Dr. Zhe Jin

Faculty Research Associate
Division of Gastroenterology
Department of Medicine
The Johns Hopkins University School of Medicine

1503 E. Jefferson St, Rm 143
Tel :(410) 502-6057
Fax: (410) 502-1329
Email: zjin1@jhmi.edu

M.D. 1992, China Medical University, CHINA
Ph.D. 2002, Yamagata University School of Medicine, JAPAN
 

Research Interest:

Epigentic alteration of cancer.

Methylation biomarkers for early detection of cancer.

Esophageal, gastric and breast cancer.

Selected Publication:

1. Jin Z: Analysis of clinical treatment of last stage of breast cancer (Chinese). Medical Journal of Liaoning 11: 155, 1997.

2. Jin Z, Ogata S, Kato N, Zhao S, Fukase M, Shibuya H, Okazaki E, Motoyama T: A comparative study of myxoid leiomyosarcoma of the uterus and leiomyoma with myxoid change (Japanese). Pathol Clin Med 18: 155‑160, 2000.

3. Jin Z, Tamura G, Satoh M, Meguro T, Miura T, Hayashi M, Osakabe M, Ohmura K, Ogarta S, Endoh Y, Motoyama T: Absence of BAT‑26 instability in gastric intestinal metaplasia. Pathol Int 51: 473‑475, 2001.

4. Jin Z, Tamura G, Tsuchiya T, Sakata K, Kashiwaba M, Osakabe M, Motoyama T. Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. Br J Cancer 85: 69‑73, 2001.

5. Jin Z, Tamura G, Honda T, Motoyama T: Molecular and Cellular Phenotypic Profiles of Gastric Non‑invasive Neoplasia. Lab Invest, 82: 1637‑1645, 2002.

6. Jin Z, Ogata S, Tamura G, Katayama Y, Fukase M, Yajima M, Motoyama T: Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis. Int J Gynecol Pathol, 22: 368‑373, 2003.

7. Jin Z, Mori Y, Yang J, Sato F, Ito T, Cheng Y, Paun B, Hamilton JP, Kan T, Olaru A, David S, Agarwal R, Abraham JM, Beer D, Montgomery E, Meltzer SJ. Hypermethylation of the nel-like 1 gene is a common and early event and is associated with a poor prognosis in early-stage esophageal adenocarcinoma. Oncogene 2007 Sep 20;26(43):6332-40.

8. Jin Z, Olaru A, Yang J, Sato F, Cheng Y, Mori Y, Mantzur C, Paun B, Hamilton JP, Ito T, Kan T, Wang S, David S, Agarwal R, Beer DG, Abraham JM, Meltzer SJ. Hypermethylation of Tachykinin-1 is Associated with a Poor Prognosis in Human Esophageal Squamous Cell Carcinoma. Clin. Cancer Res. 2007 Nov 1;13(21):6293-6300.

9. Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Paun B, Kan T, Agarwal R, Meltzer SJ. Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis. Cancer 2008 Jan 1;112(1):43-49.

10. Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Agarwal R, Abraham JM, Meltzer SJ. Hypermethylation of the AKAP12 Promoter is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression. Cancer Epidemiology, Biomarkers & Prevention 2008 Jan; 17(1):1-16.

11. Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Agarwal R, Abraham JM, Meltzer SJ. Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. Int. J. Cancer 2008 Nov 15;123(10):2331-2336.

12. Jin Z, Cheng Y, Zheng Y, Gu J, Sato F, Olaru AV, Paun B, Yang J, Kan T, Ito T, Hamilton JP, Selaru FM, Mori Y, Agarwal R, David S, Abraham JM, Wolfsen H, Shaheen NJ, Wang J, Canto M, Washington K, Romero Y, Wang KK, Feng Z, Sampliner RD, Meltzer SJ. A multi-center, double-blinded validation study of methylation biomarkers for progression prediction in Barrett’s esophagus. Cancer Res. 2009, in press.
 

                                                Last modified 05/12/2009