuropharmacology 26, 12: 1783-1786, 1987

DeBernardi M.A. and Brooker G.: Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.  Proc. Natl. Acad. Sci. U.S.A.  84: 2246-2250, 1987

DeBernardi M.A. Stagni F., and Lampertico P.: Observation on a case of human ovary carcinoma cultured in vitro. Istocitopatologia 6: 83-86, 1984  (italian)

Stagni F., Lampertico P. and DeBernardi M.A.: Receptor status of human breast multiple tumors in metastasis. Istocitopatologia 6: 63-66, 1984  (italian)

DeBernardi M.A Stagni F, and Lampertico P.: Histochemistry methods for the determination of estrogen and progesterone receptors in human breast tumors. Istocitopatologia 6: 11-16, 1984  (italian)

US Patents
Pub. No.: US 2004/0110244A1 June 10, 2004 Methods for Diagnosing Drug-Resistant Cancer Cells or for Identifying Chemotherapeutic Agents by Measuring Anomalous Intracellular Ion and/or Second Messenger Dynamics