Selected Publications from the Roth Group

Reprints and preprints are available upon request-- jproth@jhu.edu .

11. “Isotopic Probing of Molecular Oxygen Activation at Copper(I) Sites.” M.P. Lanci, V.V. Smirnov, C.J. Cramer, E.V. Gauchenova, J. Sundermeyer, J.P. Roth*J. Am. Chem. Soc. 2007, 129, 14697-14709.

10.“Molecular Oxygen Dependent Steps in Fatty Acid Oxidation by Cyclooxygenase-1 (COX-1)” A. Mukherjee, D. W. Brinkley, K-M. Chang, J. P. Roth* Biochemistry, 2007, 46, 3975-3989.

9.“Advances in Studying Bioinorganic Reaction Mechanisms: Isotopic Probes of Activated Oxygen Intermediates in Metalloenzymes.” J. P. Roth* Curr. Opin. Chem. Biol., 2007, 11, 142-150.

8.“Mechanisms of Electron Transfer in Catalysis by Copper Zinc Superoxide Dismutase.” V. V. Smirnov, J. P. Roth*J. Am. Chem. Soc. 2006, 128, 16424-5.

7.“Oxygen Isotope effects upon Reversible O2-Binding Reactions: Characterizing Mononuclear Superoxide and Peroxide Structures.” M. P. Lanci, J. P. Roth* J. Am. Chem. Soc. 2006, 128, 16006-7.

6.Probing Metal-Mediated O2 Activation in Chemical and Biological Systems. V. V. Smirnov, D. W. Brinkley, M. P. Lanci, K. D. Karlin, J. P. Roth* J. Molec. Catal.A 2006, 251, 100-107.

5.“Evidence for Cu-O2Intermediates in Superoxide Oxidations by Biomimetic Copper(II) Complexes.  V. V. Smirnov, J. P. Roth* J. Am. Chem. Soc. 2006, 128, 3683-95.

4.“Oxygen Kinetic Isotope effects as Probes of Enzymatic Activation of Molecular Oxygen.” J. P. Roth*, J. P. Klinman* Isotopes Effects in Chemistry and Biology, Kohen, A. and Limbach, H.-H. Eds. CRC Press, Boca Raton 2006, pp. 645-669.

3.“Determination of a Large Reorganization Energy Barrier for Hydride Abstraction by Glucose Oxidase.” D.W. Brinkley, J.P. Roth* J. Am. Chem. Soc. 2005, 127, 15720-1.

2.“Structures of Transition States in Metal-Mediated O2 Activation Reactions.” M.P. Lanci, D.W. Brinkley, K.L. Stone, V.V. Smirnov and J.P. Roth* Angew. Chem.Int. Ed. 2005, 44,7273-6.

 

1.“Oxygen Isotope Effects on Electron Transfer to O2 Probed Using Chemically Modified Flavins Bound to Glucose Oxidase.” J. P. Roth*, R. Wincek, G. Nodet, D. E. Edmondson, W. S. McIntire and J. P. Klinman*J. Am. Chem. Soc. 2004, 126, 15120-31.