Selected Publications from the Roth Group

Reprints and preprints are available upon request-- jproth@jhu.edu .

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18. "Concerted and Sequential Proton Coupled Electron Transfer Mechanisms of Heme Protein Radical Formation: Model Studies of Human Heme Oxygenase-1."  V. V. Smirnov, J. P. Roth* in preparation.

17. "Heavy Atom Isotope Effects as Probes of Transition Metal-Mediated Small Molecule Activation." J. P. Roth* in Physical Inorganic Chemistry: Methods and Techniques Vol. 1, Wiley, New York: Accepted.

16. "Oxygen Isotope Effects as Probes of Electron Transfer Mechanisms and Structures of Activated O₂." J. P. Roth* Acc. Chem. Res. 2009, 42, 399-408.

15. "Computational Modeling of Oxygen Isotope Effects on Metal-Mediated O2 Activation at Varying Temperatures." V. V. Smirnov, M. P. Lanci, J. P. Roth* J. Phys. Chem. A. (Max Wolfsberg Festschrift), 2009, 113, 1934-1945.

14. “Evidence for Protein Radical-Mediated Nuclear Tunneling in Fatty Acid α-oxygenase.” A. Gupta, A. Mukherjee, K. Matsui, J. P. Roth* J. Am. Chem. Soc. 2008, 130, 11274-11275.

13. “The Mechanism of Molecular Oxygen Reduction Catalyzed by Copper Amine Oxidases.” A. Mukherjee, V. V. Smirnov, M. P. Lanci, D. E. Brown., E. M. Shepard, D. M. Dooley, J. P. Roth* J. Am. Chem. Soc. 2008, 130, 9459-9473.

12. “Direct Examination of H₂O₂ Activation by a Heme Peroxidase.” J. P. Roth*; C. J. Cramer* J. Am. Chem. Soc. 2008, 130, 7802-7803.

11. “Isotopic Probing of Molecular Oxygen Activation at Copper(I) Sites.” M.P. Lanci, V.V. Smirnov, C.J. Cramer, E.V. Gauchenova, J. Sundermeyer, J.P. Roth*J. Am. Chem. Soc. 2007, 129, 14697-14709.

10.“Molecular Oxygen Dependent Steps in Fatty Acid Oxidation by Cyclooxygenase-1 (COX-1)” A. Mukherjee, D. W. Brinkley, K-M. Chang, J. P. Roth* Biochemistry, 2007, 46, 3975-3989.

9.“Advances in Studying Bioinorganic Reaction Mechanisms: Isotopic Probes of Activated Oxygen Intermediates in Metalloenzymes.” J. P. Roth* Curr. Opin. Chem. Biol., 2007, 11, 142-150.

8.“Mechanisms of Electron Transfer in Catalysis by Copper Zinc Superoxide Dismutase.” V. V. Smirnov, J. P. Roth*J. Am. Chem. Soc. 2006, 128, 16424-5.

7.“Oxygen Isotope effects upon Reversible O₂-Binding Reactions: Characterizing Mononuclear Superoxide and Peroxide Structures.” M. P. Lanci, J. P. Roth* J. Am. Chem. Soc. 2006, 128, 16006-7.

6.“Probing Metal-Mediated O₂ Activation in Chemical and Biological Systems.” V. V. Smirnov, D. W. Brinkley, M. P. Lanci, K. D. Karlin, J. P. Roth* J. Molec. Catal.A 2006, 251, 100-107.

5.“Evidence for Cu-O₂Intermediates in Superoxide Oxidations by Biomimetic Copper(II) Complexes.  V. V. Smirnov, J. P. Roth* J. Am. Chem. Soc. 2006, 128, 3683-95.

4.“Oxygen Kinetic Isotope effects as Probes of Enzymatic Activation of Molecular Oxygen.” J. P. Roth*, J. P. Klinman* Isotopes Effects in Chemistry and Biology, Kohen, A. and Limbach, H.-H. Eds. CRC Press, Boca Raton 2006, pp. 645-669.

3.“Determination of a Large Reorganization Energy Barrier for Hydride Abstraction by Glucose Oxidase.” D.W. Brinkley, J.P. Roth* J. Am. Chem. Soc. 2005, 127, 15720-1.

2.“Structures of Transition States in Metal-Mediated O₂ Activation Reactions.” M.P. Lanci, D.W. Brinkley, K.L. Stone, V.V. Smirnov and J.P. Roth* Angew. Chem.Int. Ed. 2005, 44,7273-6.

1.“Oxygen Isotope Effects on Electron Transfer to O₂ Probed Using Chemically Modified Flavins Bound to Glucose Oxidase.” J. P. Roth*, R. Wincek, G. Nodet, D. E. Edmondson, W. S. McIntire and J. P. Klinman*J. Am. Chem. Soc. 2004, 126, 15120-31.