TAMARA L. HENDRICKSON
Assistant Professor of Chemistry
Assistant Professor of Biology
Member, Program in Molecular and Computational Biophysics

Remsen Hall
Department of Chemistry
Johns Hopkins University
3400 N. Charles Street
Baltimore, MD 21218

Phone: (410) 516-6706
Fax: (410) 516-8420
Email: Tamara.Hendrickson@jhu.edu

JHU Faculty Page

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EDUCATION

1990                     B.A.                                      Wellesley College

1996                     Ph.D.                                    California Institute of Technology

PROFESSIONAL APPOINTMENTS

1996-1997           NIH Postdoctoral Fellow           Massachusetts Institute of Technology

1997-2000           NIH Postdoctoral Fellow           Scripps Research Institute

AWARDS AND HONORS

2000 Research Corporation Innovation Award

PUBLICATIONS

Hendrickson Group Publications

Lee, J. H. and Hendrickson, T. L. "Divergent anticodon recognation in contrasting glutamyl-tRNA synthetases," J. Mol. Biol., 2004, in press.

Skouloubris, S.; Ribas de Pouplana, L.; de Reuse, H.; Labigne, A.; Hendrickson, T. L. "A new aminoacyl-tRNA synthetase that may resolve a missing link in protein evolution," Proc. Natl. Acad. Sci. USA, 2003, 100, 11297-11302. PNAS • PubMed

Hendrickson Group Reviews, Commentaries and other Publications

Hendrickson, T. L.; de Crecy-Lagard, V.; Schimmel, P. "Incorporation of non-natural amino acids into proteins," Invited book chapter, Ann. Rev. Biochem.,  2004, 73, 147-176. ARB • PubMed

Hendrickson, T. L.; Schimmel, P.; "Transfer RNA-dependent editing by aminoacyl-tRNA synthetases," Invited book chapter, Translation Mechanisms, Kluwer Academic Press, Jacques Lapointe, Ed., 2003, 34-64.

Hendrickson, T. L. "Yielding at Stop Codons: Expanding the Genetic Code," Chem. Biol. 2003, 10, 475-476.C&B • Pubmed

Hendrickson, T. L. "Recognizing the D-Loop of transfer RNAs," Proc. Natl. Acad. Sci, USA, 2001, 98, 13473-13475. PNAS • Pubmed

T. L. H. Postdoctoral and Thesis Work

Pathak, R.; Hendrickson, T. L.; Imperiali, B. "Sulfhydryl modification of the yeast Wbp1p inhibits Oligosaccharyl Transferase Activity," Biochemistry, 1995, 34, 4179-4185. Biochem • PubMed

Hendrickson, T. L.; Imperiali, B. "Metal ion dependence of Oligosaccharyl Transferase: Implications for catalysis," Biochemistry, 1995, 34, 9444-9450. Biochem • PubMed

Imperiali, B.; Hendrickson, T. L. "Asparagine-linked glycosylation: Specificity and function of oligosaccharyl transferase," Bioorg. Med. Chem., 1995, 3, 1565-1578. BMC • PubMed

Hendrickson, T. L.; Spencer, J. R.; Kato, M.; Imperiali, B. "Design and evaluation of potent inhibitors of asparagine-linked protein glycosylation," J. Am. Chem. Soc., 1996, 118, 7636-7637. JACS

Kellenberger, C.; Hendrickson, T. L.; Imperiali, B. "Structural and functional analysis of peptidyl oligosaccharyl transferase inhibitors," Biochemistry, 1997, 36, 12554-12559. Biochem • PubMed

Nureki, O.; Vassylyev, D. G.; Tateno, M.; Shimada, A.; Nakama, T.; Fukai, S.; Konno, M.; Hendrickson, T. L.; Schimmel, P.; Yokoyama, S. "Enzyme structure with two catalytic sites for double-sieve selection of substrate," Science, 1998, 280, 578-582. Science • PubMed

Imperiali, B.; O'Connor, S. E.; Hendrickson, T. L.; Kellenberger, C. "Chemistry and biology of asparagine-linked glycosylation," Pure and Applied Chem. 1999, 71, 777-789. PAC

Nomanbhoy, T. K.; Hendrickson, T. L., Schimmel, P. "Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis," Mol. Cell, 1999, 4, 519-528. MolCell • PubMed

Nureki, O.; Vassylyev, D. G.; Tateno, M.; Shimada, A.; Nakama, T.; Fukai, S.; Konno, M.; Hendrickson, T. L.; Schimmel, P.; Yokoyama, S. "Proofreading by isoleucyl-tRNA synthetase: Response," Technical comment in Science, 1999,283. 459. Science

Hendrickson, T. L.; Nomanbhoy, T. K.; Schimmel, P., "Errors from selective disruption of the editing center in a tRNA synthetase," Biochemistry, 2000,39, 8180-8186. Biochem • PubMed

Doring, V.; Mootz, H.; Nangle, L. A.; Hendrickson, T. L.; de Crecy-Lagard, V.; Schimmel, P.; Marliere, P. "Enlarging the amino acid set of Escherichia coli by infiltration of the valine-coding pathway," Science, 2001, 292, 501-504. Science • PubMed

*Commentaries on the above publication appeared in Science, Chemistry and Engineering News, Current Biology, the New York Times, and on National Public Radio.

Hendrickson, T. L.; Nomanbhoy, T. K.; de Crecy-Lagard, V.; Schimmel, P. "Mutational separation of two pathways for editing by a class I tRNA synthetase," Mol. Cell, 2002, 9, 353-362. MolCell • PubMed

Pezo V.; Metzgar D.; Hendrickson T.L.; Waas, W.F.; Hazebrouck, S.; Doring, V.; Marliere, P.; Schimmel, P.; De Crecy-Lagard, V. "Artificially ambiguous genetic code confers growth yield advantage," Proc. Natl. Acad. Sci. U S A, 2004, 101, 8593-7. PNAS • PubMed