Publications

Espenshade, PJ on PubMed

  • Sehgal, A, Hughes, B.T., Espenshade, P.J. 2008. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Research: doi: 10.1093/nar/gkn027. [pdf]
  • Sehgal, A., C.Y. Lee, P.J. Espenshade. 2007. SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast. PLoS Genet. 3:e131 [pdf].
  • Espenshade, P.J., A.L. Hughes. 2007. Regulation of sterol synthesis in eukaryotes. Annu. Rev. Genet. 2007 Jul 31; [pdf].
  • Lee, H., C.M. Bien, A.L. Hughes, P.J. Espenshade, K.J. Kwon-Chung. 2007. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Mol. Microbiol. 65:1018-1033. [pdf]
  • Hughes, A.L., C.Y. Lee, C.M. Bien, P.J. Espenshade. 2007. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. J. Biol. Chem. 282:24388-96. [pdf]
  • Chang, Y.C., C.M. Bien, H. Lee, P.J. Espenshade, K.J. Kwon-Chung. 2007. Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Mol. Microbiol. 64:614-29. [pdf]
  • Hughes, A.L., D.W. Powell, M. Bard, J. Eckstein, R. Barbuch, A.J. Link, and P.J. Espenshade. 2007. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metabolism 5:143-149. [pdf]
  • Todd, B.L., E.V. Stewart, J.S. Burg, A.L. Hughes, P.J. Espenshade. 2006. SREBP is a principal regulator of anaerobic gene expression in fission yeast. Mol. Cell. Biol. 26:2817-2831. [pdf]
  • Espenshade, P.J. SREBPs: sterol-regulated transcription factors. 2006. J. Cell Sci. 119:973-976. [pdf]
  • Hughes, A.L., B.L. Todd, and P.J. Espenshade. 2005. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120:831-842. [pdf]
  • Espenshade, P.J., J.L. Goldstein, and M.S. Brown. 2003. “SREBPs: Gene Regulation through Controlled Protein Trafficking”. In Handbook of Cellular Signaling (R. Bradshaw and E. Dennis, eds.). Academic Press, San Diego.
  • Espenshade, P.J., W.P. Li, D. Yabe. 2002. Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. PNAS 99:11694-11699. [pdf]
  • Yang, T., P.J. Espenshade, M.E. Wright, D. Yabe, Y. Gong, R. Aebersold, J.L. Goldstein, and M.S. Brown. 2002. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in the ER. Cell 110:489-500. [pdf]
  • Nohturfft, A., D. Yabe, J.L. Goldstein, M.S. Brown, and P.J. Espenshade. 2000. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell 102:315-323. [pdf]
  • DeBose-Boyd R.A., M.S. Brown, W.P. Li, A. Nohturfft, J.L. Goldstein, P.J. Espenshade. 1999. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99:703-712. [pdf]
  • Espenshade, P.J., D. Cheng, J.L. Goldstein, and M.S. Brown. 1999. Autocatalytic processing of Site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. J. Biol. Chem. 274:22795-22804. [pdf]
  • Cheng, D., P.J. Espenshade, C.A. Slaughter, M.S. Brown, and J.L. Goldstein. 1999. Secreted Site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory-element binding proteins. J. Biol. Chem. 274:22805-22812. [pdf]
  • Roberg, K.J., M. Crotwell, P. Espenshade, R. Gimeno, and C.A. Kaiser. 1999. LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the ER. J. Cell Biol. 145:659-672. [pdf]
  • Sakai, J., R.B. Rawson, P. Espenshade, D. Cheng, A.C. Seegmiller, J.L. Goldstein, and M.S. Brown. 1998. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell. 2:505-514. [pdf]
  • Shaywitz, D.A., P. Espenshade, R.E. Gimeno, and C.A. Kaiser. 1997. COPII subunit interactions in the assembly of the vesicle coat. J. Biol. Chem. 272:25413-25416. [pdf]
  • *Gimeno, R.E., *P. Espenshade, and C.A. Kaiser. 1996. COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p. Mol. Biol. Cell 7:1815-1823. *These authors contributed equally to the experiments in this paper. [pdf]
  • Espenshade, P., R.E. Gimeno, E. Holzmacher, P. Teung, and C.A. Kaiser. 1995. Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. J. Cell Biol. 131:311-324. [pdf]
  • R.E. Gimeno, P. Espenshade, and C.A. Kaiser. 1995. SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation. J. Cell Biol. 131:325-338. [pdf]
  • Berberich, S., N. Hyde-DeRuyscher, P. Espenshade, and M. Cole. 1992. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. Oncogene 7:775-779.