Selected Research Publications

Knonkimalla, V.B.; Blunder, M; Korn, B; Jansen, H; Chang, W.; Posner, G.H.; Bauer, R. and Efferth, T. "Effect of Artemisinin and Other Endoperoxides on Nitric Oxide-Related Signalling Pathway in RAW 264.7 Mouse Macrophage Cells" in Nitric Oxide Biology and Chemistry; Eds.; John Wiley; 2008; pp . [LINK]

Hartwig, C.L.; Rosenthal, A.S.; D'Angelo, J.G.; Posner, G.H. and Cooper, R.A. "Accumulation of the Artemisinin Trioxane Derivatives Withing the Neutral Lipid Bodies of Plasmodium falciparum Malaria Parasites in Endoperoxide-Dependent" J. Biol. Chem., In preparation, , . [LINK]

Posner, G.H.; Maio, W.A. and Kalinda, A.S. "Electronically Stabilized Versions of the Antimalarial Acetal Trioxanes Artemether and Artesunate" Biorg. Med. Chem., in press, , . [LINK]

Posner, G.H. and Chang, W. "Antimalarial Sulfide Trioxanes: A Revision of Mechanism" J. Phys. Org. Chem., 2008, , . [LINK]

Posner, G.H.; Chang, W.; Hess, L.; Woodard, L.; Sinistaj, S.; Usera, A.R.; Maio, W.; Rosenthal, A.S.; Kalinda, A.S.; D'Angelo, J.G.; Petersen, K.S.; Stohler, R.; Chollet, J.; Santo-Tomas, J.; Snyder, C.; Rottmann, M.; Wittlin, S.; Brun, R. and Shapiro, T.A. "Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives" J. Med. Chem., 2008, 51, 1035-1042. [LINK]

Seydou, K.; Gillet, J.C.; Li, X.; Wang, H.; Posner, G.H.; Gregoire, G.; Schermann, J.P., Bowen, K.H. and Desfrancois, C. "Studies of Protonated and Anionic Artemisinin in the Gas-Phase by Infrared Multi-Photon Dissociation and by Negative Ion Photoelectron Spectoscopies" Chem. Phys. Letters, 2007, 449, 286-290. [LINK]

Petersen, K.S.; Dolan, P., Kensler, T.W., Peleg, S. and Posner, G.H. "Low-Calcemic, Highly Antiproliferative, 23-Oxa Ether Analogs of the Natural Hormone 1-a-25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation" J. Med. Chem., 2007, 50, 5824-5832. [LINK]

Usera, A.R.; Dolan, P.; Kensler, T.W.; and Posner, G.H. "Antiproliferative, Low-Calcemic, Fluoronated Sulfone Analogs of 1-a,25-Dihydroxyvitamin D3: Chemical Synthesis and Biological Evaluation" Bioorg. Med. Chem., 2007, 15, 5509-5518. [LINK]

Maio, W.A.; Sinishtaj, S.; and Posner, G.H. "Cyclopentanone Ring Expansion Leading to Functionalized d-Lactams: Short Synthesis of Simple Sedum Alkaloids" Org. Lett., 2007, 9, 2673-2676. [LINK]

Somjen, D.; Posner, G.H.; Weisman, Y.; and Kaye, A.M. "Less-Calcemic Vitamin D Analogs Enhance Creatine Kinase Specific Activity and Modulate Responsiveness to Gonadal Steroids in the Rat Skeletal Tissue" J. Endocrinal. Invest., 2007, 30, 91-96.

Usera, A.R. and Posner, G.H. "Unexpected Steric Effects of 'Remote' Alkyl Groups on the Rate of Conjugate Additions to Alkyl a,b-Ethylenic Sulfones, Sulfoxides and Esters" J. Org. Chem., 2007, 72, 2329-2334. [LINK]

Posner, G.H.; Paik, I.H.; Chang, W.; Borstnik, K.; Sinistaj, S.; Rosenthal, A.S.; and Shapiro, T.A. "Malaria-Infected Mice Are Cured by a Single Dose of Artemisinin Derivatives" J. Med. Chem., 2007, 50, 2516-2519. [LINK]

Lechner, D., Manhardt, T., Bajna, E., Posner, G.H., and Cross, H.S. "A 24-Sulfone Analog of Vitamin D Inhibits 1,25-Dihydrovitamin D3 Degradation in the Vitamin D Metabolism-Competent Cells" Mol. Cancer Therapeutics, In Press

Zhang, J., Posner, G.H., Danilenko, M., and Studzinski, G.P. "Differentiation-Inducing Potency of the Seco-Steroid JK-1624F2-2 Can be Increased by a Combination with an Antioxidant and a P38 Mark Inhibitor Which Upregulates the JNK Pathway" J. Steroid Biochem. Mol. Biol., 2007, 105, 140-149. [LINK]

Somjen, D., Katzburg, S., Posner, G.H., Livneh, E., and Kaye, A.M. "Systemic Treatments with Low-Calcemic 1,25(OH)2D3 Analogs JKF or QW Increase Both the Morphological and Biological Responses to Estradiol-17b in Rat Tibiae" J. Cell. Biochem., 2007, 100, 1406-1414. [LINK]

Peleg, S., Petersen, K.S., Suh, B.C., Dolan, P., Agoston, E.S., Kensler, T.W. and Posner, G.H. "Low-Calcemic, Highly Antiproliferative, 1-Difluoromethyl Hybrid Analogs of the Natural Hormone 1-a-25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluations" J. Med. Chem, 2006, 49, 7513-7517 [LINK]

Jones-Brando, L., D'Angelo, J.G., Posner, G.H., and Yolken, R. "Effective In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin" Antimicrobial Agents and Chemotherapy, 2006, 50, 4206-4209. [LINK]

Alagbala, A.A., McRiner, A.J., Borstnik, K., Labonte, T., Chang, W., D'Angelo, J.G., Posner, G.H., and Foster, B.A. "Biological Mechanisms of Action of Novel C-10 Non-Acetal Trioxane Dimers in Prostate Cancer Cell Lines" J. Med. Chem, 2006, 49, 7836-7842 [LINK]

Posner, G.H., Suh, B.C., Petersen, K.S., Dolan, P., Kensler, T.W., and Pelig, S. "Difluoromethyl Analogs of the Natural Hormone 1-a,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation" J. Steroid Biochem. Mol. Biol., 2007, 103, 213-221. [LINK]

Shinstaj, S., Jeon, H.B., Dolan, P., Kensler, T.W., and Posner, G.H. "Highly Antiproliferative, Low-Calcemic, Side-Chain Amide and Hydroxymate Analogs of the Hormone 1-a,25-Dihydroxyvitamin D3" Biorg. Med. Chem., 2006, 14, 6341-6348 [LINK]

Xu, H., McCann, M., Zhang, Z., Posner, G.H., El-Tanani, M., and Campbell, F.C. "Ligand-Activated Vitamin D Receptor Modulates the Neoplastic Phenotype Through b-Catenin/LEF-1/TCF and Osteopontin (OPN) Signaling" Oncogene, Submitted

Alagbala, A.A., Johnson, C.S., Trump, D.L., Posner, G.H., and Foster, B.A. "Mechanisms of Antitumor Effect Are Similar for Calcitriol and Two Less-Calcemic Vitamin D Analogs" Oncology, 2006, 70, 483-492.

Hatcher, M.A. and Posner, G.H. The Carroll Rearrangment. In The Claisen Rearrangement; Hiersemann, M. and Nubbemeyer, U., Eds.; John Wiley; 2006; pp 397-430. [LINK]

Sundaram, S., Beckman, M., Wei, J., Bajwa, A., Cross, S.N., Smith, K.M., Chuang, S., Korczak, B, and Posner, G.H. "A Conceptually New Synthetic Deltanoid Significantly Represses CYP 24 Expression in Human Metastatic Breast Tumor Cells in Culture" Molecular Cancer Therapeutics, 2006, 5, 2806-2814 [LINK]

Reddy, C.D., Patti, R., Guttapalli, A., Rao, J.S., Sutton, L.N., Phillips, P.C., and Posner, G.H. "Anticancer Effects of the Novel 1,a-25-Dihydroxyvitamin D3 Hybrid Analog QW-1624F2-2 in Human Neuroblastoma" J. Cell. Biochem., 2006, 97, 198-206. [LINK]

Kim, J., Li, H.B., Rosenthal, A.S., Sang, D., Shapiro, T.A., Bachi, M.D. and Posner, G.H. "Ground State Oxygen in Synthesis of Cyclic Peroxides. Part 1. Benzo Fused Ketals" Tetrahedron, 2006, 62, 4120-4127. [LINK]

Agosten, E.S., Hatcher, M., Kensler, T.W., and Posner, G.H. "Vitamin D Analogs as Anticarcinogenic Agents" Anticancer Agents in Medicinal Chemistry, 2006, 6, 53-71. [LINK]

Somjen, D., Katzburg, S., Kohen, F., Gayer, B., Sharon, O., Hendel, D., Posner, G.H. and Kaye, A. "Responsiveness to Phytoestrogens In Primary Human Osteoblasts is Modulated Differentially by a Less-Calcemic Analog of 1,25-Dihydroxyvitamin D3: JK 1624F2-2" J. Steroid Biochem. Mol. Biol., 2006, 98, 139-146. [LINK]

Paik, I-H., Xie, S., Shapiro, T.A., Labonte, T., Narducci-Sarjeant, A.A., Baege, A.C., and Posner, G.H. "Second Generation, Orally Active,Antimalarial, Artemisinin-Derived Trioxane Dimers with High Stability, Efficacy, and Anticancer Activity" J. Med. Chem., 2006, 49, 2731-2734. [LINK]

Posner, G.H., Kim, H-J., Kahraman, M., Jeon, H-B., Suh, B-C., Li, H., Dolan, P., and Kensler, T.W. "Highly Antiproliferative, Low-Calcemic Side-Chain Ketone Analogs of the Natural Hormone 1-a,25-Dihydroxyvitamin D3" Bioorg. Med. Chem., 2005, 13, 5569-5580. [LINK]

Posner, G.H., Hatcher, M., and Maio, W.M. "New Silicon-Mediated Ring Expansions of n-Sized 2-Cycloalkenones into Hydroxyolefinic n+m+p Medium-Sized Lactones: Short Synthesis of Natural (-)-Phoracantholide-J" Org. Lett., 2005, 7, 4301-4303. [LINK]

O'Neill, P.M., Rawe, S.L., Borstnik, K., Miller, A., Ward, S.A., Bray, P.G., Davies, J., Oh, C-H., and Posner, G.H. "Enantiomeric 1,2,4-Trioxanes Display Almost Identical in vitro Antimalarial Activity in Five Strains of Plasmodium falciparum Malaria Parasites: Implications for Molecular Mechanism of Action of the Artemisinins" ChemBioChem, 2005, 6, 2048-2054. [LINK]

Dixon, K.M., Deo, S.S., Wong, G., Slater, M., Norman, A.W., Bishop, J.E., Posner, G.H., Ishisuka, S., Halliday, G.M., Reeve, V.E., Mason, R.S. "Skin Cancer Prevention: A Possible Role of 1-a,25-Dihydroxyvitamin D3 and Its Analogs" J. Steroid Biochem. Mol. Biol., 2005, 97, 137-143. [LINK]

Peleg, S., Khan, F., Navarone, N.M., Cody, D.D., Johnson, E.M., Van Pelt, C.S., and Posner, G.H. "Inhibition of Prostate Cancer Bone Lesions by the Low-Calcemic Analog 1-a-hydroxymethyl-16-ene-26,27-bishomo-25-hydroxyvitamin D3" J. Steroid Biochem. Mol. Biol., 2005, 97, 203-211. [LINK]

Hatcher, M.A., Peleg, S., Dolan, P., Kensler, T.W., and Posner, G.H. "A-Ring Hydroxymethyl 19-Nor Analogs of the Natural Hormone 1-a,25-Dihydroxyvitamin D3: Synthesis and Preliminary Biological Evaluation" Bioorganic and Medicinal Chemistry, 2005, 13, 3964-3976. [LINK]

Posner, G.H., Lee, S.H.T., Kim, H.J., Peleg, S., Dolan, P., Kensler, T.W. "Novel A-Ring Analogues of the Hormone 1-a-25-dihydroxyvitamin D3: Synthesis and Preliminary Biological Activity" Bioorganic and Medicinal Chemistry, 2005, 13, 2959-2966. [LINK]

O'Neill, P.M., Rawe, S.L., Storr, R.C., Ward, S., Posner, G.H. "Lewis Acid Catalyzed Rearrangement of Unsaturated Bicyclic [2.2.n] Endoperoxides in the Presence of Vinyl Silanes: Novel Fenozan BO7 Analogues" Tetrahedron Letters, 2005, 46, 3029-3032. [LINK]

Posner, G.H., Jeon, H.B., Sarjeant, A., Riccio, E.S., Doppalapudi, R.S., Kapetanovic, I.M., Dolan, P., Kensler, T.W. Steroids, 2004, 69, 757-762. [LINK]

Kahraman, M., Sinishtaj, S., Dolan, P.M., Kensler, T.W., Peleg, S., Saha, U., Chang, S.S., Bernstein, G., Korczak, B, Posner, G.H. "Potent, Selective and Low-Calcemic Inhibitors of CYP24 Hydroxylase: 24-Sulfoxamine Analogues of the Hormone 1-a-25-dihydroxyvitamin D3" Journal of Medicinal Chemistry, 2004, 47, 6854-6863. [LINK]

Silverman SM, Suh B-Y, Posner GH, 2004 "Vitamin D Sidechain Triazole Analogs via Cycloaddtion "Click" Chemistry" Tetrahedron Letters, 2004, 45, 4623-4625. [LINK]

Posner GH, O'Neill PM, "Knowledge of the Proposed Chemical Mechanism of Action and Cytochrome P450 Metabolism of Antimalarial Trioxanes Like Artemisinin Allows Rational Design of New Antimalarial Peroxides" Accounts of Chemical Research, 2004, 37, 397-404. [LINK]

O'Neill PM, Posner GH "A Medicinal Chemistry Perspective on Artemisinin and Ralated Endoperoxides" Journal of Medicinal Chemistry, 2004, 47, 2945-2064. [LINK]

Posner GH, McRiner AJ, Paik I-P, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B, "Anticancer and Antimalarial Efficacy and Safety of Artemisinin-Derived Trioxane Dimers in Rodents" Journal of Medicinal Chemistry, 2004, 47, 1299-1301. [LINK]

Guyton KZ, Kensler TW, Posner GH, 2004 "Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs" in Cancer Chemoprevention Volume 1: Promising Cancer Chemopreventive Agents, Ch. 17, Humana Press, Totowa NJ. [LINK]

Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH, "A Short Synthesis and Biological Evaluation of Potent and Nontoxic Antimalarial Bridged Bicyclic beta-Sulfonyl Endoperoxides" Journal of Medicinal Chemistry, 2003, 46, 2516-1533. [LINK]

Posner GH, Kahraman M, "Organic Chemistry of Vitamin D Analogues (Deltanoids)" European Journal of Organic Chemistry, 2003, 20, 3889-3895. [LINK]

Hatcher M, Borstnik K, Posner GH "New silicon mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones," Tetrahedron Letters, 2003, 44, 5407-5409. [LINK]

Peleg S, Posner GH, "Vitamin D Analogs as Modulators of Vitamin D Receptor Action," Current Topics in Medicinal Chemistry, 2003, 3, 1555-1572.

Posner GH, Maxwell JP, Kahraman M, "Mild, Fast, and Stereoselective Epoxide Opening by Ketone Enloate Ions: Application to Synthesis of the Norlignan Curculigine," Journal of Organic Chemistry, 2003, 68, 3049-3054.

Posner GH, Paik, IP, Sur S, Xie S, Borstnik K, Shapiro TA, "Orally Active Antimalarial, Anticancer, Artemisini-Derived, Trioxane Dimers with High Stability and Efficacy," Journal of Medicinal Chemistry, 2002, 46, 1060-1065.

Hatcher M, Posner GH "[3,3]-Sigmatropic Rearrangements: Short, Stereocontrolled Syntheses of Functionalized Vitamin D Side Chain Units," Tetrahedron Letters, 2002, 43, 5009-5012.

Posner GH Jeon HB, Ploypradith P, Paik IP, Borstnik, K, Xie S, Shapiro TA, "Orally Active, Water Soluble, Antimalarial 3-Aryltrioxanes: Short Synthesis and Preclinical Efficacy Testing in Rodents," Journal of Medicinal Chemistry, 2002, 45, 3824-3828.

Carreno, MC, Ribagorda, M, Posner, GH "Titanium-Promoted Stereoselective Synthesis of Hydroindolones from p-Quinamines by Domino Conjugate Additions," Angewandte Chemie, 2002, 41, 2753-2754.

Korshin, EE, Hoos R, Szpilman AM, Konstantinovski L, Posner GH, Bachi MD "An Efficient Synthesis of Bridged Bicyclic Peroxides Structurally Related to Antimalarial Yingzhaosu A Based on Radical Co-oxygenation of Thiols and Monoterpenes," Tetrahedron, 2002, 58, 2449-2469.

Posner GH, Halford H, Peleg S, Dolan P, Kensler TW "Conceptually New Low-calcemic Oxime Analogs of the Hormone 1-a,25-Dihydroxyvitamin D3: Synthesis and Biological Testing." Journal of Medicinal Chemistry, 2002, 45, 1723-1730.

Posner GH, Woodard BT, Crawford KR, Peleg S, Dolan P, Kensler TW, "2,2-Disubstitituted Analogs of the Hormone 1a,25-Dihydroxyvitamin D3: Synthesis and Biological Evaluation." Bioorganic and Medicinal Chemistry, 2002, 10, 2353-2365.

Borstnik K, Paik I-H, Posner GH, "Malaria: New Chemotherapeutic Peroxide Drugs." MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2002, 2, 573-583.

Posner GH, Northrop J, Pail I-K, Bortsnik K, Dolan P, Kensler TW, Xie S, Shapiro TA, "New Chemical and Biological Aspects of Artemisinin-Derived Trioxane Dimers, Bioorganic and Medicinal Chemistry, 2002, 10, 227-232.

Somjen D, Waisman A, Lee JK, Posner GH, Kaye AM. "A Noncalcemic Analog of 1,25-Dihydroxyvitamin D3 (JKF) Upregulates The Induction of Creatine Kinase B by 17-beta Estradiol in Osteoblast-like ROS 17/2.8 Cells and in Rat Diaphysis." Journal of Steroid Biochemistry and Molecular Biology, 2001, 77, 205-212.

Szpilman AM, Korshin EE, Hoos R, Posner GH, Bachi MD, "Iron(II)-Induced Cleavage of Antimalarial Beta-Sulfonyl Endoperoxides. Evidence for the Generation of Potentially Cytotoxic Carbocations," Journal of Organic Chemistry, 2001, 66, 6531-6540.

Posner GH, Jeon HB, Parker MH, Krasavin M, Paik I-K, Shapiro TA, "Antimalarial Simplified 3-Aryltrioxanes: Synthesis and Preclinical Efficacy/Toxicity Testing in Rodents," Journal of Medicinal Chemistry, 2001, 44, 3054-3058.

Gardezi SA, Nguyen C, Malloy PJ, Feldman D, Posner GH, Peleg S, "A Rationale for Treatment of Hereditary Vitamin D Resistant Rickets with Analogs of 1-a-25-Dihydroxyvitamin D3," Journal of Biological Chemistry. 2001, 276, 29148-29156.

Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW, "A Non-Calcemic Sulfone Version of The Vitamin D3 Analog Seocalcitol (EB 1089): Chemical Synthesis, Biological Evaluation, and Potency Enhancement of the Anticancer Drug Adriamycin," Bioorganic and Medicinal Chemistry, 2001, 9, 2365-2371.

O'Neill P M, Miller A, Bishop L P D, Hindley S, Maggs J L, Ward S A, Roberts S M, Scheinman F, Hoos R, Posner G H, Park B K, "Synthesis, Antimalarial Activity, Biomimetic Iron(II) Chemistry, and the in vitro Metabolism of Novel, Potent C-10-Phenoxy Derivatives of Dihydroartemisinin," Journal of Medicinal Chemistry, 2001, 44, 58-68.

Posner G H, Krasavin M, McCutchen M, Ploypradith P, Maxwell J P, Elias J S, Patker M H, "New Antimalarial Trioxanes and Endoperoxides," Antimalarial Chemotherapy, 2001, 255-263.

Weiskopf A S, Vouros P, Cuniff J, Binderup E, Bjorkling F, Binderup L, White M C, Posner G H, "Examination of Structurally-Selective Derivatization of Vitamin D3 Analogues by Electrospray Mass Spectrometry," Journal of Mass Spectrometry, 2001, 36, 71-78.

Guyton K Z, Kensler T W, Posner G H, "Cancer Chemoprotection Using Natural Vitamin D3 and Synthetic Analogs," Annual Review of Pharmacology and Toxicology, 2001, 41, 421-442.

Posner G H, Crawford K R, Peleg S, Welsh J-E, Romu S, Gewirtz D A, Gupta M S, Dolan P, Kensler T W, "A Non-Calcemic Sulfone Version of the Vitamin D3 Analog Seocalcitol (EB 1089): Chemical Synthesis, Biological Evaluation, and Potency Enhancement of the Anticancer Drug Adriamycin," Bioorganic and Medicinal Chemistry. 2001, 9, 2365-2371.

Posner G.H., Crawford K., Siu-Caldera M.L., Reddy G.S., Sarabia S., Feldman D., van Etten E., Mathieu C., Gennaro L., Vouros P., Peleg S., Dolan P., Kensler T.W. "Conceptually New 20-Epi-22-oxa-sulfone Analogs of the Hormone 1a,25-Dihydroxyvitamin D3: Synthesis and Preliminary Biological Evaluation." Journal of Medicinal Chemistry. 2000, 43, 3581-3586.

Somjen D., Waisman A., Lee J.K., Posner G.H., and Kaye A.M. "New Noncalcemic Analogs of 1a,25-Dihydroxyvitamin D3 Upregulate the Induction of Creatine Kinase C by Estogen and Selective Estrogen Receptor Modulators (SERMS) in Osteoblast-like ROS 17/2.8 Cells and in Rat Diaphysis." JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY.

Posner G.H., Maxwell J.P., O'Dowd H., Krasavin M., Xie S., and Shapiro T.A. "Antimalarial Sulfide, Sulfone, and Sulfonamide Trioxanes." Bioorganic Medicinal Chemistry. 2000, 8, 1361-1370.

Kensler T.W., Gange S., Dolan P. M., Lee J.K., Wang Q., and Posner G.H. "Conceptually New Deltanoids (Vitamin D Analogs) Inhibit Multistage Skin Carcinogenesis." Carcinogenesis. 2000, 21, 1341-1346.

Posner G. H., Krasavin M., McCutchen M., Ploypradith P., Maxwell J.P., Elias J.S., and Parker M.H. "New Antimalarial Trioxanes and Endoperoxides." INVITED REVIEW CHAPTER IN THE BOOK "Antimalarial Chemotherapy". 2000, P. Rosenthal, Ed,, John Wiley.

Posner G. H., Cumming J. N., and Krasavin M. "Carbon-Centered Radicals and Rational Design of New Antimalarial Peroxide Drugs." INVITED REVIEW CHAPTER IN THE BOOK "BIOMEDICAL CHEMISTRY: APPLYING CHEMICAL PRINCIPLES TO THE UNDERSTANDING AND TREATMENT OF DISEASE. 2000, P. Torrence, Ed,, John Wiley. 289-309.

O'Neill P M, Miller A, Bickley J F, Scheinman F, Stachulski A V, Oh C H, Posner G H. "Asymmetric syntheses of enantiomeric 3-p-flurorophenyl 1,2,4-trioxane analogs of the antimalarial artemisinin." Tetrahedron Letters. 1999, 40, 9133-9136.

Posner G H, Ploypradith P, Parker M H, O'Dowd H, Woo,S-H, Northrop J, Krasavin M, Dolan P, Kensler T W, Xie S, Shapiro T A. "Antimalarial, antiproliferative, and antitumor activities of artemisinmin-derived, chemically robust, trioxane dimers." Journal of Medicinal Chemistry. 1999, 42, 4275-4280.

Posner G H, Parker M H, Northrop J, Elias J S, Ploypradith P, Xie S, Shapiro T A. "Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family." Journal of Medicinal Chemistry. 1999, 42, 300-304.

O'Dowd H, Ploypradith P, Xie S, Shapiro T A., Posner G H. "Antimalarial Artemisinin Analogs: Synthesis via Chemoselective C-C Bond Formation and Preliminary Biological Evaluation." Tetrahedron. 1999, 55, 3625-3636.

Woodard BT, Posner G H. "Recent Advances in Diels-Alder Cycloadditions Using 2-Pyrones." Advances in Cycloaddition. 1999, 5, 47-83.

Boyan, B.D., Sylvia, V.L., Dean, D.D., Pedrozo, H., Del Toro, , Nemere, I, Posner, G.H., Schwartz, Z. "1,250(OH)2D3 NModulates Growth Plate Chondrocytes via Membrane Receptor-mediated Protein Kinase C by a Mechanism that Involves Changes in Phospholipid Metabolism and the Action of Arachidonic Acid and PGE2." Steroids. 1999, 64, 129-136.

Hofer H, Ho G, Petrlik M, Uskokovic M R, Lee J K, White M C, Posner G H, Cross H S. "Biological Effects of 1-a-Hydroxymethyl- and 1-beta-Hydroxymethyl Vitamin D Compounds Relevant for Potential Colorectal Cancer Therapy." Journal of Pharmacology and Experimental Therapeutics. 1999, 291, 450-455.

Pedrozo, H.A., Schwartz, Z., Rimes, S., Sylvia. V.L., Nemere, I., Posner, G.H., Dean, D.D., Boyan, B.D. "Physiological Importance of the 1,25(OH)2D3 Membrane Receptor and Evidence for a Membrane Receptor Specific for 24,25(OH)2D3." Journal of Bone and Mineral Research. 1999, 14, 856-867.

Posner G H, Wang Q, Han G., Lee J K, Crawford K, Zand S, Brem H. Peleg S, Dolan P, Kensler T W. "Conceptually New Sulfone Analogs of the Hormone 1,25-Dihydroxyvitamin D3: Synthesis and Preliminary Biological Evaluation." Journal of Medicinal Chemistry. 1999, 42, 3425-3435.

Posner G H, Cumming J N, Woo S H, Ploypradith P, Xie S, Shapiro T A. "Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation." Journal of Medicinal Chemistry. 1998, 41, 940-951.

Cumming J N, Wang D, Park S B, Shapiro T A, Posner G H. "Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin." Journal of Medicinal Chemistry. 1998, 41, 952-964.

Posner G H, Lee J K, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler T W. "Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1a, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation." Journal of Medicinal Chemistry. 1998, 41, 3008-3014.

Bachi M D, Korshin E E, Ploypradith P, Cumming J N, Xie S, Shapiro T A, Posner G H. "Synthesis and in vitro antimalarial activity of sulfone endoperoxides." Bioorganic and Medicinal Chemistry 1998, 8, 903-908.

Posner G H, O'Dowd H, Ploypradith P, Cumming J N, Xie S, Shapiro T A. "Antimalarial cyclic peroxy ketals." Journal of Medicinal Chemistry. 1998, 41, 2164-2167.

Peleg S, Nguyen C, Woodard B T, Lee J K, Posner G H. "Differential use of transcription activation function 2 domain of the vitamin D receptor by 1,25-dihydroxyvitamin D3 and its A ring-modified analogs." Molecular Endocrinology. 1998, 12, 525-535.

Posner G H, Ploypradith P, Hapangama W, Wang D, Cumming J N, Dolan P, Kensler T W, Klinedinst D, Shapiro T A, Zheng Q Y, Murray C K, Pilkington L G, Jayasinghe L R, Bray J F, Daughenbaugh R. "Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro." Bioorganic and Medicinal Chemistry. 1997, 5, 1257-1265.

Posner, G.H. "Antimalarial Endoperoxides That are Potent and Easily Synthesized." Journal of Pharmacy and Pharmacology. 1997, 49, 55-57.

Cumming J N, Ploypradith P, Posner G H. "Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action." Advances in Pharmacology. 1997, 37, 253-297.

Boyan B D, Posner G H, Greising D M, White M C, Sylvia V L, Dean D D, Schwartz Z. "Hybrid structural analogues of 1,25-(OH)2D3 regulate chondrocyte proliferation and proteoglycan production as well as protein kinase C through a nongenomic pathway." Journal of Cellular Biochemistry. 1997, 66, 457-470.

Greising D M, Schwartz Z, Posner G H, Sylvia V L, Dean D D, Boyan B D. "A-ring analogues of 1, 25-(OH)2D3 with low affinity for the vitamin D receptor modulate chondrocytes via membrane effects that are dependent on cell maturation." Journal of Cellular Physiology. 1997, 171, 357-367.

Posner, G.H., Tao, X., Cumming, J.N., Klinedinst, D., Shapiro, T.A.. "Antimalarially Potent, Simple, Easily Prepared, Fluorinated Endoperoxides." Tetrahedron Letters. 1996, 37, 7225-7228.

Meshnick, S., Jefford, C.W., Posner, G.H., Avery, M.A., Peters, W. "Second Generation Antimalarial Endoperoxides." Parasitology Today. 1996, 12, 79-82.

Posner, G.H., Bull, D.S. "Molecular Sieves Promote Stereocontrolled a,a-Disaccharide Formation via Direct Dimerization of Free Sugars." Tetrahedron Letters. 1996, 37, 6279-6282.

Posner, G.H., Dai, H., Bull, D.S., Lee. J.K., Eydoux, F., Ishihara, Y., Welsh, W., Pryor, N., Petr, S. "Lewis Acid-Promoted, Stereocontrolled, Gram Scale Diels-Alder Cycloadditions of Electronically Matched 2-Pyrones and Vinyl Ethers: The Critical Importance of Molecular Sieves and Temperature of Complexation with the Pyrone." Journal of Organic Chemistry. 1996, 61, 671-676.

Posner, G.H., Park, S.B., Gonzalez, L., Wand, D., Cumming, J.N., Klinedinst, D., Shapiro, T.A., Bachi, M.D. "Evidence for the Importance of a High-Valent Fe=O and of a Diketone in the Molecular Mechanism of Action of Antimalarial Trioxane Analogs of Artemisinin. Journal of the American Chemical Society. 1996, 118, 3537-3538.