Dr. Yulan Cheng

     Lab Manager
    Division of Gastroenterology
    Department of Medicine
    The Johns Hopkins University School of Medicine

    1503 E. Jefferson St, Rm 106
    Tel :(410) 502-6057
    Fax: (410) 502-1329
    Email: ycheng20@jhmi.edu

    M.D., 1986, Shanxi Medical University, CHINA

    I enjoy interacting with people and helping others. As the lab manager, I also spend a lot of time making sure that everything runs smoothly in the lab so that we have the necessary tools to conduct research. During my 8 years in GI research, I have been involved in many projects, which include: molecular and cellular mechanisms underlying gastritis; colitis; esophageal, gastric and colorectal carcinogenesis. Currently, I am involved in two projects: methylation biomarkers for early detection of cancer and novel tumor suppressor genes functional study.
 

Selected Publications:

1.     Jin Z, Cheng Y, Olaru A, Kan T, Paun B, Ito T, Hamilton JP, David S, Agarwal R, Selaru FM, Sato F, Abraham JM, Beer DG, Mori Y, Shimada Y, Meltzer SJ. Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. Int J Cancer. 2008 Nov 15;123(10):2331-6.

2.     Abraham JM, Cheng Y, Hamilton JP, Paun B, Jin Z, Agarwal R, Kan T, David S, Olaru A ,Yang J, Ito T, Selaru FM, Mori Y, Meltzer SJ. Generation of small 32P-labeled peptides as a potential approach to colorectal cancer therapy. PLoS ONE. 2008 Jun 25;3(6):e2508.

3.     Ito T, Shimada Y, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru A, Hamilton JP, Yang J, Abraham JM, Meltzer SJ, Sato F. Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. Cancer Res. 2008 May 1;68(9):3214-24.

4.     John M. Abraham,^1* Fumiaki Sato,¹ Yulan Cheng,¹ Bogdan Paun,¹ Takatsugu Kan,¹ Alexandru Olaru,¹ Zhe Jin,¹ Jian Yang,¹ Rachana Agarwal,¹ Stefan David,¹James P. Hamilton,¹ Tetsuo Ito,¹ Yuriko Mori,¹ and Stephen J. Meltzer^1,2 Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. PLoS ONE. 2007 Oct 3;2(10):e964.

5.     Mori Y, Cai Y, Cheng Y, Wang S, Paun B, Hamilton JP, Jin Z, Sato F, Berki AT, Kan T, Ito T, Abraham JM, Meltzer SJ. A genome-wide search isolate somatostatin, tachykinin-1, and five other genes as targets of epigenetic silencing in human colon cancer. Gastroenterology. 2006 Sep;131(3):797-808.

6.     Sato F, Abraham JM, Yin J, Kan T, Ito T, Mori Y, Hamilton JP, Jin Z, Cheng Y, Paun B, Berki AT, Wang S, Shimada Y, Meltzer SJ. Polo-like kinase and survivin are esophageal tumor-specific promoters. Biochem Biophys Res Commun. 2006 Apr 7;342(2):465-71.

7.     Wang S, Zhan M, Yin J, Abraham1 JM, Mori1 Y, Sato1 F, Xu Y, Olaru1A, Berki1 AT, Li H, Schulmann1 K,  Kan T, Hamilton1 JP, Paun1 B, Yu MM, Jin Z, Cheng Y, Ito T, Mantzur C, Greenwald BD and Stephen J. Meltzer. Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis. Oncogene. 2006 Jan 30; [Epub ahead of print].

8.     Cheng Y, Chaturvedi R, Asim M, Bussiere FI, Xu H, Casero RA Jr, Wilson KT. Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. J Biol Chem. 2005 Jun 10;280(23):22492-6.

9.     Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Drachenberg CB, Chaturvedi R, Boucher JL, Hacker A, Casero RA, Jr., Wilson KT. Protective role of arginase in a mouse model of colitis. J. Immunol. 173:2109-2117, 2004.

10.  Chaturvedi R, Cheng Y, Asim M, Bussiere FI, Xu H, Gobert AP, Hacker A, Casero R.A., Jr., Wilson KT. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J. Biol. Chem., 279:40160-40173, 2004.

11.  Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA, Jr, Wilson KT. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: Implications for gastric carcinogenesis. Cancer Res., In press, 2004.

12.  Bussiere FI, Chaturvedi R, Cheng Y, Gobert AP, Asim M, Blumberg DR, Xu H, Kim P, Hacker A, Casero RA, Jr., Wilson KT. Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric oxide synthase. J. Biol. Chem., In press, 2004.

13.  Gobert AP, Cheng Y, Wang J-Y, Boucher J-L, Iyer RK, Cederbaum SD, Casero RA Jr., Newton JC, Wilson KT. H. pylori induces macrophage apoptosis by activation of arginase II. J. Immunol. 168:4692-4700, 2002.

14.  Gobert AP, Mersey BD, Cheng Y, Blumberg DR, Newton JC, Wilson KT. Cutting Edge: Activation of macrophage inducible nitric oxide synthase by Helicobacter pylori urease. J. Immunol. 168:6002-6006, 2002.

15.  Akhtar M, Cheng Y, Magno RM, Ashktorab H, Smoot DT, Meltzer SJ, Wilson    KT. Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. Cancer Res., 2001.61: 2399-2403.

16.  Gobert AP, McGee DJ, Akhtar M, Mendz GL, Newton JC, Cheng Y, Mobley HLT, Wilson KT. Helicobacter pylori arginase inhibits NO production by eukaryotic cells: a strategy for bacterial survival. Proc. Natl. Acad. Sci. USA, 98:13844-13849, 2001.

                                               Last modified 05/12/2009