Group

The Roth Group

This picture was taken in the summer of 2006.

Left to Right: Jamal Shillingford (undergraduate researcher in the Howard Hughes fellowship program), Arnab Mukherjee (PhD student), Keng-Ming Chang (PhD student) Josh Lefkowitz (PhD student), Dr. Justine  Roth (PI), Michael Lanci (PhD student), Dr. Valeriy Smirnov (postdoctoral fellow), not pictured: Dr. David Brinkley (visiting scholar).

Read more about our research...

Dr. Valeriy SmirnovDr. Valeriy Smirnov
Post-doctoral Fellow
smirnov@jhu.edu
Curriculum Vitae (Microsoft Word Format)

My research project lies at the chemistry-biology interface. I measure oxygen-18 isotope effects on reactions of superoxide dismutases (SODs) and copper(II) model systems. Isotope effects on these reactions allow inner-sphere or the outer-sphere mechanisms of electron transfer during superoxide oxidation to be differentiated. The implications of this research are important for understanding function of SODs and design of SOD mimics.

Ankur Gupta
Graduate student
ankurg@jhu.edu

My current research interests lie in understanding the mechanisms of hydrogen transfer reactions. One goal is to use modified Marcus theory to explain enzyme catlaysis in terms of measurable quantities like reorganization energy, driving force,
and hydrogen tunneling probability.

Michael LanciMichael Lanci
Graduate student
mpl@jhu.edu

My research encompasses the study of metal-mediated electron transfer mechanisms for the activation of molecular oxygen.

 

Arnab MukherjeeArnab Mukherjee

Graduate Student

amukher6@jhu.edu

My research explores the mechanism by which the heme-containg enzyme cyclooxygenase, using a protein radical for catalytic oxygenation reactions.