publications

VOLUMES EDITED:
"Copper Coordination Chemistry: Biochemical and Inorganic Perspectives" Karlin, K. D.; Zubieta, J., Eds.; Adenine Press: Guilderland, N.Y., 1983. "Biological & Inorganic Copper Chemistry" Karlin, K. D.; Zubieta, J., Eds.; Adenine Press: Guilderland, N.Y., 1986; Vol. 1-2. "Bioinorganic Chemistry of Copper" Karlin, K. D., Tyeklár, Z., Eds., Chapman & Hall: New York, 1993. Progress in Inorganic Chemistry, Karlin, K. D., Editor, John Wiley & Sons: New York, N.Y.. Volume 41, 1994 (9 chapters, 848 pp); Volume 42, 1995 (5 chapters, 606 pp) Volume 43, 1996 (6 chapters, 621 pp); Volume 44, 1996 (7 chapters, 421 pp) Volume 45, 1997 (6 chapters, 510 pp); Volume 46, 1997 (4 chapters, 488 pp) Volume 47, 1998 (8 chapters, 978 pp); Volume 48, 1999 (6 chapters, 603 pp) Volume 49, 2001 (6 chapters, 700 pp); Volume 50, 2001 (8 chapters, 631 pp) Volume 51, 2003 (5 chapters, 640 pp); Volume 52, 2004 (11 chapters, 738 pp) Volume 53, 2005 (2 chapters, 602 pp); Volume 54, 2005, (7 chapters, 535 pp)
PUBLICATIONS :
255. Maiti, D.; Lee, D. H.; Gaoutchenova, K.; Wurtele, C.; Holthausen, M. C.; Sarjeant, A. A. N.; Sundermeyer, J.; Schindler, S.; Karlin, K. D., Copper superoxo complexes - Reactions of a copper(II) superoxo complex lead to C-H and O-H substrate oxygenation: Modeling copper-monooxygenase C-H hydroxylation. Angewandte Chemie-International Edition 2008, 47, 82-85. 254. Lee, Y.; Lee, D. H.; Sarjeant, A. A. N.; Karlin, K. D., Thiol-copper(I) and disulfide-dicopper(I) complex O-2-reactivity leading to sulfonate-copper(II) complex or the formation of a cross-linked thioether-phenol product with phenol addition. Journal of Inorganic Biochemistry 2007, 101, 1845-1858. 253. Maiti, D.; Woertink, J. S.; Vance, M. A.; Milligan, A. E.; Sarjeant, A. A. N.; Solomon, E. I.; Karlin, K. D., Copper(I)/S-8 reversible reactions leading to an end-on bound dicopper(II) disulfide complex: Nucleophilic reactivity and analogies to copper-dioxygen chemistry. Journal of the American Chemical Society 2007, 129, 8882-8892. 252. Chufan, E. E.; Mondal, B.; Gandhi, T.; Kim, E.; Rubie, N. D.; Moenne-Loccoz, P.; Karlin, K. D., Reactivity studies on Fe-III-(O-2(2-))-Cu-II compounds: Influence of the ligand architecture and copper ligand denticity. Inorganic Chemistry 2007, 46, 6382-6394. 251. Lee, D. H.; Hatcher, L. Y. Q.; Vance, M. A.; Sarangi, R.; Milligan, A. E.; Sarjeant, A. A. N.; Incarvito, C. D.; Rheingold, A. L.; Hodgson, K. O.; Hedman, B.; Solomon, E. I.; Karlin, K. D., Copper(I) complex O-2-reactivity with a N3S thioether ligand: A copper-dioxygen adduct including sulfur ligation, ligand oxygenation, and comparisons with all nitrogen ligand analogues. Inorganic Chemistry 2007, 46, 6056-6068. 250. Chufan, E. E.; Puiu, S. C.; Karlin, K. D., Heme-copper/dioxygen adduct formation, properties, and reactivity. Accounts of Chemical Research 2007, 40, 563-572. 249. Maiti, D.; Lucas, H. R.; Sarjeant, A. A. N.; Karlin, K. D., Aryl hydroxylation from a mononuclear copper-hydroperoxo species. Journal of the American Chemical Society 2007, 129, 6998-. 248. Maiti, D.; Sarjeant, A. A. N.; Karlin, K. D., Copper(II) - Hydroperoxo complex induced oxidative n-dealkylation chemistry. Journal of the American Chemical Society 2007, 129, 6720-. 247. Lee, D. H.; Murthy, N. N.; Karlin, K. D., Copper-dioxygen reactivity using dinucleating ligands with activated methylene or ketone function. Bulletin of the Chemical Society of Japan 2007, 80, 732-742. 246. Ghiladi, R. A.; Chufan, E. E.; del Rio, D.; Solomon, E. I.; Krebs, C.; Huynh, B. H.; Huang, H. W.; Moenne-Loccoz, P.; Kaderli, S.; Honecker, M.; Zuberbuhler, A. D.; Marzilli, L.; Cotter, R. J.; Karlin, K. D., Further insights into the spectroscopic properties, electronic structure, and kinetics of formation of the heme-peroxo-copper complex [(F8TPP)Fe-III-(O-2(2-))-Cu-II(TMPA)](+). Inorganic Chemistry 2007, 46, 3889-3902. 245. Himes, R. A.; Park, G. Y.; Barry, A. N.; Blackburn, N. J.; Karlin, K. D., Synthesis and X-ray absorption spectroscopy structural studies of Cu(I) complexes of HistidylHistidine peptides: The predominance of linear 2-coordinate geometry. Journal of the American Chemical Society 2007, 129, 5352-. 244. Chufan, E. E.; Verani, C. N.; Puiu, S. C.; Rentschler, E.; Schatzschneider, U.; Incarvito, C.; Rheingold, A. L.; Karlin, K. D., Generation and characterization of [(P)M-(X)-Co(TMPA)](n+) assemblies; P = porphyrinate, M = Fe-III and Co-III, X = O2-, OH-, O-2(2-), and TMPA = tris(2-pyridylmethyl)amine. Inorganic Chemistry 2007, 46, 3017-3026. 243. Maiti, D.; Fry, H. C.; Woertink, J. S.; Vance, M. A.; Solomon, E. I.; Karlin, K. D., A 1 : 1 copper-dioxygen adduct is an end-on bound superoxo copper(II) complex which undergoes oxygenation reactions with phenols. Journal of the American Chemical Society 2007, 129, 264-265. 242. Hatcher, L. Q.; Lee, D. H.; Vance, M. A.; Milligan, A. E.; Sarangi, R.; Hodgson, K. O.; Hedman, B.; Solomon, E. I.; Karlin, K. D., Dioxygen reactivity of a copper(I) complex with a N3S thioether chelate; Peroxo-dicopper(II) formation including sulfur-ligation. Inorganic Chemistry 2006, 45, 10055-10057. 241. Lee, Y.; Lee, D. H.; Sarjeant, A. A. N.; Zakharov, L. N.; Rheingold, A. L.; Karlin, K. D., Thioether sulfur oxygenation from O-2 or H2O2 reactivity of copper complexes with tridentate N2Sthioether ligands. Inorganic Chemistry 2006, 45, 10098-10107. 240. Li, L.; Murthy, N. N.; Telser, J.; Zakharov, L. N.; Yap, G. P. A.; Rheingold, A. L.; Karlin, K. D.; Rokita, S. E., Targeted guanine oxidation by a dinuclear copper(II) complex at single stranded/double stranded DNA junctions. Inorganic Chemistry 2006, 45, 7144-7159. 239. Li, L.; Sarjeant, A. A. N.; Karlin, K. D., Reactivity study of a hydroperoxodicopper(II) complex: Hydroxylation, dehydrogenation, and ligand cross-link reactions. Inorganic Chemistry 2006, 45, 7160-7172. 238. Thyagarajan, S.; Murthy, N. N.; Sarjeant, A. A. N.; Karlin, K. D.; Rokita, S. E., Selective DNA strand scission with binuclear copper complexes: Implications for an active Cu-2-O-2 species. Journal of the American Chemical Society 2006, 128, 7003-7008. 237. Sprakel, V. S. I.; Elemans, J.; Feiters, M. C.; Lucchese, B.; Karlin, K. D.; Nolte, R. J. M., Synthesis and characterization of PY2- and TPA-appended diphenylglycoluril receptors and their bis-Cu-I complexes. European Journal of Organic Chemistry 2006, 2281-2295. 236. Smirnov, V. V.; Brinkley, D. W.; Lanci, M. P.; Karlin, K. D.; Roth, J. P., Probing metal-mediated O-2 activation in chemical and biological systems. Journal of Molecular Catalysis a-Chemical 2006, 251, 100-107. 235. Hatcher, L. Q.; Vance, M. A.; Sarjeant, A. A. N.; Solomon, E. I.; Karlin, K. D., Copper-dioxygen adducts and the side-on peroxo dicopper(II)/bis(mu-oxo) dicopper(III) equilibrium: Significant ligand electronic effects. Inorganic Chemistry 2006, 45, 3004-3013.. 234. Hatcher, L. Q.; Karlin, K. D., Ligand influences in copper-dioxygen complex-formation and substrate oxidations. In Advances in Inorganic Chemistry Including Bioinorganic Studies, Vol 58, 2006; pp 131-184. 233. Lee, Y.; Sarjeant, A. A. N.; Karlin, K. D., A molecular pinwheel multicopper(I) cluster, [LS-)(6)Cu-13(I)(S2-)(2)](3+) with mu(4)-sulfido, mu(3)-thiolato and nitrogen ligands. Chemical Communications 2006, (6), 621-623. 232. Helton, M. E.; Maiti, D.; Zakharov, L. N.; Rheingold, A. L.; Porco, J. A.; Karlin, K. D., A mu-eta(2):eta(2)-disulfide dicopper(II) complex from reaction of S-8 with a copper(I) precursor: Reactivity of the bound disulfur moiety. Angewandte Chemie-International Edition 2006, 45, 1138-1141. 231. Li, Lei; Narducii, Sarjeant, Amy A.; Vance, Michael A.; Zakharov, Lev N.; Rheingold, Arnold, L.; Solomon, Edward I.; Karlin, Kenneth D., "Exogenous Nitrile Substrate Hydroxylation by a New Dicopper Hydroperoxide Complex" J. Am. Chem. Soc., 2005, 127, 15360-15361. {Highlighted in the Science magazine section on "Highlights of Recent Literature, Editor's Choice", Science, 2005, 310, 591}. 230. Shearer, J.; Karlin, K. D. "Copper: Hemocyanin/Tyrosinase Models" In Encyclopedia of Inorganic Chemistry, 2nd Ed., Vol. II, King, R. B., Editor, Wiley:Chichester, 2005; pp 1091-1100. 229. Sprakel, Vera S. I.; Feiters, Martin C.; Meyer-Klaucke, Wolfram, Klopstra, Marten, Brinksma, Jelle, Feringa, Ben L.; Karlin, Kenneth D.; Nolte, Roeland J. M. "Oxygen Binding and Activation by the Complexes of PY2- and TPA- appended Diphenylglycoluril Receptors with Copper and Other Metals", Dalton Trans. 2005, 3522-3534. 228. Ito, Takeo; Thyagarajan, Sunita; Karlin, Kenneth D.; Rokita, Steve E. "Recognition of Guanines at a Double Helix-Coil Junction in DNA by a Trinuclear Copper Complex", Chem. Comm., 2005, 4812-4814. 227. Kim, Eunsuk; Helton, Matthew E.; Lu, Shen; Moënne-Loccoz, Pierre; Incarvito, Christopher D.; Rheingold, Arnold L.; Kaderli, Susan; Zuberbühler, Andreas D.; Karlin, Kenneth D., "Tridentate Copper Ligand Influences on Heme-Peroxo-Copper Formation and Properties: Reduced, Superoxo, and μ-Peroxo Fe/Cu Complexes", Inorg. Chem., 2005, 44, 7014-7029. 226. del Río, Diego; Sarangi, Ritimunkta, Chufán, Eduardo, Karlin, Kenneth D.; Hedman, Britt; Hodgson, Keith O.; Solomon, Edward I. "Geometric and Electronic Structure of the Heme-Peroxo-Copper Complex [(F₈TPP)Fe^III-(O₂^2-)-Cu^II(TMPA)](ClO₄)" J. Am. Chem. Soc., 2005, 127, 11969-11978. 225. H. Christopher, Fry, Andrew. D. Cohen, John P. Toscano, Gerald J. Meyer and Kenneth D. Karlin, "Photoinduced Carbon Monoxide Migration in a Synthetic Heme-Copper Complex" J. Am. Chem. Soc., 2005, 127, 6225-6230. 224. Shearer, J; Zhang, C. X.; Zakharov, L. M.; Rheingold, A. L.; Karlin, K. D. "Substrate Oxidations by Copper-Dioxygen Adducts: Mechanistic Considerations" J. Am. Chem. Soc., 2005, 127, 5469-5483. 223. Wasser, I. M.; Huang, H.-w.; Moënne-Loccoz, P.; Karlin, K. D. "Heme/Non-Heme Diiron(II) Complexes and O₂, CO and NO Adducts as Reduced and Substrate Bound Models for the Active Site of Bacterial Nitric Oxide Reductase (NOR)", J. Am. Chem. Soc., 2005, 127, 3310-3320. 222. Kim, E.; Kamaraj, K.; Galliker, B.; Rubie, N. D.; Moënne-Loccoz, P.; Kaderli, S.; Zuberbühler, A. D.; Karlin, K. D. "Dioxygen Reactivity of Copper and Heme-Copper Complexes Possessing an Imidazole-Phenol Cross-Link", Inorg. Chem., 2005, 44, 1238-1247. 221. Osako, T.; Karlin, K. D.; Itoh, S. "Carbon-Halogen Bond Activation Mechanism by Copper Complexes of (2-Pyridyl)alkylamine Ligands", Inorg. Chem., 2005, 44, 410-415. 220. Li, Lei; Karlin, Kenneth D.; Rokita, Steven E. “Changing Selectivity of DNA Oxidation from Deoxyribose to Guanine by Ligand Design and a New Binuclear Copper Complexe" J. Am. Chem. Soc., 2005, 127, 520-521. 219. Reza A. Ghiladi, Hong-wei Huang, Pierre Moënne-Loccoz, Jay Stasser, Ninian J. Blackburn, Amina S. Woods, Robert J. Cotter, Christopher D. Incarvito, Arnold L. Rheingold, and Kenneth D. Karlin, "A Heme-Cu/Dioxygen Adduct Formation Relevant to Cytochrome c Oxidase: Spectroscopic Characterization of [(⁶L)Fe^III-(O₂^2-)-Cu^II]⁺ ", J. Biol. Inorg. Chem. , 2005, 10, 63-77. 218. Fry, H. C.; Hoertz, P. G.; Wasser, I. M.; Karlin, K. D.; Meyer, G. J. "Efficient Photodissociation of O₂ from Synthetic Heme/M (M = Fe, Cu) Complexes", J. Am. Chem. Soc. 2004, 126, 16712-16713. 217. Wasser, Ian M.; Fry, H. Christopher; Hoertz, Paul G.; Meyer, Gerald J.; Karlin, Kenneth D. "Photochemical Organic Oxidations and Dechlorinations with a μ-Oxo Bridged Heme/Non-Heme Diiron Complex", Inorg. Chem., 2004, 43, 8272-8281. 216. Karlin, K. D.; Kim, E. "Ligand Influences in Heme-Copper O₂-Chemistry as Synthetic Models for Cytochrome c Oxidase", Chem. Lett. 2004, 33, 1226-1231. 215. Kim, E.; Shearer, J.; Lu, S.; Moënne-Loccoz, P.; Helton, M. E.; Kaderli, S.; Zuberbühler, A. D.; Karlin, K. D. "Heme/Cu/O₂ Reactivity: Change in Fe^III-(O₂^2-)-Cu^II Unit Peroxo Binding Geoemetry Effected by Tridentate Copper Chelation", J. Am. Chem. Soc. 2004, 126, 12716-12717. 214. Hatcher, L. Q.; Karlin, K. D. "Oxidant types in copper-dioxygen chemistry: the ligand coordination defines the Cu_n-O₂ structure and reactivity" J. Biol. Inorg. Chem. 2004, 9, 669-683. 213. Lucchese, B.; Humphreys, K. J.; Lee, D.-H.; Incarvito, C. D.; Sommer, R. D.; Rheingold, A. L.; Karlin, K. D. "Mono-, Bi-, and Trinuclear Cu^II-Cl Containing Products Based on the Tris(2-Pyridylmethyl)amine Chelate Derived from Copper(I) Complex Dechlorination Reactions of Chloroform" Inorg. Chem. 2004, 43, 5987-5998. 212. Liang, H.-C.; Henson, M. J.; Hatcher, L. Q.; Vance, M. A.; Zhang, C. X.; Lahti, D.; Kaderli, S.; Sommer, R. D.; Rheingold, A. L.; Zuberbühler, A. D.; Solomon, E. I.; Karlin, K. D. "Solvent Effects on the Conversion of Dicopper(II) -η²:η²-Peroxo to Bis-μ-oxo Dicopper(III) Complexes: Direct Probing of the Solvent Interaction" Inorg. Chem. 2004, 43, 4115-4117. 211. Wick, P. K.; Karlin, K. D.; Suzuki, M.; Zuberbühler, A. D. "Dicopper peroxo complexes: low temperature stopped-flow reaction kinetics of [(BQPA)Cu^I]⁺ and [(Me₂-TMPA)Cu^I]⁺", Micron, 2004, 35, 137-139. 210. Kim, E.; Chufán, E. D.; Kamaraj, K.; Karlin, K. D. “Synthetic Models for Heme–Copper Oxidases? Chem. Rev. 2004, 104, 1077-1133. 209. Lee, D.-H.; Lucchese, B.; Karlin, K. D. “Multimetal Oxidases? Chapter?.17, pp. 437-457, Volume 8, Bio-coordination Chemistry (Editors: Que, L.; Tolman, W. B.), in Comprehensive Coordination Chemistry II (McCleverty, J. A.; Meyer, T. J., Editors-in-Chief). Elsevier: Oxford, UK, 2004. 208. Ian M. Wasser, Constantinus F. Martens, Claudio N. Verani, Eva Rentschler, Hong-wei Huang, Pierre Möenne-Loccoz, Lev N. Zakharov, Arnold L. Rheingold and Kenneth D. Karlin, "Synthesis and spectroscopy of μ-oxo bridged heme/non-heme diiron complexes: Models for the active site of nitric oxide reductase.", Inorg. Chem. 2004, 43, 651-662. 207. Eduardo E. Chufán and Kenneth D. Karlin, "An Iron-Peroxo Porphyrin Complex: New Synthesis and Reactivity Toward a Cu(II) Complex Giving a Heme-Peroxo-Copper Adduct", J. Am. Chem. Soc. 2003, 125, 16160-16161. 206. Shearer, Jason; Zhang, Christiana X.; Hatcher, Lanying Q; Karlin, Kenneth D. "Distinguishing Rate Limiting Electron- vs. H-Atom Transfers in Cu₂(O₂) Mediated Oxidative N-Dealkylations: Application of Inter- vs. Intramolecular KIEs" J. Am. Chem. Soc. 2003, 125, 12670-12671. 205. Shin, Hyosul; Lee, Dong-Heon, Kang, Chan; Karlin, Kenneth D. "Electrocatalytic four-electron reductions of O₂ to H₂O with cytochrome c oxidase model compounds" Electrochimica Acta, 2003, 48, 4077-4082. 204. Fry, H. Christopher; Scaltrito, Donald V.; Karlin, Kenneth D.; Meyer, Gerald, M. "The Rate of O₂ and CO Binding to a Copper Complex, Determined by a "Flash-and-Trap" Technique, Exceeds that for Hemes", J. Am. Chem. Soc. 2003, 125, 11866-11871. 203. Thompson, David, W.; Kretzer, Ryan M.; Lebeau, Estelle L.; Scaltrito, D. V.; Ghiladi, R. A.; Lam, Kin-Chung; Rheingold, Arnold L.; Karlin, Kenneth D.; Meyer, Gerald J. "Synthesis, Characterization and Laser Flash Photolysis Reactivity of a Carbonmonoxy Heme Complex", Inorg. Chem. 2003, 42, 5211-5218. 202. Chen, Peng; Fujisawa, Kiyoshi; Helton, Matthew E.; Karlin, Kenneth D.; Solomon, Edward I. "Spectroscopy and Bonding in Side-On and End-On Cu₂(S₂) Cores: Comparison to Peroxide Analogues" J. Am. Chem. Soc. 2003, 125, 6394-6408. 201. Kamaraj, Kaliappan; Kim, Eunsuk; Galliker, Benedikt; Zakharov, Lev N.; Rheingold, Arnold L.; Zuberbühler, Andreas D.; Karlin, Kenneth D. "Copper(I) and Copper(II) Complexes Possessing Cross-Linked Imidazole-Phenol Ligands: Structures and Dioxygen Reactivity" J. Am. Chem. Soc. 2003, 125, 6028-6029. 200. Kretzer, Ryan M.; Ghiladi, Reza A.; Lebeau, Estelle, L.; Liang, Hong-Chang; Karlin, Kenneth D., “Synthesis and Characterization of Reduced Heme and Heme/Copper Carbonmonoxy Species? Inorg. Chem. 2003, 42, 3016-3025. 199. Henson, Mark J.; Vance, Michael A.; Zhang, Christiana Xin; Liang, Hong-Chang; Karlin, Kenneth D.; Solomon, Edward I. “Resonance Raman Investigation of Equitorial Ligand Donor Effects on the Cu₂O₂²⁺ Core in End-on and Side-on μ-Peroxo-Dicopper(II) and Bis-μ-oxo-Dicopper(III) Complexes? J. Am. Chem. Soc. 2003, 125, 5186-5192 198. Kim, Eunsuk; Helton, Matthew E.; Wasser, Ian M.; Karlin, Kenneth D.; Lu, Shen; Huang, Hong-wei; Moënne-Loccoz, P.; Incarvito, C. D.; Rheingold, A. L.; Honecker, Marcus; Kaderli, Susan; Zuberbühler, Andreas D., Superoxo, μ-peroxo and μ-oxo complexes from heme-O₂ and heme-copper-O₂ reactivity studies: Copper-ligand influences in cytochrome c oxidase models, Proc. Natl. Acad. Sci. U. S. A., 2003, 100, 3623-3628. 197. Zhang, C. X.; Kaderli, S.; Costas, M.; Kim, E.-i.; Neuhold, Y.-M.; Karlin, K. D.; Zuberbühler, A. D., Copper(I)-Dioxygen Reactivity of [(L)CuI]+ (L = tris(2-pyridymethyl)amine): Kinetic-Thermodynamic and Spectroscopic Studies Concerning the Formation of Cu-O2 and Cu2-O2 Adducts as a Function of Solvent Medium and 4-Pyridyl Ligand Substituent Variations, Inorg. Chem. 2003, 42, 1807-1824. 196. Helton, M. E.; Chen, P.; Paul, P. P.; Tyeklar, Z.; Sommer, R. D.; Zakharov, L. N.; Rheingold, A. L.; Solomon, E. I.; Karlin, K. D., Reaction of Elemental Sulfur with a Copper(I) Complex Forming a trans-m-1,2 End-On Disulfide Complex: New Directions in Copper-Sulfur Chemistry, J. Am. Chem. Soc., 2003, 125, 1160-1161 195. Zhang, C. X.; Liang, H.-C.; Kim, E.-i.; Shearer, J.; Helton, M. E.; Kim, E.; Kaderli, S.; Incarvito, C. D.; Zuberbuhler, A. D.; Rheingold, A. L.; Karlin, K. D., Tuning Copper-Dioxygen Reactivity and Exogenous Substrate Oxidations via Alterations in Ligand Electronics J. Am. Chem. Soc., 2003, 125, 634-635 194. Zhang, C. X.; Liang, H.-C.; Humphreys, K. J.; Karlin, K. D. Copper-Dioxygen Complexes and Their Roles in Biomimetic Oxidation Reactions?In Advances in Catalytic Activation of Dioxygen by Metal Complexes ( edited by Laszlo I. Simandi), Catalysis by Metal complexes, Vol. 26 (edited by Brian R. James and Piet W.N.M. van Leeuwen), Kluwer Academic Publishers, Dordrecht, Boston, London, 2003. Chapter 2, pp. 79-121. 193. Humphreys, K. J.; Karlin, K. D.; Rokita, S. E. Targeted Strand Scission of DNA Substrates by a Tricopper(II) Coordination Complexe, J. Am. Chem. Soc., 2002, 124, 8055-8066. 192. Humphreys, K. J.; Johnson, A. E.; Karlin, K. D.; Rokita, S. E. Oxidative Strand Scission of Nucleic Acids by a Multinuclear Copper(II) Complex. JBIC (J. Biol. Inorg. Chem.), 2002, 7, 835-842. 191. Humphreys, K. J.; Karlin, K. D.; Rokita, S. E. “Highly Efficient and Specific Strand Scission of DNA by a Dinuclear Copper Complex: Reactivity Comparisons of Complexes with Linked Tris(2-pyridylmethyl)amine Moieties?J. Am. Chem. Soc., 2002, 124, 6009-6019. 190. Liang, H.-C.; Zhang, C. X.; Henson, M. J.; Sommer, R. D.; Hatwell, K. R.; Kaderli, S.; Zuberbühler, A. D.; Rheingold, A. L.; Solomon, E. I.; Karlin, K. D. “Contrasting Copper-Dioxygen Chemistry Arising from Alike Tridentate Trialkylamine Copper(I) Complexes? J. Am. Chem. Soc., 2002, 124, 4170-4171 189. Ghiladi, R. A.; Karlin, K. D. “Low-Temperature UV-Visible and NMR Spectroscopic Investigations of the O2-Binding to (6L)FeII, a Ferrous Heme Bearing Covalently Tethered Axial Pyridine Ligands? Inorg. Chem., 2002, 41, 2400-2407. 188. Wasser, I. M.; de Vries, S.; Moënne-Loccoz, P.; Schröder, I.; Karlin, K. D. "Nitric Oxide in Biological Denitrification: Fe-Cu Metalloenzyme and Metal Complex NOX Redox Chemistry", Chem. Rev., 2002, 102, 1201-1234. (Invited article; special thematic issue on Nitric Oxide). 187. Liang, H.-C.; Kim, E.; Incarvito, C. D.; Rheingold, A. L.; Karlin, K. D. “A Bis-Acetonitrile Two-Coordinate Copper(I) Complex: Synthesis and Characterization of Highly Soluble B(C6F5)4? Salts of [Cu(MeCN)2]+ and [Cu(MeCN)4]+.? Inorg. Chem., 2002, 41, 2209-2212. 186. Ghiladi, R. A.; Kretzer, R. M.; Guzei, I.; Rheingold, A. L.; Neuhold, Y.-M.; Hatwell, K. R.; Zuberbühler, A. D.; Karlin, K. D. ?F8TPP)FeII-O2 Reactivity Studies {F8TPP = tetrakis(2,6-difluorophenyl)porphyrinate(2?}: Spectroscopic (UV-Visible and NMR) and Kinetic Study of Solvent-Dependent (Fe/O2 = 1:1 or 2:1) Reversible O2-Reduction and Ferryl Formation? Inorg. Chem, 2001, 40, 5754-5767. 185. Itoh, S.; Bandoh, H.; Nakagawa, M.; Nagatomo, S.; Kitagawa, T.; Karlin, K. D.; Fukuzumi, S. “Formation, Characterization, and Reactivity of Bis(μ-oxo)dinickel(III) Complexes Supported by A Series of Bis[2-(2-pyridyl)ethyl]amine Ligands? J. Am. Chem. Soc., 2001, 123, 11168-11178. 184. Scaltrito, D. V.; Fry, H. C.; Showalter, B. M.; Thompson, D. W.; Liang, H.-C.; Zhang, C. X.; Kretzer, R. M.; Kim, E.-i.; Toscano, J. P.; Karlin, K. D.; Meyer, G. J., “Reversible Carbon Monoxide Photodissociation from Cu(I) Coordination Compounds? Inorg. Chem, 2001, 40, 4514-4515. 183. Rhames, F. C.; Blackburn, N. J.; Murthy, N. N.; Karlin, K. D., “Isocyanide Binding to the Copper(I) Centers of the Catalytic Core of Peptidylglycine Monooxygenase (PHMcc)? JBIC (J. Biol. Inorg. Chem.), 2001, 6, 567-577. 182. Ghiladi, R. A.; Hatwell, K. R.; Karlin, K. D.; Huang, H.-w.; Moënne-Loccoz, P.; Krebs, C.; Marzilli, L. A.; Cotter, R. J.; Kaderli, S.; Zuberbühler, A. D. “Dioxygen Reactivity of Mononuclear Heme and Copper Components Yielding a High-Spin Heme-Peroxo-Cu Complex? J. Am. Chem. Soc., 2001, 123, 6183-6184. 181. Humphreys, K. J.; Karlin, K. D.; Rokita, S. E. “Recognition and Strand Scission at Junctions between Single- and Double-Stranded DNA by a Trinuclear Copper Complex? J. Am. Chem. Soc., 2001, 123, 5588-5589. 180. Schatz, M.; Becker, M.; Thaler, F.; Hampel, F.; Schindler, S.; Jacobson, R. R.; Tyeklár, Z.; Murthy, N. N.; Ghosh, P.; Chen, Q.; Zubieta, J.; Karlin, K. D. “Copper(I) Complexes, Copper(I)/O2 Reactivity and Copper(II) Complex Adducts, with a Series of Tetradentate Tripyridyl-Alkylamine Tripodal Ligands? Inorg. Chem. 2001, 40, 2312-2322. 179. Barton, J. K.; Karlin, K. D. “Bio-inorganic Chemistry: New advances, new directions and new investigators. Editorial overview.? Current Opinion Chemical Biology, 2001, 5, 165-167. Overview/introduction for 8 articles invited/edited; special section of the April issue of this journal. 178. Barton, Jacqueline K.; Karlin, Kenneth D.; Editors. “Bio-Inorganic Chemistry: New Advances, New Directions and New Investigators?[In: Curr. Opin. Chem. Biol., 2001; 5(2)], 62 pp.. 177. Zhang, C. X.; Liang, H.-C.; Kim, E.-i.; Gan, Q.-F.; Tyeklár, Z.; Lam, M.; Rheingold, A. L.; Kaderli, S.; Zuberbühler, A. D.; Karlin, K. D., “Dioxygen Mediated oxo-transfer to an amine and oxidative N-dealkylation chemistry with a dinuclear copper complex? Chem. Commun., 2001, 631-632. 176. Murthy, N. N.; Mahroof-Tahir, M.; Karlin, K. D. “Dicopper(I) Complexes of Unsymmetrical Binucleating Ligands and their Dioxygen Reactivity? Inorg. Chem., 2001, 40, 628-635. 175. Liang, H.-C.; Karlin, K. D.; Dyson, R.; Kaderli, S.; Jung, B.; Zuberbühler, A. D. “Dioxygen-Binding Kinetics and Thermodynamics of a Series of Dicopper(I) Complexes with Bis[2-(2-pyridyl)ethyl]amine Tridentate Chelators Forming Side-On Peroxo Bridged Dicopper(II) Adducts?Inorg. Chem. 2000, 39, 5884-5894. 174. Moënne-Loccoz, P.; Richter, O.-M. H.; Huang, H.-w.; Wasser, I. M. Ghiladi, R. A.; Karlin, K. D.; de Vries, S. “Nitric Oxide Reductase from Paracoccus denitrificans Contains an Oxo-Bridged Heme-Non-Heme Diiron Center? J. Am. Chem. Soc., 2000, 122,9344-9345. 173. Ju, T. D.; Woods, A. S.; Cotter, R. J.; Moënne-Loccoz, P.; Karlin, K. D. “Dioxygen and Nitric Oxide Reactivity of a Reduced Heme/Non-Heme Diiron(II) Complex [(5L)FeII…FeII-Cl]+. Using a Tethered Tetraarylporphyrin for the Development of an Active Site Reactivity Model for Bacterial Nitric Oxide Reductase? Inorg. Chim. Acta, 2000, 297, 362-372. 172. Kopf, M.-A.; Karlin, K. D. "Models of Copper Enzymes and Heme-Copper Oxidases", In Biomimetic Oxidations; B. Meunier, Ed.; Imperial College Press: London, 2000; Ch. 7, pp 309-362. 171. Feiters, M. C.; Klein Gebbink, R. J. M.; Sol? V. A.; Nolting, H.-F.; Karlin, K. D.; Nolte, R. J. M. “X-ray Absorption Spectroscopic Studies of the Cu(I) Complexes of Crown Ether Appended Bis-{(2-pyridyl)ethyl}amines and Their Dioxygen Adducts? Inorg. Chem., 1999, 38, 6171-6180. 170. Klein Gebbink, R. J. M.; Martens, C. F.; Kenis, P. J. A.; Jansen, R. J.; Nolting, H.-F.; Sol? V. A.; Feiters, M. C.; Karlin, K. D.; Nolte, R. J. M., "Synthesis, Structure and Reactivity of Copper Dioxygen Complexes Derived from Molecular Receptor Ligands", Inorg. Chem., 1999, 38, 5755-5768. 169. Karlin, K. D.; Gan, Q.-f.; Tyeklár, Z. “Dioxygen-Copper Reactivity at Trinuclear Centers: Formation of Hexanuclear and Mixed-Valent Adducts?Chem. Commun., 1999, 2295-2296. 168. Ghiladi, R. A.; Ju, T. D.; Lee, D.-H.; Moënne-Loccoz, P.; Kaderli, S.; Neuhold, Y.-M.; Zuberbühler, A. D.; Woods, A.S.; Cotter, R.J.; Karlin, K. D. “Formation and Characterization of a High-Spin Heme-Copper Dioxygen (Peroxo) Complex? J. Am. Chem. Soc., 1999, 121, 9885-9886. 167. Kopf, M.-A.; Karlin, K. D., “Dioxygen Reactivity of Reduced Heme and Heme-Copper Complexes Utilizing Tetra-arylporphryinates Tethered with both a Pyridyl Axial Ligand and N,N-bis[2-(2-pyridyl)ethyl]amine Chelate? Inorg. Chem., 1999, 38, 4922-4923. 166. Kopf, M.-A.; Neuhold, Y.-M.; Zuberbühler, A. D.; Karlin, K. D. “Oxo and Hydroxo-Bridged Heme-Copper Assemblies from Acid-Base or Metal-Dioxygen Chemistry? Inorg. Chem., 1999, 38, 3093-3102. 165. Ju, T. D.; Ghiladi, R. A.; Lee, D.-H.; van Strijdonck, G. P. F.; Woods, A. S.; Cotter, R. J.; Young, Jr., V. G.; Karlin, K. D. “Dioxygen Reactivity of Fully Reduced [(L)FeII…CuI]+ Complexes Utilizing Tethered Tetraarylporphyrinates: Active-Site Models for Heme-Copper Oxidases? Inorg. Chem., 1999, 38, 2244-2245. 164. Becker, M.; Schindler, S.; Karlin, K. D.; Kaden, T. A.; Kaderli, S.; Palanch? T.; Zuberbühler, A. D. “Intramolecular Ligand Hydroxylation: Mechanistic High Pressure Studies on the Reaction of a Dinuclear Copper(I) Complex with Dioxygen? Inorg. Chem., 1999, 38, 1989-1995. 163. Liang, H.-C., Dahan, M.; Karlin, K. D. “Dioxygen-activating bio-inorganic model complexes? Current Opinion in Chemical Biology, 1999, 3, 168-175. 162. Corsi, D. M.; Murthy, N. N.; Young, Jr., V. G.; Karlin, K. D. “Synthesis, Structure and Solution NMR-Studies of Cyanide-Copper(II) and Cyanide-Bridged Fe(III)-Cu(II) Complexes? Inorg. Chem., 1999, 38, 848-858. 161. Pidcock, E.; DeBeer, S.; Obias, H. V.; Hedman, B.; Hodgson, K. O.; Karlin, K. D.; Solomon, E. I. “A Study of Solid [{MePY2)}2(O2)]2+ using Resonance Raman and X-ray Absorption Spectroscopies; an Intermediate Cu2O2 Core Structure or a Solid Solution?? J. Am. Chem. Soc., 1999, 121, 1870-1878. 160. Karlin, K. D.; Zuberbühler, A. D., "Formation, Structure, and Reactivity of Copper Dioxygen Complexes", In Bioinorganic Catalysis: Second Edition, Revised and Expanded. (Reedijk, J.; Bouwman, E.; Eds.), Marcel Dekker: New York, 1999, Ch. 14, 469-534. 159. Pidcock, E.; Obias, H. V.; Abe, Masaaki; Liang, H.-C.; Karlin, K. D.; Solomon, E. I. “Spectroscopic and Theoretical Studies of Oxygenated Dicopper(I) Complexes Containing Hydrocarbon-linked Bis[2-(2-pyridyl)ethyl]amine units: Investigation of a Butterfly [Cu2-m-h2:h2)(O2)]2+ Core? J. Am. Chem. Soc., 1999, 121, 1299-1308. 158. Obias, H. V.; Lin, Y.; Murthy, N. N.; Pidcock, E.; Solomon, E. I. Ralle, M.; Blackburn, N. J.; Neuhold, Y.-M.; Zuberbühler, A. D.; Karlin, K. D. “Peroxo-, Oxo-, and Hydroxo-Bridged Dicopper Complexes: Observation of Exogenous Hydrocarbon Substrate Oxidation? J. Am. Chem. Soc., 1998, 120, 12960-12961. 157. Karlin, S.; Zhu, Z.-Y.; Karlin, K. D. "Extended Metal Environments of Cytochrome c Oxidase Structures", Biochemistry, 1998, 37, 17726-17734. 156. Obias, H. V.; van Strijdonck, G. P. F.; Ralle, M.; Blackburn, N. J.; Karlin, K. D., "Heterobinucleating Ligand Induced Structural and Chemical Variations in [(L)FeIII-O-CuII]+ m-Oxo Complexes", J. Am. Chem. Soc., 1998, 120, 9696-9697. 155. Root, D. E.; Mahroof-Tahir, M.; Karlin, K. D.; Solomon, E. I., "Effect of Protonation on Peroxo-Copper Bonding: Spectroscopic and Electronic Structure Study of [Cu2(UN-O-)(OOH)]2+", Inorg. Chem., 1998, 37, 4838-4848. 154. Pidcock, E.; Obias, H. V.; Zhang, C. X.; Karlin, K. D.; Solomon, E. I. "Investigation of the Reative Oxygen Intermediate in an Arene Hydroxylation Reaction Performed by Xylyl-bridged Binuclear Complexes", J. Am. Chem. Soc., 1998, 120, in press. 153. Karlin, K. D.; Zhu, Z-Y.; Karlin, S., "The Envionment of Multinuclear Copper Metal Linkages in Protein Structures", JBIC, J. Biol. Inorg. Chem., 1998, 3, 172-187. 152. Karlin, K. D.; Lee, D.-H.; Obias, H. V.; Humphreys, K. J., "Copper-Dioxygen Complexes: Functional Models for Proteins", Pure Appl. Chem., 1998, in press. 151. Karlin, S.; Zhu, Z-Y.; Karlin, K. D., "The Extended Environment of Mononuclear Metal Centers in Protein Structures", Proc. Natl. Acad. Sci. USA, 1997, 94, 14225-14230. 150. Lee, D.-H.; Murthy, N. N.; Lin, Y.; Nasir, N. S.; Karlin, K. D., "Copper Ion Complexes with Derivatized Chelating Pterin Ligands", Inorg. Chem., 1997, 119, 6328-6334. 149. Lee, D.-H.; Murthy, N. N.; Karlin, K. D., "Binuclear Copper Complexes Based on the 6,6'-Bis[[bis(2-pyridylmethyl)amino]methyl]-2,2'-bipyridine Ligand", Inorg. Chem., 1997, 119, 5785-5792. 148. Comba, P.; Hilfenhaus, P.; Karlin, K. D. "Modeling of End-on m-Peroxo Dicopper(II) Complexes", Inorg. Chem., 1997, 119, 2309-2313. 147. Nanthakumar, A.; Fox, S.; Murthy, N. M., Karlin, K. D., "Inferences from the 1H-NMR Spectroscopic Study of an Antiferromagnetically Coupled Heterobinuclear Fe(III)-(X)-Cu(II) S = 2 System (X = O2-, OH-)," J. Am. Chem. Soc., 1997, 119, 3898-3906. 146. Karlin, K. D.; Kaderli, S.; Zuberbühler, A. D, "Kinetics and Thermodynamics of Copper(I)/Dioxygen Interaction", Acc. Chem. Res., 1997, 30, 139-147. 145. Frey, S. T.; Murthy, N. N.; Weintraub, S. T.; Thompson, L. K.; Karlin, K. D., "Hydrolysis of Unactivated Esters and Acetonitrile Hydration by a Hydroxo-Dicopper(II) Complex, Inorg. Chem., 1997, 36, 956-957. 144. Karlin, K. D.; Lee, D.-H.; Kaderli, S.; Zuberbühler, A. D., "Copper Dioxygen Complexes Stable at Ambient Temperature: Optimization of Ligand Design and Solvent" Chem. Commun., 1997, 475-476. 143. K. Leidenberger, M. vom Orde, B. Fischer, M.-A. Kopf, D.-H. Lee and K. D. Karlin, "Chemical Models for the Active Centre of Copper Containing Amino Acid Hydroxylases", Chem. Biol. Pteridines Folates, Proc. 11th Int. Symp. Pteridines and Folates' Eds.: W. Pfleiderer, H. Rokos, Blackwell Science: Berlin, Vienna, Fed. Rep. Ger., 1997, p. 61-64. 142. Klein Gebbink, R. J. M.; Martens, C. F.; Feiters, M. C.; Karlin, K. D.; Nolte, R. J. M. "Novel Molecular Receptors Capable of Forming Cu2-O2 Complexes. Effect of Preorganization on O2-Binding.", Chem. Commun., 1997, 389-390. 141. Karlin, K. D.; Tolman, W. B.; Kaderli, S.; Zuberbühler, A. D., "Kinetic and Thermodynamic Parameters of Copper-Dioxygen Interaction with Different Oxygen Binding Modes", J. Molec. Catal. A., 1997, 117(1-3), 215-222. 140. Murthy, N. N.; Karlin, K. D.; Bertini, I.; Luchinat, C., "NMR and Electronic Relaxation in Paramagnetic Dicopper(II) Compounds", J. Am. Chem. Soc., 1997, 119, 2156-2162. 139. Jung, B.; Karlin, K. D.; Zuberbühler, A. D. "Formation and Interconversion of End-on and Side-on m-Peroxo Dicopper(II) Complexes," J. Am. Chem. Soc., 1996, 118, 3763-3764. 138. Frey, S. T.; Sun, H. H. J.; Murthy, N. N.; Karlin, K. D. "A New Trinuclear Copper Complexes and Its Reactions with Plasmid DNA", Inorganica Chim Acta, 1996, 242, 329-338. 137. Fox, S.; Nanthakumar, A.; Wikström, M.; Karlin, K. D.; Blackburn, N. J. "XAS Structural Comparisons of Reversibly Interconvertible Oxo- and Hydroxo-Bridged Heme-Copper Oxidase Model Compounds", J. Am. Chem. Soc., 1996, 118, 24-34. 136. Martens, C. F.; Murthy, N. N.; Obias, H. V.; Karlin, K. D. "Oxo-Bridged Heme/Non-heme Iron Complexes" J. Chem. Soc. Chem. Commun. 1996, 629-630. 135. Lee, D.-H.; Murthy, N. N.; Karlin, K. D. "Copper(I)/Dioxygen Reactivity with Dinuclear Compounds: Catalytic Oxygenation and Oxo-Transfer to a Ketone". Inorg. Chem. 1996, 35, 804-805. 134. Lee, D.-H.; Wei, N.; Murthy, N. N.; Tyeklár, Z.; Karlin, K. D.; Kaderli, S.; Jung, B.; Zuberbühler, A. D. "Reversible O2-Binding to a Dinuclear Copper(I) Complex with Linked TMPA {tris(2-pyridylmethyl)amine} Units: Kinetic-Thermodynamic Comparisons with Mononuclear Analogues" J. Am. Chem. Soc., 1995, 117, 12498-12513. 133. Sanyal, I.; Karlin, K. D. "Metalloproteins and Dioxygen Metabolism" In Handbook of Metal-Ligand Interactions in Biological Fluids: Bioinorganic Chemistry, Vol. 1, G. Berthon, Ed., Marcel Dekker: New York, Part Two, Chapter 1, Section B14, pp. 284-294, 1995. 132. Reedy, B. J.; Murthy, N. N.; Karlin, K. D.; Blackburn, N. J. "Isocyanides as Ligand-Directed Indicators of Cu(I) Coordination in Copper Proteins. Probing the Inequivalence of the Cu(I) Centers in Reduced Dopamine-b-monooxygenase" J. Am. Chem. Soc., 1995, 117, 9826-9831. 131. Fox, S.; Karlin, K. D. "Dioxygen Reactivity in Copper Proteins and Complexes" In Reactive Oxygen in Biochemistry, Valentine, J. S.; Foote, C. S.; Greenberg, A.; Liebman, J. F., Eds., Blackie Academic & Professional, Chapman & Hall: Glasgow, 1995, Chapter 4, pp.188-231. 130. Murthy, N. N.; Karlin, K. D., "Biomimetic Copper-Dioxygen Chemistry: Reversible O2-Binding and Mechanistic Insights into Cu(I)/O2 Mediated Arene Hydroxylation and Amide Hydrolysis", In Mechanistic Bioinorganic Chemistry, "Advances in Chemistry Series, Volume 246, H. H. Thorp, V. L. Pecoraro, Eds., American Chemical Society, Washington, D. C., pp. 165-193, 1995. 129. Sanyal, I.; Ghosh, P.; Karlin, K. D. "Mononuclear Copper(II)-Acylperoxo Complexes". Inorg. Chem. 1995, 34, 3050-3056. 128. Nanthakumar, A..; Fox, S.; Karlin, K. D. "Copper-Dioxygen Reactivity Involved in the Formation of m-oxo [[(P)FeIII-O-CuII(L)]+ Heterodinuclear Complexes (P = porphyrinate, L = tetradentate ligand), and Novel Synthesis of Square Planar (P)-FeII Species", J. Chem. Soc., Chem. Commun., 1995, 499-501. 127. Karlin, K. D.; Fox., S.; Nanthakumar, A.; Murthy, N. N.; Wei, N.; Obias, H. V.; Martens, C. F. "Copper-Dioxygen Chemistry and Modeling the Fe-Cu Center in Cytochrome c Oxidase", Pure Appl. Chem., 1995, 67, 289-296. 126. Wei, N.; Murthy, N. N.; Karlin, K. D. "Chemistry of Pentacoordinated [LCuII-Cl]+ Complexes with Quinolyl Containing Tripodal Tetradentate Ligands L", Inorg. Chem., 1994, 33, 6093-6100. 125. Wei, N.; Lee, D.-H.; Murthy, N. N.; Tyeklár, Z.; Karlin, K. D.; Kaderli, S.; Jung, B.; Zuberbühler, A. D. "Kinetic Preference without Thermodynamic Stabilization in the Intra- vs Intermolecular Formation of Copper-Dioxygen Complexes", Inorg. Chem., 1994, 33, 4625-4626. 124. Karlin, K. D.; Nanthakumar, A.; Fox, S.; Murthy, N. N.; Ravi, N.; Huynh, B. H.; Orosz, R. D.; Day, E. P. "X-ray Structure and Physical Properties of the Oxo-Bridged Complex [(F8-TPP)Fe-O-Cu(TMPA)]+, F8-TPP = tetrakis(2,6-difluorophenyl)porphyrinate(2-), TMPA = tris(2-pyridylmethyl)amine: Modeling the Cytochrome c Oxidase Fe-Cu Heterodinuclear Active Site.", J. Am. Chem. Soc., 1994, 116, 4753-4763. 123. Conry, R. R.; Karlin, K. D. "Dioxygen & Related Ligands", Encyclopedia of Inorganic Chemistry, R. B. King, Ed.-in-Chief; R. H. Crabtree, Sect. Ed., John Wiley & Sons: New York, pp 1036-1040, 1994. 122. Conry, R. R.; Karlin, K. D. "Copper: Inorganic and Coordination Chemistry", Encyclopedia of Inorganic Chemistry, R. B. King, Ed.-in-Chief; R. H. Crabtree, Sect. Ed., John Wiley & Sons: New York, pp 829-840, 1994. 121. Wei, N.; Murthy, N. N.; Chen, Q.; Zubieta, J.; Karlin, K. D. "Copper(I)/Dioxygen Reactivity of Mononuclear Complexes with Pyridyl and Quinolyl Tripodal Tetradentate Ligands: Reversible Formation of Cu:O2 = 1:1 and 2:1 Adducts", Inorg. Chem. 1994, 33, 1953-1965. 120. Wei, N.; Murthy, N. N.; Tyeklár, Z.; Karlin, K. D. "Copper(I) Complexes with Pyridyl and Imidazolyl Contanining Tripodal Tetradentate Ligands, and Their Reactions with Dioxygen", Inorg. Chem. 1994, 33, 1177-1183. 119. Karlin, K. D.; Nasir, M. S.; Cohen, B. I.; Cruse, R. W.; Kaderli, S.; Zuberbühler, A. D. "Reversible Dioxygen Binding and Aromatic Hydroxylation in O2-Reactions with Substituted Xylyl Dinuclear Copper(I) Complexes: Syntheses, Low-Temperature Kinetic/Thermodynamic and Spectroscopic Investigations of a Copper Monooxygenase Model System." J. Am. Chem. Soc., 1994, 116, 1324-1336. 118. Karlin, K. D.; Tyeklár, Z. "Functional Biomimics for Copper Proteins Involved in Reversible O2-Binding, Substrate Oxidation/Oxygenation and Nitrite Reduction", Advances in Inorganic Biochemistry, 1994, 9, 123-172. 117. Sanyal, I.; Karlin, K. D.; Strange, R. W.; Blackburn, N. J. "Chemistry & Structural Studies on the Dioxygen-Binding Copper-1,2-Dimethylimidazole System", J. Am. Chem. Soc., 1993, 115, 11259-11270. 116. Fox, S.; Nanthakumar, A.; Wei, N.; Murthy, N. N.; Karlin, K. D. "Investigations of Dioxygen Reactivity with Synthetic Models of the Metalloproteins Hemocyanin and Cytochrome c Oxidase", Pure Appl. Chem., 1993, 65, 2335-2342. 115. Sanyal, I.; Murthy, N. N.; Karlin, K. D., "A Dicopper(I) Complex and Its Oxygenation Chemistry Using a Dinucleating Ligand with Pendant Alkene Group", Inorg. Chem. 1993, 32, 5330-5337. 114. Nanthakumar, A.; Fox., S.; Nasir, S. M.; Ravi, N.; Huynh, B. H.; Orosz, R. D.; Day, E. P.; Hagen, K. S.; Karlin, K. D., "Dioxygen Reactivity Models for Cytochrome c Oxidase: Synthesis and Characterization of Oxo and Hydroxo-Bridged Porphyrin-Iron/Copper Dinuclear Complexes", In The Activation of Dioxygen and Homogeneous Catalytic Oxidation, D. H. R. Barton, A. E. Martell and D. T. Sawyer, Eds. . Plenum Press: New York, 1993, pp 381-394. 113. Murthy, N. N.; Mahroof-Tahir, M.; Karlin, K. D., "Facile Amide Hydrolysis Effected by Dinuclear Copper Complexes", to J. Am. Chem. Soc., 1993, 115, 10404-10405. 112. Karlin, K. D.; Wei, N.; Jung, B.; Kaderli, S.; Niklaus, P.; Zuberbühler, A. D. "Kinetics and Thermodynamics of Formation of Copper-Dioxygen Adducts: Oxygenation of Mononuclear Copper(I) Complexes Containing Tripodal Tetradentate Ligands", J. Am. Chem. Soc., 1993, 115, 9506-9514. 111. Nanthakumar, A.; Fox., S.; Murthy, N. N.; Karlin, K. D.; Ravi, N.; Huynh, B. H.; Orosz, R. D.; Day, E. P.; Hagen, K. S.; Blackburn, N. J. "Oxo and Hydroxo-Bridged (Porphyrin)Iron(III)-Copper(II) Species as Cytochrome c Oxidase Models: Acid-Base Interconversions and X-ray Structure of the Fe(III)-(O2-)-Cu(II) Complex", J. Am. Chem. Soc., 1993, 115, 8513-8514. 110. Gultneh, Y.; Farooq, A.; Karlin, K. D.; Liu, Shuncheng; Zubieta, J. "Structure and Reactions of an Eight-Coordinate Mn(II) Complex: [Mn(TMPA)2](ClO4)2 (TMPA = tris[(2-pyridyl)methyl]amine", Inorg. Chim. Acta, 1993, 311, 171-175. 109. Karlin, K. D. "Metalloenzymes, Structural Motifs and Inorganic Models", Science, 1993, 261, 701-708. 108. Murthy, N. N.; Karlin, K. D. "A Dinuclear Zinc Hydroxide Complex which Traps Atmospheric Carbon Dioxide: Formation of a Tri-zinc Complex with a Triply Bridging Carbonate Group", J. C. S. Chem. Commun., 1993, 1236-1238. 107. Jiang, F.; Karlin, K. D.; Peisach, J. "An Electron Spin Echo Envelope Modulation (ESEEM) Study of Electron-Nuclear Hyperfine and Nuclear Quadrupole Interactions of dz2 Ground State Cu(II) Complexes with Substituted Imidazoles", Inorg. Chem., 1993, 32, 2576-2582. 106. Mahroof-Tahir, M.; Karlin, K. D.; Chen, Qin; Zubieta J. "Phosphate Ester Coordination to Dicopper(II) Compounds; X-ray Structure of a Bis(4-nitrophenyl)phosphato Bridged Dicopper(II) Complex", Inorg. Chim. Acta., 1993, 207, 135-138. 105. Martens, C. F.; Klein Gebbink, R. J. M.; Kenis, P. J. A.; Schenning, A. P. H. J.; Feiters, M. C.; Ward, J. L.; Karlin, K. D.; Nolte, R. J. M., In Bioinorganic Chemistry of Copper, Karlin, K. D., Tyeklár, Z., Eds., Chapman & Hall: New York, 1993, pp. 374-381. 104. Tyeklár, Z.; Karlin, K. D., "Functional Models for Hemocyanin and Copper Monooxygenases", In Bioinorganic Chemistry of Copper, Karlin, K. D., Tyeklár, Z., Eds., Chapman & Hall: New York, 1993, pp. 277-291. 103. Tyeklár, Z.; Jacobson, R. R.; Wei, N.; Murthy, N. N.; Zubieta, J.; Karlin, K. D. "Reversible Reaction of O2 (and CO) with a Copper(I) Complex: X-ray Structures of Relevant Mononuclear Cu(I) Precursor Adducts and the trans-m-1,2-Peroxo-Dicopper(II) Product", J. Am. Chem. Soc. 1993, 115, 2677-2689. 102. Jiang, F.; Conry, R. R.; Bubacco, L.; Tyeklár, Z.; Jacobson, R. R.; Karlin, K. D.; Peisach, J. "Crystal Structure and Electron Spin Echo Envelope Modulation Study of [Cu(II)(TEPA)(NO2)]PF6 (TEPA = tris-[2-(2-pyridyl)ethyl]amine): A Potential Model for the Nitrite Derivative of Hemocyanin", J. Am. Chem. Soc. 1993, 115, 2093-2102. 101. Nasir, M. S.; Jacobson, R. R.; Zubieta, J.; Karlin, K. D. "Pyridine Ligand Donor Substituent Effects Upon Structure, Redox Properties and O2-Reactivity of Xylyl Dinuclear Copper(I) Complexes", Inorg. Chim. Acta, 1993,203, 5-7. 100. Karlin, K. D.; Tyeklár, Z.; Zuberbühler, A. D. "Formation, Structure and Reactivity of Copper Dioxygen Complexes" In Bioinorganic Catalysis (Reedijk, J., Ed.), Marcel Dekker: New York 1993, Chapter 9, pp 261-315. 99. Sanyal, I.; Mahroof-Tahir, M.; Nasir, M. S.; Ghosh, P.; Cohen, B. I.; Gultneh, Y.; Cruse, R. W.; Farooq, A.; Karlin, K. D.; Liu, S.; Zubieta, J. "Reactions of Dioxygen (O2) with Mononuclear Copper(I) Complexes: Temperature-Dependent Formation of Peroxo- or Oxo- (and Dihydroxo-) Bridged Dicopper(II) Complexes" Inorg. Chem. 1992, 31, 4322-4332. 98. Mahroof-Tahir, M.; Karlin, K. D. "A Dinuclear Mixed-Valence Cu(I)/Cu(II) Complex and Its Reversible Reaction with O2: Generation of A Superoxo-Dicopper(II) Species", J. Am. Chem. Soc. 1992, 114, 7599-7601. 97. Gultneh, Y.; Farooq, A.; Liu, Shuensheng; Karlin, K. D.; Zubieta, J. "Synthesis, Structure and Characterization of a Phenolate-Bridged Dimanganese(II) Complex of a Dinucleating Phenol Ligand", Inorg. Chem., 1992,31, 3607-3611. 96. Nanthakumar, A.; Nasir, M. S.; Karlin, K. D.; Ravi, N.; Huynh, B.H. "A Cytochrome c Oxidase Reactivity Model: Generation of a Peroxo-Bridged Iron/Copper Dinuclear Complex", J. Am. Chem. Soc. 1992, 114, 6564-6566. 95. Mahroof-Tahir, M.; Murthy, N. N.; Karlin, K. D.; Blackburn, N. J.; Shaikh, S. N.; Zubieta, J. "New Thermally Stable Hydroperoxo and Peroxo Copper Complexes", Inorg. Chem., 1992,31, 3001-3003. 94. Ling, J.; Farooq, A.; Karlin, K. D.; Loehr, T. M.; Sanders-Loehr, J. "Vibrational Spectroscopic Studies of a Hydroxo-Bridged Dinuclear Copper Complex, a Potential Model for Multi-Copper Proteins", Inorg. Chem., 1992, 31, 2552-2556. 93. Nasir, M. S.; Karlin, K. D.; Chen, Q.; Zubieta, J. "Copper(I) and Copper(II) Complexes of New Chelating Pterins", J. Am. Chem. Soc., 1992, 114, 2264-2265. 92. Karlin, K. D.; Tyekár, Z.; Farooq, A.; Haka, M. S.; Ghosh, P.; Cruse, R. W.; Gultneh, Y.; Hayes, J. C.; Zubieta, J. "Functional Modeling of Hemocyanins. Reversible Binding of O2 and CO to Dicopper(I) Complexes [Cu(I)2(L)]2+ (L = Dinucleating Ligand) and the Stucture of A Bis(Carbonyl) Adduct, [Cu(I)2(L)(CO)2]2+," Inorg. Chem., 1992, 31, 1436-1451. 91. Nasir, M. S.; Cohen, B. I.; Karlin, K. D. "Mechanism of Aromatic Hydroxylation in a Copper Monooxygenase Model System. The NIH Shift in Copper Chemistry", J. Am. Chem. Soc., 1992, 114, 2482-2494. 90. Baldwin, M. J.; Ross, P. K.; Pate, J. E.; Tyeklár, Z.; Karlin, K. D.; Solomon, E. I. "Spectroscopic and Theoretical Studies of an End-On Peroxide-Bridged Coupled Binuclear Copper(II) Model Complex of Relevance to the Active Sites of Hemocyanin and Tyrosinase" J. Am. Chem. Soc., 1991, 113, 8671-8679. 89. Paul, P. P.; Karlin, K. D., "Functional Modeling of Copper Nitrite Reductases: Reactions of NO2- or NO with Copper(I) Complexes", J. Am. Chem. Soc., 1991, 113, 6331-6332. 88. Karlin, K. D.; Wei, N.; Jung, B.; Kaderli, S.; Zuberbühler, A. D. ,"Kinetic, Thermodynamic and Spectral Characterization of the Primary Cu-O2 Adduct in a Reversibly Formed and Structurally Characterized Peroxo-Dicopper(II) Complex", J. Am. Chem. Soc., 1991, 113, 5868-5870. 87. Paul, P. P.; Tyeklár, Z.; Jacobson, R. R.; Karlin, K. D., "Reactivity Patterns and Comparisons in Three Classes of Synthetic Copper-Dioxygen {Cu2-O2} Complexes: Implication for Structure and Biological Relevance", J. Am. Chem. Soc., 1991, 113, 5322-5332. 86. Sanyal, I.; Strange, R. R.; Blackburn, N. J.; Karlin, K. D., "Formation of a Copper-Dioxygen Complex (Cu2-O2) Using Simple Imidazole Ligands", J. Am. Chem. Soc. 1991, 113, 4692-4693. [Highlighted in "Chemical & Engineering News", June 17, 1991.] 85. Tyeklár, Z.; Karlin, K. D "Biomimetic Binding and Acrtivation of Dioxygen with Copper Complexes", In Dioxygen Activation and Homogeneous Catalytic Oxidation, L. I. Simándi, Ed., Elsevier: Amsterdam, 1991, pp. 237-248. 84. Karlin, K. D.; Tyeklár, Z.; Farooq, A.; Jacobson, R. R.; Sinn, E.; Lee, D. W.; Bradshaw, J. E.; Wilson, L. J. "Peroxide (O22-) as a Bridging Ligand for Copper(II): Strong Exchange Coupling in Complexes Drived from Copper(I) and Dioxygen", Inorg. Chim. Acta, 1991, 182, 1-3. 83. Jacobson, R. R.; Tyeklár, Z.; Karlin, K. D.; Zubieta, J. "Fluoride as a Terminal and Bridging Ligand for Copper: Isolation and X-ray Crystallographic Characterization of Monomeric and Dimeric Complexes [CuII(TMPA)F]nn+ (n = 1, or 2; TMPA = Tris[(2-pyridyl)methyl]amine), Inorg. Chem., 1991, 30, 2035-2040. 82. Jacobson, R. R.; Tyeklár, Z.; Karlin, K. D, "Reaction of Organic Halides with [CuI(TMPA)(CH3CN)]PF6", Inorg. Chim. Acta, 1991, 181, 111-118. 81. Nasir, M. S.; Karlin, K. D.; McGowty, D.; Zubieta, J. "Unsymmetrical Dicopper Complexes. Direct Observation of Reversible O2-Binding in a Copper Monooxygenase Model System." J. Am. Chem. Soc. 1991, 113, 698-700. 80. Nasir, M. S.; Cohen, B. I.; Karlin, K. D. "Oxidative Dehalogenation During a Copper Complex Mediated Hydroxylation Reaction", Inorg. Chim. Acta, 1990, 176, 185-187. 79. Karlin, K. D.; Gan, Q.-F.; Farooq, A.; Liu, S.; Zubieta, J., "A Trinuclear Copper(I) Complex, Reaction with Dioxygen and the Formation of a Hexanuclear Copper(II) Cluster." Inorg. Chem. 1990, 29, 2549-2551. 78. Karlin, K. D.; Sanyal, I.; Farooq, A.; Jacobson, R. R.; Shaikh, S. N.; Zubieta, J. "Model for the Possible 'Endogenous' Bridge in Oxy-Hemocyanin: A Di-m-(OR)2-Bridged Dicopper(II) Complex (R = H, alkyl) with Low-Energy Charge-Transfer Absorption", Inorg. Chim. Acta, 1990, 174, 13-15. 77. Paul, P. P.; Tyeklár, Z.; Farooq, A.; Karlin, K. D.; Liu, S.; Zubieta, J., "Isolation and X-ray Structure of a Dinuclear Copper-Nitrosyl Complex" J. Am. Chem. Soc. 1990, 112, 2430-2432. 76. Karlin, K. D.; Gan, Q.-F.; Farooq, A.; Liu, S.; Zubieta, J., "Synthesis and X-Ray Crystal Structure of a Trinuclear Copper Cluster" Inorg. Chim. Acta 1989, 165, 37-39. 75. Tyeklár, Z.; Karlin, K.D. "Copper-Dioxygen Chemistry. A Bioinorganic Challenge", Acc. Chem. Res. 1989, 22, 241-248. 74. Pate, J. E.; Ross, P. K.; Thamann, T. J.; Reed, C. A.; Karlin, K. D.; Sorrell, T. N.; Solomon, E. I. "Spectroscopic Studies of the Charge Transfer and Vibrational Features of Binuclear Copper(II) Azide Complexes: Comparison to the Coupled Binuclear Copper Active Site in Met Azide Hemocyanin and Tyrosinase" J. Am. Chem. Soc. 1989, 111, 5198-5209. 73. Blackburn, N. J.; Strange, R. W.; Reedijk, J. Volbeda, A.; Farooq, A.; Karlin, K. D.; Zubieta, J. "X-Ray Absorption Edge Spectroscopy of Cu(I) Complexes. The Coordination Geometry of Cu(I) in the Reduced Forms of Copper Proteins and Their Derivatives with Carbon Monoxide" Inorg. Chem. 1989, 28, 1349-1357. 72. Tyeklár, Z.; Paul, P.P.; Jacobson, R.R.; Farooq, A.; Karlin, K.D.; Zubieta, J. "Dioxygen-Copper Reactivity. Comparisons of the Reactions of Electrophiles and Other Reagents with Three Classes of {Cu2-O2}n+ Species", J. Am. Chem. Soc., 1989, 111, 388-389. 71. Cruse, R.W.; Kaderli, S.; Karlin, K. D.; Zuberbühler, A.D. "Kinetic and Thermodynamic Studies on the Reaction of O2 with Two Dinuclear Copper(I) Complexes", J. Am. Chem. Soc., 1988, 110, 6882-6883. 70. Karlin, K. D.; Ghosh, P.; Cruse, R. W.; Farooq, A.; Gultneh, Y.; Jacobson, R. R.; Blackburn, N. J.; Strange, R. W.; Zubieta, J. "Dioxygen-Copper Reactivity: Generation, Characterization and Reactivity of a Hydroperoxo-Dicopper(II) Complex", J. Am. Chem. Soc. 1988, 110, 6769-6780. 69. Zuberbühler, A.D.; Cruse, R.W.; Kaderli, S.; Meyer, C.J.; Karlin, K.D. "Copper Mediated Hydroxylation of an Arene: Kinetics and Mechanism of the Reaction of a Dicopper(II) m-Xylyl Containing Complex with H2O2 to Yield a Phenoxo-Dicopper(II) Complex", J. Am. Chem. Soc. 1988, 110, 5020-5024. 68. Karlin, K. D.; Farooq, A.; Gultneh, Y.; Hayes, J. C.; Zubieta, J. "Synthesis and Stucture of a CO-Containing Phenoxo-Bridged Dicopper(I) Complex", Inorg. Chim. Acta, 1988, 153, 73-74. 67. Karlin, K. D.; Cohen, B. I.; Farooq, A.; Liu, S.; Zubieta J. "Copper Mediated Hydroxylation of a Modified Monooxygenases Model System", Inorg. Chim. Acta, 1988, 153, 9-11. 66. Tyeklar, Z.; Ghosh, P.; Karlin, K.D.; Farooq, A.; Cohen, B.I.; Cruse, R.W.; Gultneh, Y.; Haka, M.S.; Jacobson, R.R.; Zubieta, J. "Models for Copper Proteins: Reversible Binding and Activation of Dioxygen and the Reactivity of Peroxo and Hydroperoxo Dicopper(II) Complexes", In Metal Clusters in Proteins, L.Que, Ed., ACS Symposium Series No. 372; American Chemical Society: Washington, D.C. 1988, Chapter 5, pp 85-104. 65. Blackburn, N.J.; Strange, R.W.; Farooq, A.; Haka, M.S.; Karlin, K.D. "X-ray Absorption Studies of Three Coordinate Dicopper(I) Complexes and Their Dioxygen Adducts"., J. Am. Chem. Soc. 1988, 110, 4263-4272. 64. Jacobson, R. R.; Tyeklar, Z.; Karlin, K. D.; Liu, S.; Zubieta, J. "A Cu2-O2 Complex. Crystal Structure and Characterization of a Reversible Dioxygen Binding System", J. Am. Chem. Soc. 1988, 110, 3690-3692. 63. Karlin, K.D.; Haka, M.S.; Cruse, R.W.; Meyer, G.J.; Farooq, A.; Gultneh, Y.; Hayes, J.C.; Zubieta, J. "Dioxygen-Copper Reactivity. Reversible O2 and CO Binding to Structurally Characterized Dicopper(I) Complexes Containing Hydrocarbon-Linked Bis[2-(2-pyridyl)ethyl)]amine Units", J. Am. Chem. Soc., 1988, 110, 1196-1207. 62. Ghosh, P.; Tyeklar, Z.; Karlin, K.D.; Jacobson, R.R.; Zubieta, J. "Dioxygen-Copper Reactivity: X-ray Structure of an Acyl-Peroxo Dicopper(II) Complex J. Am. Chem. Soc. 1987, 109, 6889-6891. 61. Karlin, K.D.; Cohen, B.I.; Jacobson, R.R.; Zubieta, J. "Dioxygen-Copper Reactivity: Hydroxylation-Induced Methyl Migration in a Copper Monooxygenase Model System", J. Am. Chem. Soc., 1987, 109, 6194-6196. 60. Karlin, K. D.; Gultneh, Y. "Binding and Activation of Molecular Oxygen by Copper Complexes" Prog. Inorg. Chem. 1987, 35, 219-327. 59. Karlin, K. D.; Farooq, A.; Cruse, R. W.; Gultneh, P.; Ghosh, P.; Jacobson, R. R.; Zubieta, J. "Dioxygen-Copper Reactivity: Reversible Binding of Dioxygen and the Reactivity of Peroxo- and Hydroperoxo-Dicopper(II) Complexes" Rec. Trav. Chim. Pays-Bas 1987, 106(6-7), 368. 58. Garcia, M. C.; Karlin, K. D.; Holwerda, R. A. "Oxidation of (Hydroxyethyl)ferrocene by [2-pyridylmethylbis(2-ethylthioethyl)amine]copper(II)" J. Inorg. Biochem. 1987, 30, 167-175. 57. Karlin, K. D.; Cruse, R. W.; Gultneh, Y.; Farooq, A.; Hayes, J. C.; Zubieta, J. "Dioxygen-Copper Reactivity. Reversible Binding of O2 and CO to a Phenoxo-Bridged Dicopper(I) Complex" J. Am. Chem. Soc. 1987, 109, 2668-2679. 56. Pate, J. E.; Cruse, R. W.; Karlin, K. D.; Solomon, E. I. "Vibrational, Electronic and Resonance Raman Spectral Studies of [Cu2(XYL-O-)O2]+, a Copper(II) Peroxide Model Complex of Oxyhemocyanin" J. Am. Chem. Soc. 1987, 109, 2624-2630. 55. Karlin, K. D.; Cruse, R. W.; Gultneh, Y. "Dioxygen-Copper Reactivity: Preparation and Characterization of a Hydroperoxo-Dicopper(II) Complex" J. Chem. Soc. Chem.Commun. 1987, 596-600. 54. Karlin, K. D.; Farooq, A.; Hayes, J. C.; Cohen, B. I.; Rowe, T. M., Sinn, E., Zubieta, J. "Models for Met-Hemocyanin Derivatives: Structural and Spectroscopic Comparisons of Analogous Phenoxo- and X- (OH-, OMe-, N3-, Cl-, Br-, OAc-, OBz-) Doubly-Bridged Dinuclear Copper(II) Complexes" Inorg. Chem. 1987, 26, 1271-1280. 53. Karlin, K. D.; Cohen, B. I.; Hayes, J. C.; Farooq, A.; Zubieta, J. "Models for Met-Hemocyanin Derivatives: Structural and Spectroscopic Comparisons of Related Azido-Coordinated (N3-) Mono- and Dinuclear Copper(II) Complexes" Inorg. Chem. 1987, 26, 147-153. 52. Blackburn, N. J.; Strange, R. W.; Cruse, R. W.; Karlin, K. D. "Dioxygen-Copper Reactivity - EXAFS Studies of a Peroxo-Dicopper(II) Complex" J. Am. Chem. Soc. 1987, 109, 1235-1237. 51. Karlin, K. D.; Cruse, R. W.; Haka, M. S.; Gultneh, Y.; Cohen, B. I. "Intermediacy of a Peroxo-dicopper(II) Species in a Model Copper Mono-oxygenase System" Inorg. Chim. Acta 1986, 125, L43-L44. 50. Baek, H. K.; Karlin, K. D.; Holweda, R. A. "Kinetic Stability of the Cysteine Adduct with [Tris(2-pyridylethyl)amine]copper(II)" Inorg. Chem. 1986, 25, 2347-2349. 49. Karlin, K. D.; Cruse, R. W.; Gultneh, Y.; Hayes, J. C.; McKown, J. W.; Zubieta, J. "The Reversible Binding and Activation of Dioxygen with Dinuclear Copper Complex Systems" In Biological & Inorganic Copper Chemistry; Karlin, K. D.; Zubieta, J., Eds.; Adenine: Guilderland, N. Y., 1986; Vol. 2, pp 101-114. 48. Karlin, K. D.; Gultneh, Y.; Cruse, R.W.; Hayes, J. C.; Haka, M. S.; Zubieta, J. "Dioxygen Binding and Activation in Dinuclear Copper Complex Systems" In Frontiers in Bioinorganic Chemistry; Xavier, A., Ed.; VCH Publishers: Weinheim, Germany, 1986; pp 204-212. 47. Karlin, K. D.; Gultneh, Y. "Bioinorganic Chemical Modeling of Dioxygen-Activating Copper Proteins" J. Chem. Educ. 1985, 62 (11), 983-990. 46. Karlin, K. D.; Gultneh, Y.; Nicholson, T.; Zubieta, J. "Catecholate Coordination to Copper: Structural Characterization of a Tetrachloro-o-catecholate-Bridged Dicopper(II) Complex as a Model for Intermediates in Copper-Catalyzed Oxidation of Catechols" Inorg. Chem. 1985, 24, 3725-3727. 45. Karlin, K. D.; Haka, M. S.; Cruse, R.W.; Gultneh, Y. "Dioxygen-Copper Reactivity. Reversible O2 and CO Binding by a New Series of Binuclear Copper(I) Complexes" J. Am. Chem. Soc. 1985, 107, 5828-5829. 44. Karlin, K. D.; Cohen, B. I. "Synthesis and Characterization of Copper(II) Complexes of a Tetradentate N3O Ligand: Mononuclear Analogs for Phenolate-Bridged Dinuclear Complexes" Inorg. Chim. Acta 1985, 107, L17-L20. 43. Karlin, K. D.; Gultneh, Y.; Cruse, R. W.; Hayes, J. C.; Zubieta, J. "Dioxygen Binding and Activation in Dinuclear Copper Complex Systems" Rev. Port. Quim. 1985, 27, 20-21 (Abstracts of Lectures at 2nd Intl. Conf. Bioinorg. Chem., April 15-19, 1985, Algarve Portugal). 42. Pyrz, J. W.; Karlin, K. D.; Sorrell, T. N.; Vogel, G. C.; Que, L, Jr. "Resonance Raman Studies of Phenolate Bridged Binuclear Copper Complexes. Relevance to Hemocyanin and Tyrosinase" Inorg. Chem. 1984, 23, 4581-4584. 41. Karlin, K. D.; Cruse, R. W.; McKown, J. W.; Hayes, J. C.; Dahlstrom, P. L.; Zubieta, J. "Structure and Properties of a Monmeric Copper(II) Complex with a N3 Tridentate Unit Containing 2-Thio-1-Methylimidazole" Trans. Met. Chem. 1984, 9, 404-405. 40. Karlin, K. D.; McKown, J. W.; Hayes, J. C.; Hutchinson, J. P.; Zubieta, J. "Synthesis and Structure of a Mono-Chloro Bridged Copper(II) Dimer Containing a Linear Cu(II)-Cl-Cu(II) Bridge" Trans. Met. Chem. 1984, 9, 405-406. 39. Kokoszka, G.; Karlin, K. D.; Padula, F.; Baranowski, J.; Goldstein, C. "EPR of Cu(II) Complexes with Tripodal Ligands: Dynamical Properties" Inorg. Chem. 1984, 23, 4378-4380. 38. Blackburn, N. J.; Karlin, K. D.; Concannon, M.; Hayes, J. C.; Gultneh, Y.; Zubieta, J. "Studies on a Model Copper Monooxygenase System: Peroxo-Cu(II) Binuclear Intermediates in the Hydroxylation of an Aromatic Ring" J. Chem. Soc. Chem. Commun. 1984, 939-940. 37. Karlin, K. D.; Cruse, R. W.; Gultneh, Y.; Hayes, J. C.; Zubieta, J. "Peroxide Coordination to a Dicopper(II) Center. Dioxygen Binding to a Structurally Characterized Phenoxide Bridged Binuclear Copper(I) Complex" J. Am. Chem. Soc. 1984, 106, 3372-3374. 36. Karlin, K. D.; Yandell, J. K. "Redox Behavior of Blue Copper Model Complexes. Redox Potentials and Electron-Transfer Kinetics of Some Copper(II)-Copper(I) Complexes with Nitrogen and Thioether Donors" Inorg. Chem. 1984, 23, 1184-1188. 35. Karlin, K. D.; Gultneh, Y.; Hayes, J. C.; Zubieta, J. "Copper(I) Dioxygen Reactivity, 2. Reaction of a Three-coordinate Cu(I) Complex with O2 with Evidence for a Binuclear Oxo-Cu(II) Species: Structural Characterization of a Parallel-Planar Di-Hydroxo Bridged Dimer" Inorg. Chem. 1984, 23, 519-521. 34. Karlin, K. D.; Hayes, J. C.; Gultneh, Y.; Cruse, R. W.; McKown, J. W.; Hutchinson, J. P.; Zubieta, J. "Copper Mediated Hydroxylation of an Arene: Model System for the Action of Copper Monooxygenases and the Structures of a Binuclear Cu(I) Complex and its Oxygenated Product" J. Am. Chem. Soc. 1984, 106, 2121-2128. 33. Karlin, K. D.; Shi, J.; Hayes, J. C.; McKown, J. W.; Hutchinson, J. P.; Zubieta, J. "Cu(I)-Dioxygen Reactivity: Structural Characterization of a Bridged-Binuclear Cu(II) Complex Formed by Oxidation of a New Binuclear Cu(I) Compound" Inorg. Chim. Acta 1984, 91, L3-L7. 32. Karlin, K. D.; Hayes, J. C.; Hutchinson, J. P.; Zubieta, J. "Model Complexes for Ligand Probes of Met-Hemocyanin and Met-tyrosinase Derivatives. Structure of a Novel 1,1-Azido Bridged Binuclear Copper(II) Complex" J. Chem. Soc. Chem. Commun. 1983, 376-8. 31. Karlin, K. D.; Hayes, J.C.; Cruse, R. W.; Gultneh, Y.; Hutchinson, J. P.; Zubieta, J. "Model Complexes for the Active Sites of Reduced and Oxidized Sites of Hemocyanin and Tyrosinase. Structures of Binuclear Cu(I) and Cu(II) Complexes and Characterization of a Model Copper Monooxygenase Reaction" Inorg. Chim. Acta 1983, 79(B7), 98-99 (Intl. Conf. Bioinorg. Chem., Florence, Italy, June 1983). 30. Padula, F.; Goldstein, C.; Orsini, J.; Kokoszka, G.; Karlin, K. D. "EPR of Trigonal Bipyramidal Copper(II) Complexes with Tripod Ligands" Inorg. Chim. Acta 1983, 79(B7), 198-199. 29. Karlin, K. D.; Hayes, J. C.; Zubieta, J. "Copper(I) and Copper(II) Complexes with Xylyl Binucleating Ligands: Structures and Reactions with Dioxygen" In Copper Coordination Chemistry: Biochemical and Inorganic Perspectives; Karlin, K. D.; Zubieta, J., Eds.; Adenine Press: Albany, N.Y., 1983; pp 457-472. 28. Zubieta, J.; Karlin, K. D.; Hayes, J. C. "Structural Systematics of Cu(I) and Cu(II) Derivatives of Tripodal Ligands' In Copper Coordination Chemistry: Biochemical and Inorganic Perspectives; Karlin, K. D.; Zubieta, J., Eds.; Adenine Press: Albany, N.Y., 1983; pp 97-108. 27. Karlin, K. D.; Hayes, J. C.; Hutchinson, J. P.; Zubieta, J. "Synthesis and Characterization of a Novel Dicopper(I) Complex of a Thiaether Containing meta-Xylyl Binucleating Ligand" Inorg. Chim. Acta 1983, 78, L45-L46. 26. Karlin, K. D.; Gultneh, Y.; Hutchinson, J. P.; Zubieta, J. "Three-Coordinate Binuclear Copper(I) Complex: Model Compound for the Copper Sites in Deoxyhemocyanin and Deoxytyrosinase" J. Am. Chem. Soc. 1982, 104, 5240-5242. 25. Karlin, K. D.; Hayes, J. C.; Shi Juen; Hutchinson, J. P.; Zubieta, J. "Tetragonal vs. Trigonal Coordination in Copper(II) Complexes with Tripod Ligands: Structures and Properties of (Cu(C21H24N4)Cl)PF6 and (Cu(C18H18H4)Cl)PF6" Inorg. Chem. 1982, 21, 4106-4108. 24. Karlin, K. D.; Sherman, S. E. "Redox Comparisons of Pseudotetrahedral Copper(I) Complexes Containing Tripod Ligands" Inorg. Chim. Acta 1982, 65, L39-L40. 23. Karlin, K. D.; Moisan, M. P.; Kustyn, M.; Dahlstrom, P. L.; Zubieta, J.; Raithby, P. R. "Crystal and Molecular Structure of (Dicarbonyl(Triphenylphosphine)(Cyclooctatetraene)) Iron ((CO)2P(C6H5)3(C8H8)Fe)" Cryst. Struct. Commun. 1982, 11, 1945-1949. 22. Karlin, K. D.; Dahlstrom, P. L.; Hayes, J. C.; Simon, R. A.; Zubieta, J. "Crystal and Molecular Stucture of Nitrato (Tris(2(-Pyridyl)ethyl)amine) Copper(II) Nitrate, C21H24N4Cu(NO3)2, (Cu(tepa)NO3)NO3" Cryst. Struct. Commun. 1982, 11, 907-912. 21. Karlin, K. D.; Hayes, J. C.; Hutchinson, J. P.; Hyde, J. R.; Zubieta, J. "Synthesis and X-ray Structural Characterization of Cu(I) and Cu(II) Derivatives of a New Symmetrical Tripodal Ligand N(CH2CH2-py)3, (py=2-pyridyl)" Inorg. Chim. Acta 1982, 64, L219-L220. 20. Rosenstein, R. D.; Oberding, M.; Hyde, J. R.; Zubieta, J.; Karlin, K. D.; Seeman, N. C. "The Crystal Structure of Hypoxanthinium Nitrate Monohydrate, C5H7N5O5" Cryst. Struct. Commun. 1982, 11, 1507-1513. 19. Karlin, K. D.; Cruse, R. W.; Kokoszka, B. F.; Orsini, J. J. "ESR Spectra of a New Dicopper(II) Complexes of Novel Binucleating Ligands" Inorg. Chim. Acta 1982, 66, L57-L58. 18. Karlin, K. D.; Hyde, J. R.; Zubieta, J. "Synthesis and Structure of a Novel Dicopper(I) Complex of a New Binucleating Ligand" Inorg. Chim. Acta 1982, 66, L23. 17. Karlin, K. D.; Hyde, J. R.; Zubieta, J. "The Structure of the Copper(II) Analogue of a Pseudotetrahedral Copper(I) Thioether Complex" Trans. Metal. Chem. 1981, 6, 314. 16. Karlin, K. D.; Dahlstrom, P. L.; Cozzette, S. N.; Scensny, P. M.; Zubieta, J. "Activation of O2 by a Binuclear Copper(I) Compound. Hydroxylation of a New Xylyl-binucleating Ligand to Produce a Phenoxy-bridged Binuclear Copper(II) complex; X-ray Structure of (Cu2(OC6H3)(CH2-N(CH2CH2py)2))2-2,6)(OMe)) (py=2-pyridyl)" J. Chem. Soc. Chem. Commun. 1981, 881. 15. Augustin, M. A.; Yandell, J. K.; Addison, A.W.; Karlin, K. D. "Rates of Electron Transfer and Redox Potentials of some Copper(II) Thioether Complexes" Inorg. Chim. Acta 1981, 55, L35. 14. Karlin, K.D.; Dahlstrom, P. L.; DiPierro, L. T.; Simon, R. A.; Zubieta, J. "X-ray Structure Analysis of a Dicopper Complex of a New Binucleating Ligand Containing a para-Xylyl connecting Group; Large Cu...Cu Separation in ((CuCl2C18H30N3)2).2H2O" J. Coord. Chem. 1981, 11, 61. 13. Karlin, K. D.; Dahlstrom, P. L.; Hyde, J. R.; Zubieta, J. "Structural Comparison of Cu(I) and Cu(II) Complexes Displaying Analogous N2S2 Coordination: X-ray Analysis of (Cu(pma))BPh4 and (Cu(pma)SO4), pma= 2-(2-pyridyl)methyl)-bis(2-ethylthio)-ethyl)amine" J. Chem. Soc. Chem. Commun. 1980, 906-908. 12. Baltusis, L. M.; Karlin, K. D.; Rabinowitz, H. N.; Dewan, J. C.; Lippard, S. J. "Synthesis and Structure of Fe(L'H)(NO)2, a Tetracoordinate Complex Having a Twelve-Membered Chelate Ring, and its Conversion to Pentacoordinate FeL'(NO) Through Formal Loss of "HNO", L= -SCH2CH2NMeCH2CH2CH2NMeCH2CH2S-" Inorg. Chem. 1980, 19, 2627-2632. 11. Karlin, K. D.; Zubieta, J. "Coordination Chemistry of Copper-Sulfur Complexes of Physiological Relevance" Inorg. Persp. Biol. Med. 1979, 2, 127-149. 10. Karlin, K. D.; Dahlstrom, P. L.; Stanford, M. L.; Zubieta, J. "Distorted Tetrahedral Complexes of Copper(I) and Copper(II) Displaying N2S2 Coordination. X-Ray Crystal Structure of (2-(2-pyridyl)ethyl)bis(2-(ethylthio)ethyl)-amine Copper(I) Tetraphenylborate" J. Chem. Soc. Chem. Commun. 1979, 465-466. 9. Johnson, B. F. G.; Karlin, K. D.; Lewis, J.; Parker, D. G. "Reactions of Coordinated Ligands; Nucleophillic Addition of Halide Anions to Cyclohexadienylium(tricarbonyl)iron Cation" J. Organometal. Chem. 1978, 157, C67. 8. Karlin, K. D.; Johnson, B. F. G.; Lewis, J. "Aluminum Trihalide Promoted Carbonylation Reactions: Facile Synthesis of Bicyclo(3.2.1)oct-2-ene-4,8-dione from Cyclohexadiene(tricarbonyl)iron" J. Organometal. Chem. 1978, 145, C23. 7. Karlin, K. D.; Johnson, B. F. G.; Lewis, J. "Aluminum Trihalide Interactions with Polyolefin Tricarbonyl Iron Compounds" J. Organometal. Chem. 1978, 160, C21. 6. Charles, A. D.; Divirsi, P.; Johnson, B. F. G.; Karlin, K. D.; Lewis, J.; Rivera, A. V.; Sheldrick, G. M. "Tricarbonyl-(8-acetyl 2-4: 6-7-h-bicyclo-(3.2.1)cyclooctadienylium) Iron- A Novel Rearrangement from the Acylation of h-C8H8Fe(CO)3" J. Organometal. Chem. 1977, 128, C31. 5. Karlin, K. D.; Rabinowitz, H. N.; Lewis, D. L.; Lippard, S. J. "Synthesis, and Characterization of the Pentacoordinate Mononitrosyl Iron Complexes Fe(NO)(SCH2CH2N(CH3)(CH2)n-N(CH3)CH2CH2S), n=2,3" Inorg. Chem. 1977, 16, 3262. 4. Rabinowitz, H. N.; Karlin, K. D.; Lippard, S. J. "Oxidative Addition of Nitrosonium Ion to Sulfur-Bridged Binuclear Iron(II) and Cobalt(II) Complexes" J. Am. Chem. Soc. 1977, 99, 1420. 3. Ginsberg, A. P.; Lines, M. E.; Karlin, K. D.; Lippard, S. J.; DiSalvo, F. J. "Orbitally Dependent Exchange in Two Sulfur-Bridged Binuclear Iron(II) Complexes: Magnetic Exchanges in Transition Metal Complexes XI" J. Am. Chem. Soc. 1976, 98, 6958. 2. Karlin, K. D.; Lippard, S. J. "Sulfur-Bridged Binuclear Iron(II) Complexes: Effect of Ligand Constraints on their Physical Properties and Reactions with Carbon Monoxide and Alkyl Isocyanides" J. Am. Chem. Soc. 1976, 98, 6951. 1. Karlin, K. D.; Lewis, D. L.; Rabinowitz, H. N.; Lippard, S. J. "Addition of Nitrosonium Ion to Mercaptide-Bridged Binuclear Iron(II) and Cobalt(II) Complexes" J. Am. Chem. Soc. 1974, 96, 6519.