|
 |
| |
An LOH and mutational analysis of the ACTRII gene locus in human
colorectal tumors. |
| Olaru
A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F,
Selaru FM, Deacu E, Shibata D, Abraham JM, Meltzer SJ. |
| Lab. Invest.
2003 Dec; 83(12):1867-1861. |
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The impact of microsatellite instability on the molecular
phenotype of colorectal tumors. |
| Mori Y,
Selaru F, Sato F, Xu Y, Wang S, Yin J, Abraham JM, Olaru A,
Deacu E, Kimos M, Perry K, Shibata D, Young J, Leggett B,
Meltzer SJ. |
| Cancer Res.
2003 Aug 1; 63(15):4577-4582. |
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An LOH and mutational investigation of the ST7 gene locus in
human esophageal carcinoma. |
| Wang S, Mori
Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos MC, Perry K,
Selaru FM, Deacu E, Sun M, Shi YC, Shibata D, Abraham JM,
Greenwald BD, Meltzer SJ. |
| Oncogene
2003 Jan 23; 22(3):467-470. |
|
Pharmacologic unmasking of epigenetically silenced tumor
suppressor genes in esophageal squamous cell carcinoma. |
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Yamashita K, Upadhyay S, Osada M, Hoque MO, Xiao Y, Mori M, Sato
F, Meltzer SJ, |
| Cancer Cell
2002, Dec; 2(12):485-495. |
|
Aberrant methylation of the HPP1 gene in ulcerative
colitis-associated colorectal carcinoma. |
| Sato F,
Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu
E, Selaru F, Kimos M, Hytiroglou P, Young J, Leggett B, Gazdar
AF, Toyooka S, Abraham JM, Meltzer SJ. |
|
Cancer Res. 2002 Dec 1; 62(23):6820-6822. |
|
Morphological and molecular heterogeneity
within non-microsatellite instability-high colorectal cancer.
|
| Whitehall VLJ,
Wynter CVA, Walsh MD, Simms LA, Purdie D, Pandeya N, Young J,
Meltzer SJ, Leggett BA, Jass JR. |
| Cancer Res.
2002 Nov 1; 62(21):6011-6014. |
|
Hypermethylation of HPP1 is associated with hMLH1
hypermethylation in gastric adenocarcinomas. |
| Shibata
DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A,
Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ. |
| Cancer Res.
2002 Oct 15; 62(20):5637-40. |
|
E2F-4 mutation in hereditary non-polyposis colorectal cancer. |
| Moriyama
H, Sasamoto H, Kambara T, Matsubara N, Ikeda M, Baba S, Meltzer
SJ, Lynch HT, Shimizu K, Tanaka N. |
|
J Exp Clin Cancer Res. 2002
Jun; 21(2):185-9. |
|
Instabilotyping reveals novel unique mutational spectra in
microsatellite-unstable gastric cancers. |
| Mori Y,
Selaru FM, Olaru A, Perry K, Kimos MC, Tamura G, Matsubara N,
Sato F, Wang S, Xu Y, Yin J, Zou T-T, Leggett B, Young J, Nukiwa
T, Stine OC, Abraham JM, Shibata D, Meltzer SJ. |
| Cancer Res.
2002; 62:3641-3645. |
|
Application of cDNA microarrays to generate a molecular taxonomy
capable of distinguishing between colon cancer and normal colon. |
| Zou T,
Selaru F, Xu Y, Yin J, Shustova V, Mori Y, Sato F, Liu TC,
Abraham JM, Meltzer SJ. |
| Oncogene
2002; 21:4855-4862. |
|
Artificial neural networks and gene filtering distinguish
between global gene expression profiles of Barrett’s esophagus
and esophageal cancer. |
| Xu Y,
Selaru FM, Yin J, Zou TT, Shustova V, Mori Y, Sato F, Liu TC,
Olaru A, Wang S, Kimos MC, Perry K, Desai K, Greenwald BD,
Krasna MJ, Shibata D, Abraham JM, Meltzer SJ. |
| Cancer Res.
2002; 62:3493-3497. |
|
Aberrant methylation of the CDH13 (H-cadherin) promoter region
in colorectal cancers and adenomas. |
| Toyooka
S, Toyooka KO, Harada K, Miyajima K, Makarla P, Sathyanarayan UG,
Yin J, Sato F, Shivapurkar N, Meltzer SJ, Gazdar AF. |
| Cancer Res. 2002;
62:3382-3386. |
|
Activation of the esophagin promoter during esophageal
epithelial cell differentiation. |
| Smolinski KN,
Abraham JM, Souza RF, Yin J, Wang S, Xu Y, Zou T-T, Kong D,
Fleisher AS, Meltzer SJ. |
| Genomics 2002;
79:875-880. |
|
Analysis of genetic and epigenetic alterations of the PTEN
gene in gastric cancer. |
| Sato K,
Tamura G, Tsuchiya T, Endoh Y, Sakata K, Motoyama T, Usuba O,
Kimura W, Terashima M, Nishizuka S, Zou T, Meltzer SJ. |
| Virchows
Arch. 2002; 440:160-165. |
|
Artificial
neural networks distinguish among subtypes of neoplastic
colorectal lesions. |
| Selaru F, Xu Y, Yin J, Zou T, Liu TC, Mori Y, Abraham JM, Sato F, Wang S,
Twigg C, Olaru A, Shustova V, Leytin A, Shibata D, Harpaz N,
Meltzer SJ. |
| Gastroenterol.
2002; 122:606-613. |
|
Hypermethylation of the p14ARF gene in ulcerative
colitis-associated colorectal carcinogenesis. |
| Sato F,
Harpaz N, Shibata D, Xu Y, Yin J, Mori Y, Zou T-T, Wang S, Desai
K, Leytin A, Selaru F, Abraham JM, Meltzer SJ. |
| Cancer Res.
2002; 62:1148-1151. |
|
Global gene expression profiling in Barrett’s esophagus and
esophageal cancer: a comparative analysis using cDNA microarrays. |
| Selaru F, Zou T, Shustova V, Xu Y, Yin J, Mori Y, Sato F, Wang S, Shibata
D, Greenwald BD, Krasna MJ, Abraham JM, Meltzer SJ. |
| Oncogene
2002; 21:475-478. |
|
Glypican-3 expression in Wilms tumor and hepatoblastoma. |
| Toretsky
JA, Zitomersky NL, Eskenazi AE, Voigt RW, Strauch ED, Sun CC,
Huber R, Meltzer SJ, Schlessinger D. |
| J. Ped.
Hematol./Oncol. 2001; 23:496-499. |
|
Proton pump inhibitors reduce cell cycle abnormalities in
Barrett’s esophagus. |
| Umansky
M, Yasui W, Hallak A, Brill S, Shapira I, Halpern Z, Nibshoosh
H, Rattan J, Meltzer S, Tahara E, Arber N. |
| Oncogene
2001; 20:7987-7991. |
|
Effect of naturally occurring E2F-4 alterations on
transcriptional activation and proliferation in transfected
cells. |
| Takashima
H, Matsumoto Y, Matsubara N, Shirakawa Y, Kawashima R, Tanino M,
Ito S, Isozaki H, Ouchida M, Meltzer SJ, Tanaka N, Shimizu K. |
| Lab Invest.
2001; 81:1565-1573. |
|
Activation of a cryptic splicing site of PTEN and allelic
imbalance in benign skin lesions in Cowden disease. |
| Trojan J, Plotz
G, Brieger A, Raedle J, Meltzer SJ, Wolter M, Zeuzem S. |
| J. Invest.
Dermatol. 2001; 117:1650-1653. |
|
Adenomatous Polyposis Coli gene promoter hypermethylation in
non-small cell lung cancer is associated with survival.
|
| Brabender
J, Usadel H, Danenberg KD, Metzger R, Schneider PM, Lord RV,
Wickramasinghe K, Lum CE, Park JM, Salonga D, Sidransky D,
Hölscher AH, Meltzer SJ, Danenberg PV. |
| Oncogene 2001;
20:3528-3532. |
|
Instabilotyping: comprehensive identification of novel
cancer-related genes by large-scale probing for mutations in
coding region microsatellites. |
| Mori Y, Yin J,
Rashid A, Leggett BA, Young J, Kuehl PM, Langenberg P, Meltzer
SJ,* Stine OC. |
| Cancer Res.
2001; 61:6046-6049. * = corresp. author |
|
p14 (ARF) silencing by promoter hypermethylation mediates
abnormal intracellular localization of MDM2. |
| Esteller M,
Cordon-Cardo C, Corn PG, Meltzer SJ, Pohar KS, Watkins NG,
Capella G, Peinado MA, Matias-Guiu X, Prat J, Baylin SB, Herman
JG. |
| Cancer Res. 2001;
61:2816-2821. |
|
Promoter methylation regulates Helicobacter pylori-stimulated
cyclooxygenase-2 expression in gastric epithelial cells.
|
| Akhtar M,
Cheng Y, Magno RM, Ashktorab H, Smoot DT, Meltzer SJ, Wilson KT. |
| Cancer Res.
2001; 61:2399-2403. |
|
Hypermethylation of the hMLH1 gene promoter is associated
with microsatellite instability in early human gastric neoplasia. |
| Fleisher
AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, Zou TT,
Abraham JM, Kong D, Nishizuka S, James SP, Wilson KT, Herman JG,
Meltzer SJ. |
| Oncogene
2001; 20:329-335. |
|
Hypermethylated APC promoter DNA in serum and prognosis in
esophageal adenocarcinoma patients. |
| Kawakami,
K., Brabender, J., Lord, R.V., Groshen, S., Greenwald, B.D.,
Krasna, M.J., Yin, J., Fleisher, A.S., Abraham, J.M., Beer, D.G.,
Sidransky, D., Huss, H.T., DeMeester, T.R., Eads, C.A., Laird,
P.W., Ilson, D.H., Kelsen, D.P., Harpole, D., Moore, M.-B.,
Danenberg, K.D., Danenberg, P.V., Meltzer S.J. |
| J. Natl. Cancer
Inst. 2000; 92:1805-1811. |
|
Microsatellite instability in IBD-associated neoplastic lesions
is associated with hypermethylation and diminished expression of
the DNA mismatch repair gene, hMLH1. |
| Fleisher
AS, Esteller M, Leytin A, Harpaz N, Rashid A, Xu Y, Liang J,
Stine OC, Yin J, Zou T-T, Abraham JM, Kong D, Wilson KT, James
SP, Herman JG, Meltzer SJ. |
| Cancer Res.
2000; 60:4864-4868. |
|
Analysis
of Adenomatous Polyposis Coli promoter hypermethylation in human
cancer. |
| Esteller,
M, Sparks, A, Toyota, M, Sanchez-Cespedes, M, Capella, G,
Peinado, MA, Gonzalez, S, Tarafa, G, Sidransky, D, Meltzer, SJ,
Baylin, SB, Herman, JG. |
| Cancer Res.
2000; 60:4366-4371. |
|
Distinct
methylation patterns of two APC gene promoters in normal and
cancerous gastric epithelium. |
| Tsuchiya T,
Tamura G, Sato K, Endoh Y, Sakata K, Jin Z, Motoyama T, Usuba O,
Kimura W, Nishizuka S, Yin J, Fleisher AS, Zou T, Kong D,
Meltzer SJ. |
| Oncogene 2000; 19:3642-6. |
|
E-cadherin gene
promoter hypermethylation in primary gastric carcinomas. |
| Tamura G,
Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski
KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Motoyama T,
Meltzer SJ. |
| J.
Natl. Cancer Inst. 2000; 92:569-573. |
|
Colon polyps in
Beckwith-Wiedmann syndrome: role of imprinted genes. |
| Fleisher AS, Meltzer SJ, James SP |
| Gastroenterology 2000; 118:637. |
|
The apoptotic regulatory gene, BCL10, is mutated in sporadic
mismatch repair deficient colorectal cancers. |
|
Simms LA, Young J, Wicking C, Meltzer SJ, Jass JR, Leggett
BA.
|
|
Cell Death Diff. 2000; 7:236-237. |
|
PTEN1 is
frequently mutated in primary endometrial carcinomas. |
|
Kong D, Suzuki A, Zou TT, Sakurada A,
Kemp LW, Wakatsuki S, Yokoyama T, Yamakawa H, Furukawa T, Sato M,
Ohuchi N, Sato S, Yin J, Wang S, Abraham JM, Souza RF, Smolinski
KN, Meltzer SJ, Horii A. |
|
Nat Genet. 1997 Oct;17(2):143-4. |
|
Microsatellite instability in the insulin-like growth factor II
receptor gene in gastrointestinal tumours. |
|
Souza RF, Appel R, Yin J, Wang S, Smolinski
KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K,
Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N,
Sugimura H, Young J, Meltzer SJ. |
|
Nat
Genet. 1996 Nov;14(3):255-7. |
|
Esophagin cDNA cloning and characterization: a tissue-specific
member of the small proline-rich protein family that is not
expressed in esophageal tumors. |
|
Abraham JM, Wang S, Suzuki H, Jiang HY,
Rosenblum-Vos LS, Yin J, Meltzer SJ. |
|
Cell Growth Differ. 1996 Jul;7(7):855-60. |
|
p53 protein expression in ulcerative colitis-associated
colorectal dysplasia and carcinoma |
|
Harpaz N, Peck AL, Yin J, Fiel I,
Hontanosas M, Tong TR, Laurin JN, Abraham JM, Greenwald BD, Meltzer
SJ. |
|
Hum
Pathol. 1994 Oct;25(10):1069-74. |
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Microsatellite instability in ulcerative colitis-associated
colorectal dysplasias and cancers. |
| Suzuki H,
Harpaz N, Tarmin L, Yin J, Jiang HY, Bell JD, Hontanosas M,
Groisman GM, Abraham JM, Meltzer SJ. |
|
Cancer
Res. 1994 Sep 15;54(18):4841-4. |
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17p allelic
losses in diploid cells of patients with Barrett's esophagus who
develop aneuploidy. |
| Blount PL,
Galipeau PC, Sanchez CA, Neshat K, Levine DS, Yin J, Suzuki H,
Abraham JM, Meltzer SJ, Reid BJ. |
|
Cancer
Res. 1994 May 1;54(9):2292-5. |
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Microsatellite instability occurs frequently in human gastric
carcinoma. |
| Rhyu MG, Park
WS, Meltzer SJ. |
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Oncogene.
1994 Jan;9(1):29-32. |
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p53 point mutations in dysplastic and cancerous ulcerative
colitis lesions. |
| Yin J, Harpaz
N, Tong Y, Huang Y, Laurin J, Greenwald BD, Hontanosas M,
Newkirk C, Meltzer SJ. |
|
Gastroenterology. 1993 Jun;104(6):1633-9. |
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Clonal
ordering of 17p and 5q allelic losses in Barrett dysplasia and
adenocarcinoma. |
| Blount PL,
Meltzer SJ, Yin J, Huang Y, Krasna MJ, Reid BJ. |
|
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3221-5. |
|
Reduction to homozygosity involving p53 in esophageal cancers
demonstrated by the polymerase chain reaction. |
| Meltzer SJ,
Yin J, Huang Y, McDaniel TK, Newkirk C, Iseri O, Vogelstein B,
Resau JH. |
|
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4976-80. |
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Activation of c-Ki-ras in human gastrointestinal dysplasias
determined by direct sequencing of polymerase chain reaction
products. |
| Meltzer SJ,
Mane SM, Wood PK, Resau JH, Newkirk C, Terzakis JA, Korelitz BI,
Weinstein WM, Needleman SW. |
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Cancer
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