Selected Research Publications

Moon, D.K.; Tripathi, A.; Sullivan, A.; Siegler, M. A.; Parkin, S.; Posner, G. H. "A Single, Low, Oral Dose of a 5-Carbon-linked Trioxane Dimer Orthoester Plus Mefloquine Cures Malaria-infected Mice" Bioorg. Med. Chem. Lett., 2011, Special Issue on "Recent Advances in Medicinal Chemistry," in press. [LINK]

Xu, H.; Posner, G. H.; Stevenson, M.; Campbell, F. C. "ApcMIN Moldulation of Vitamin D Secosteroid Growth Control" Carcinogenesis" Carcinogenesis, 2010, 31, 1434-1441. [LINK]

Genna, D. T.; Hencken, C. P.; Siegler, M. A.; Posner, G. H. "Alpha-Chloro-beta,gamma-ethylenic Esters: Enantiocontrolled Synthesis and Substitutions" Org. Lett., 2010, 12 (20), 4694-4697. [LINK]

Hess, L. C.; Posner, G. H. "Asymmetric, Organocatalytic, Three-Step Synthesis of alpha-Hydroxy-(E)-beta,gamma-unsaturated Esters" Org. Lett., 2010, 12 (9), 2120, 2122. [LINK]

Hencken, C. P.; Brando-Jones, L.; Bordon, C.; Stohler, R.; Mott, B. T.; Yolken, R.;Posner, G. H., Woodard, L. E. "Thiazole, Oxadiazole, and Carboxamide Derivativesof Artemisinin are Highly Selective and Potent Inhibitors of Toxoplasma gondii" J. Med. Chem., 2010, 53, 3594-3601. [LINK]

Boyer, R.; Chiou, C. J.; Liu, J. Y.; Woodard, L. E.; Rosenthal, A. S.; Brando-Jones, L.; Posner, G. H. "Artemisinin-Derived Dimers have Greatly Improved Anti-Cytomegalovirus Activity Compared to Artemisinin Monomers" PloS ONE, 2010, 5 (4), e10370. [LINK]

Somjen, D.; Katzburg, S.; Knoll, E.; Sharon, O.; Posner, G. H.; Stern, N. "Vitamin D Analogs Induce Lipoxygenase mRNA Expression and Activity as well as Reactive Oxygen Species (ROS) Production in Human Bone Cells" J. Steroid Biochem Mol. Biol., 2010, 121, 265-267. [LINK]

Posner, G. H.; Helvig, C.; Cuerrier, D.; Collop, D.; Karebov, A.; Ryder, K. .; Petkovich, M. "Vitamin D Analogs Targeting CYP24 in Chronic Kidney Disease" J. Steroid Biochem Mol. Biol., 2010, 121, 13-19. [LINK]

Moon, D.K.; Singhal, V.; Kumar, N.; Shapiro, T.A. and Posner, G.H. “Antimalarial Preclinical Drug Development: A Single Dose of a 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-infected Mice” Drug Development Research, 2009, Special Issue on Malaria – invited submission, 71, 76-81. [LINK]

Woodard, L.E.; Chang, W.; Chen, X.; Liu, J.O.; Shapiro, T.A. and Posner, G.H. “Malaria-Infected Mice Live Until at least Day 30 After a New Monomeric Trioxane Combined with Mefloquine are Adminstered Together as a Single Low Oral Dose” J. Med. Chem., 2009, 52, 7458–7462. [LINK]

Usera, A.R.; Dolan, P.; Kensler, T.W. and Posner, G.H. “Novel Alkyl Side Chain Sulfones of 1a,25-dihydroxyvitamin D3 Analogs: A Comparison of in vitro Antiproliferative Activities and in vivo Calcemic Activities” Bioorg. Med. Chem., 2009, 17, 5627-5631. [LINK]

Somjen, D.; Mirsky, N.; Tamir, A.; Vaya, J.; Posner, G.H. and Kaye, A.M. “The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-calcemic Analogs” Int. J. Cell. Bio., 2009, in press. [LINK]

Xu, H.; McCann, M.; Zhang, Z.; Posner, G.H.; Bingham, V.; El-Tanani, M. and Campbell, F.C. “Vitamin D Receptor (VDR) Modulates the Neoplastic Phenotype Through Antagonistic Growth Regulatory Signals” Mol. Carcinogen., 2009, 48, 758-772. [LINK]

Rosenthal, A.S.; Chen, X.; Liu, J.O.; West, D.C.; Hergenrother, P.J.; Shapiro, T.A. and Posner, G.H. "Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells" J. Med. Chem., 2009, 52, 1198-1203. [LINK]

Jeon, H.B. and Posner, G.H. "New A-ring analogs of the hormone 1a,25-dihydroxyvitamin D3: (2'-hydroxymethyl)tetrahydrofuro[1,2-a]-25-hydroxyvitamin D3" Tetrahedron, 2009, 65, 1235-1240. [LINK]

Hartwig, C.L.; Rosenthal, A.S.; D'Angelo, J.G.; Posner, G.H. and Cooper, R.A. "Accumulation of the Artemisinin Trioxane Derivatives Within the Neutral Lipid Bodies of Plasmodium falciparum Malaria Parasites in Endoperoxide-Dependent" Biochemical Pharmacology, 2009, 77, 322-336. [LINK]

D'Angelo, J.; Bordon, C.; Posner, G.H.; Yolken, R. and Jones-Brando, L. "Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle" J. Antimicrob. Chemoth., 2009, 63, 146-150. [LINK]

Petersen, K.S. and Posner, G.H. "Asymmetric, organocatalytic, three-step synthesis of gamma-hydroxy-(E)-alpha,beta-unsaturated sulfones and esters." Org. Lett., 2008, 10, 4685-4687. [LINK]

Knonkimalla, V.B.; Blunder, M; Korn, B; Jansen, H; Chang, W.; Posner, G.H.; Bauer, R. and Efferth, T. "Effect of Artemisinin and Other Endoperoxides on Nitric Oxide-Related Signalling Pathway in RAW 264.7 Mouse Macrophage Cells" in Nitric Oxide Biology and Chemistry; Eds.; John Wiley; 2008, 19, 184-191. [LINK]

Posner, G.H.; Maio, W.A. and Kalinda, A.S. "Electronically Stabilized Versions of the Antimalarial Acetal Trioxanes Artemether and Artesunate" Biorg. Med. Chem., 2008, 16, 5247-5253. [LINK]

Posner, G.H. and Chang, W. "Antimalarial Sulfide Trioxanes: A Revision of Mechanism" J. Phys. Org. Chem., 2008, 21, 538-540. [LINK]

Posner, G.H.; Chang, W.; Hess, L.; Woodard, L.; Sinistaj, S.; Usera, A.R.; Maio, W.; Rosenthal, A.S.; Kalinda, A.S.; D'Angelo, J.G.; Petersen, K.S.; Stohler, R.; Chollet, J.; Santo-Tomas, J.; Snyder, C.; Rottmann, M.; Wittlin, S.; Brun, R. and Shapiro, T.A. "Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives" J. Med. Chem., 2008, 51, 1035-1042. [LINK]