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For publications of before 2004.   
Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles.
     Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A.
     Clin Cancer Res. 2011 Oct 1;17(19):6239-6249. Epub 2011 Aug 15.
Germline mutations in MTB1, ANBC1 and CHDC1 in individuals with Barrett esophagus and/or esophageal adenocarcinoma.
     Orloff M, Peterson C, Ganapathi S, He X, Heald B, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ,* Eng C.
     JAMA 2011, in press. *Co-corresponding and co-senior author
Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers.
     Olaru AV, Cheng Y, Agarwal R, Yang J, David S, Abraham JM, Yu W, Lazarev M, Brant SR, Marohn MR, Hutcheon DF, Harpaz N, Meltzer SJ, Mori Y.
     Inflamm. Bowel Dis. 2011, in press.
Strong inhibition of xenografted tumor growth by low-level doses of [32P]ATP.
     Cheng Y, Yang J, Agarwal R, Green GM, Mease RC, Pomper MG, Meltzer SJ, Abraham JM.
     Oncotarget 2011 Jun 5 [Epub].
Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning.
     Mori Y, Olaru AV, Cheng Y, Agarwal R, Yang J, Luvsanjav D, Yu W, Lazarev M, Kwon JH, Brant SR, Hutcheon DF, Duncan MD, Goel A, Meltzer SJ.
     Endocr.-Related Cancer 2011 Jun 2 [Epub].
A DNA methylation blueprint of 1,628 human samples
     Fernandez AF, Assnov Y, Martin-Subero I, Balin B, Siebert R, Taniguchi H, Yamamoto H, Hidalgo M, Tan A-C, Galm O, Ferrer I, Sanchez-Cespedes M, Villaneuva A, Carmona J, Sanchez-Mut JV, Berdasco M, Moreno V, Capella G, Monk D, Ballestar E, Ropero S, Martinez R, Sanchez-Carbayo M, Prosper F, Agirre X, Fraga MF, Grana O, Perz-Jurado L, Mora J, Puig S, Prat J, Badimon L, Puca AA, Meltzer SJ, Lengauer T, Bridgewater J, Bock C, Esteller M.
     Genome Res. 2011 May 25 [Epub]
Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group.
    Yoon HH, Catalano PJ, Murphy KM, Skaar TC, Philips S, Powell M, Montgomery EA, Hafez MJ, Offer SM, Liu G, Meltzer SJ, Wu X, Forastiere AA, Benson AB, Kleinberg LR, Gibson MK.
     BMC Cancer 2011 May 17; 11(1):176 [Epub].
Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis.
    Alvarez H, Opalinska J, Zhou L, Sohal D, Fazzari M, Yu Y, Montagna C, Montgomery E, Canto M, Dunbar K, Wang J, Roa JC, Mo Y, Bhagat T, Ramesh KH, Cannizzaro L, Mollenhauer J, Thompson R, Suzuki M, Meltzer SJ, Melnick A, Greally J, Maitra A, Verma A.
    PLoS Genet 2011, 7(3): e1001356. doi:10.1371/journal.pgen.10
Dynamic changes in the expression of microRNA-31 during inflammatory bowel disease-associated neoplastic transformation.
    Olaru AV, Selaru F, Mori Y, Vazquez C, David S, Paun BC, Cheng Y, Jin Z, Yang, J, Agarwal R, Abraham JM, Dassopoulos T, Harpaz N, Bayless T, Kwon J, Livak F, Meltzer SJ.
    Inflammatory Bowel Diseases 2011 Jan;17(1):221-31; PMID: 20848542.
Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer.
    Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, Paun BC, Jin Z, Olaru AV, Hamilton JP, Selaru FM, Yang J, Matsumura N, Shimizu K, Abraham JM, Shimada Y, Mori Y, Meltzer SJ.
    Int. J. Cancer 2010 Dec 17. [Epub ahead of print] PMID: 21170987.
MicroRNAs -192 and -215 are upregulated in human gastric cancer and suppress ALCAM expression in vitro.
    Jin Z, Cheng Y, Kan T, Mori Y, Agarwal R, Olaru AV, Yang J, Hamilton JP, David S, Abraham JM, Montgomery EA, Meltzer SJ.
    Oncogene 2010 Nov 29 [Epub ahead of print] PMID: 21119604.
SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome.
    Kashyap MK, Harsha HC, Renuse S, Pawar H, Sahasrabuddhe NA, Kim M-S, Marimuthu A, Keerthikumar S, Muthusamy B, Kandasamy K, Subbannayya Y, Prasad TSK, Mahmood R, Chaerkady R, Meltzer SJ, Kumar RV, Rustgi AK, Pandey A.
    Cancer Biol. Ther. 2010 Oct 7;10(8). [Epub ahead of print] PMID: 20686364.
Identification of microRNAs associated with ileal and colonic Crohn's disease.
     Wu F, Zhang S, Dassopoulos T, Harris ML, Bayless TM, Meltzer SJ, Brant SR, Kwon JH.
     Inflammatory Bowel Diseases 2010 Oct;16(10):1729-38; PMID: 20848482.
Overexpression of periostin and lumican in esophageal squamous cell carcinoma
    Kashyap MK, Marimuthu A, Peri S, Ghantasala S, Kumar S, Jacob HKC, Prasad TSK, Mahmood R, Veerendra Kumar KV, Kumar M, Meltzer SJ, Montgomery EA, Kumar RV, Pandey A.
    Cancers 2010, 2(1), 133-142; doi:10.3390/cancers2010133 - published online 1 March 2010.
Relationship between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas
    Bogdan C. Paun, Debra Kukuruga, Zhe Jin, Yuriko Mori, Yulan Cheng, Mark Duncan, Sanford A. Stass, Elizabeth Montgomery, David Hutcheon and Stephen J. Meltzer
    Cancer. 2010 Oct 1;116(19):4495-501.
Silencing of Claudin-11 Is Associated with Increased Invasiveness of Gastric Cancer Cells
    Rachana Agarwal, Yuriko Mori, Yulan Cheng, Zhe Jin, Alexandru V. Olaru, James P. Hamilton, Stefan David, Florin M. Selaru, Jian Yang, John M. Abraha1, Elizabeth Montgomery,  Patrice J.Morin, Stephen J. Meltzer
    PLoS One. 2009 Nov;4(11):e8002.
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma
    Kan T, Stephen J. Meltzer.
    Current Opinion in Pharmacology Corresponding. 2009, 9:727–732
Screening for Microsatellite Instability Identifies Frequent 3'-Untranslated Region Mutation of the RB1-Inducible Coiled-Coil 1 Gene in Colon Tumors
    Bogdan C. Paun, Yulan Cheng, Barbara A. Leggett, Joanne Young, Stephen J. Meltzer, Yuriko Mori
    PLoS One. 2009 Nov 2;4(11):e7715.
Chromosomal abnormalities and novel disease-related regions in progression from Barrett’s esophagus to esophageal adenocarcinoma
    Akagi T, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G, Olaru A, Kawamata N, Boult J, Soukiasian J, Miller C, Ogawa S, Meltzer SJ, Koeffler HP
    International Journal of Cancer, 2009 Nov 15;125(10):2349-59.
A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett’s Esophagus
    Jin Z, Cheng Y, Zheng Y, Gu J, Sato F, Olaru AV, Paun B, Yang J, Kan T, Ito T, Hamilton JP, Selaru FM, Mori Y, Agarwal R, David S, Abraham JM, Wolfsen H, Shaheen NJ, Wang J, Canto M, Washington K, Romero Y, Wang KK, Feng Z, Sampliner RD, Meltzer SJ.
    Cancer Res. 2009, May 15; 69(10): 4112-4115.
The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM, Mori Y, Meltzer SJ.
    Gastroenterology. 2009 May;136(5):1689-700.
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.
    Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H, Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores GJ, LaRusso NF, Hruban R, Meltzer SJ.
     Hepatology. 2009 May;49(5):1595-601.
Generation of Small 32P-Labeled Peptides as a Potential Approach to Colorectal Cancer Therapy
    John M. Abraham, Yulan Cheng, James P. Hamilton, Bogdan Paun,  Zhe Jin, Rachana Agarwal, Takatsugu Kan, Stefan David, Alexandru Olaru, Jian Yang,   Tetsuo Ito, Florin M. Selaru, Yuriko Mori, Stephen J. Meltzer
    PLoS ONE. 2008 June; 3(6): e2508.
Three-tiered Risk Stratification Model to Predict Progression in Barrett’s Esophagus Using Epigenetic and Clinical Features
    Sato F, Jin Z, Schulmann K, Wang J, Greenwald B, Ito T, Kan T, Hamilton JP, Yang J, Paun B, David S, Olaru A, Cheng Y,  Mori Y, Abraham JM, Yfantis H, Wu T, Fredericksen M, Wang  K, Canto M, Romero Y, Feng Z, Meltzer SJ.
    PLoS ONE. 2008 Apr 2; 3(4):e1890.
PTTG1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma
    Ito T, Shimada Y, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru A, Hamilton JP, Yang J, Abraham JM, Meltzer SJ, Sato F
    Cancer Research. 2008 May 1;68(9):3214-3224
Hypermethylation of the AKAP12 Promoter is a Biomarker of Barrett's-Associated Esophageal Neoplastic Progression
    Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Agarwal R, Abraham JM, Meltzer SJ.
   Cancer Epidemiology Biomarkers & Prevention. 2008, Jan 1; 17 111-117.
Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis.
   Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Paun B, Kan T, Agarwal R, Meltzer SJ.
   Cancer. 2008 Jan 1;112(1):43-9.
Novel Decapeptides that Bind Avidly and Deliver Radioisotope to Colon Cancer Cells
 John M. Abraham, Fumiaki Sato, Yulan Cheng, Bogdan Paun, Takatsugu Kan, Alexandru Olaru, Zhe Jin, Jian Yang, Rachana Agarwal, Stefan David, James P. Hamilton, Tetsuo Ito, Yuriko Mori, Stephen J. Meltzer
  2007 PLoS ONE 2(10): e964. doi:10.1371/journal.pone.0000964
Hypermethylation of Tachykinin-1 is Associated with a Poor Prognosis in Human Esophageal Squamous Cell Carcinoma.
    Jin Z, Olaru A, Yang J, Sato F, Cheng Y, Mori Y, Mantzur C, Paun B, Hamilton JP, Ito T, Kan T, Wang S, David S, Agarwal R, Beer DG, Abraham JM, Meltzer SJ.
    Clin Cancer Res. 2007 Nov 1;13(21):6293-300
Rarity of somatic mutation and frequency of normal sequence variation detected in sporadic colon adenocarcinoma using high-throughput cDNA sequencing.
    Kan T, Paun B, Mori Y, Sato F, Jin Z, Hamilton JP, Ito T, Cheng Y, David S, Olaru A, Yang J, Agarwal R, Abraham JM, Meltzer SJ.
    Bioinformatics & Biology Insights 2007: 1 1-16
Hypermethylation of the nel-like 1 gene is a common and early event and is associated with a poor prognosis in early-stage esophageal adenocarcinoma.
    Jin Z, Mori Y, Yang J, Sato F, Ito T, Cheng Y, Paun B, Hamilton JP, Kan T, Olaru A, David S, Agarwal R, Abraham JM, Beer D, Montgomery E, Meltzer SJ.
    Oncogene. 2007 Sep 20;26(43):6332-40.
Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression
     Hamilton JP, Sato F, Jin Z, Greenwald BD, Ito T, Mori Y, Paun BC, Kan T, Cheng Y, Wang S, Yang J, Abraham JM, Meltzer SJ.
     Clin Cancer Res. 2006 Nov 15;12(22):6637-42.
A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer.
    Mori Y, Cai K, Cheng Y, Wang S, Paun B, Hamilton JP, Jin Z, Sato F, Berki AT, Kan T, Ito T, Mantzur C, Abraham JM, Meltzer SJ.
    Gastroenterology. 2006 Sep;131(3):797-808
RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas.
    Shibata D, Mori Y, Cai K, Zhang L, Yin J, Elahi A, Hamelin R, Wong YF, Lo WK, Chung TK, Sato F, Karpeh MS Jr, Meltzer SJ.
    Int J Cancer. 2006 Aug 15;119(4):801-6.
Thapsigargin resistance in human prostate cancer cells.
      O'Neill JP, Velalar CN, Lee DI, Zhang B, Nakanishi T, Tang Y, Selaru F, Ross D, Meltzer SJ, Hussain A.
      Cancer. 2006 Aug 1;107(3):649-59.
Promoter methylation and response to chemotherapy and radiation in esophageal cancer.
    Hamilton JP, Sato F, Greenwald BD, Suntharalingam M, Krasna MJ, Edelman MJ, Doyle LA, Berki AT, Abraham JM, Mori Y, Kan T, Mantzur C, Paun T, Wang S, Ito T, Jin Z, Meltzer SJ.
    Clin Gastroenterol Hepatol. 2006 Jun;4(6):701-8.
Transcriptional profiling suggests that Barrett's metaplasia is an advanced intermediate stage in esophageal adenocarcinoma.
     Wang S, Zhan M, Yin J, Abraham JM, Mori Y, Sato F, Xu Y, Olaru A, Li H, Schulmann K, Sterian A, Kan T, Hamilton JP, Chai K, Deacu E, Berki AT, Greenwald BD and Meltzer SJ.
     Oncogene 2006 Jun 1; 25(23):3346-3356.
Polo-like kinase and survivin are esophageal tumor-specific promoters.
    Sato F, Abraham JM, Yin J, Kan T, Ito T, Mori Y, Hamilton JP, Jin Z, Cheng Y, Paun B, Berki AT, Wang S, Shimada Y, Meltzer SJ.
    Biochem Biophys Res Commun. 2006 Apr 7;342(2):465-71.
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.
    Takahashi T, Shigematsu H, Shivapurkar N, Reddy J, Zheng Y, Feng Z, Suzuki M, Nomura M, Augustus M, Yin J, Meltzer SJ, Gazdar AF.
    Int J Cancer. 2006 Feb 15;118(4):924-31.
Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma.
    Sterian A, Kan T, Berki AT, Mori Y, Olaru A, Schulmann K, Sato F, Wang S, Paun B, Cai K, Hamilton JP, Abraham JM, Meltzer SJ.
    Oncology. 2006;70(3):168-72. Epub 2006 Jul 7.
A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray.
    Kan T, Yamasaki S, Kondo K, Teratani N, Kawabe A, Kaganoi J, Meltzer SJ, Imamura M, Shimada Y.
    Oncology. 2006;70(1):25-33.
Esophageal cancer epidemiology in blacks and whites: racial and gender disparities in incidence, mortality, survival rates and histology.
    Baquet CR, Commiskey P, Mack K, Meltzer S, Mishra SI.
    J Natl Med Assoc. 2005 Nov;97(11):1471-8.
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma.
    Brabender J, Marjoram P, Lord RV, Metzger R, Salonga D, Vallbohmer D, Schafer H, Danenberg KD, Danenberg PV, Selaru FM, Baldus SE, Holscher AH, Meltzer SJ, Schneider PM.
    Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2113-7.
Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability
    Schulmann K, Mori Y, Croog V, Yin J, Olaru A, Sterian A, Sato F, Wang S, Xu Y, Deacu E, Berki AT, Hamilton JP, Kan T, Abraham JM, Schmiegel W, Harpaz N, Meltzer SJ.
    Gastroenterology. 2005 Jul;129(1):74-85.
Aberrant methylation of Reprimo in human malignancies.
     Takahashi T, Suzuki M, Shigematsu H, Shivapurkar N, Echebiri C, Nomura M, Stastny V, Augustus M, Wu CW, Wistuba II, Meltzer SJ, Gazdar AF.
     Int J Cancer. 2005 Jul 1;115(4):503-10.
Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.
     Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS, Abraham JM, Feng Z, Schmiegel W, Greenwald  BD, Meltzer SJ. Oncogene. 2005 Jun 9;24(25):4138-48.
Prediction of survival in patients with esophageal carcinoma using artificial neural networks.
     Sato F, Shimada Y, Selaru FM, Shibata D, Maeda M, Watanabe G, Mori Y, Stass SA, Imamura M, Meltzer SJ.
     Cancer. 2005 Apr 15;103(8):1596-605. Review.
HNPCC-associated small bowel cancer: clinical and molecular characteristics.
    Schulmann K, Brasch FE, Kunstmann E, Engel C, Pagenstecher C, Vogelsang H, Kruger S, Vogel T, Knaebel HP, Ruschoff J, Hahn SA, Knebel-Doeberitz MV, Moeslein G, Meltzer SJ, Schackert HK, Tympner C, Mangold E, Schmiegel W; The German HNPCC Consortium.
    Gastroenterology. 2005 Mar;128(3):590-9.
Prediction of lymph node metastasis with use of artificial neural networks based on gene expression profiles in esophageal squamous cell carcinoma.
    Kan T, Shimada Y, Sato F, Ito T, Kondo K, Watanabe G, Maeda M, Yamasaki S, Meltzer SJ, Imamura M.
    Ann Surg Oncol. 2004 Dec;11(12):1070-8. Epub 2004 Nov 15.
Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis.
     Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA Jr, Wilson KT.
     Cancer Res. 2004 Dec 1;64(23):8521-5.
Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes.
     Deacu E, Mori Y, Sato F, Yin J, Olaru A, Sterian A, Xu Y, Wang S, Schulmann K, Berki A, Kan T, Abraham JM, Meltzer SJ.
     Cancer Res. 2004 Nov 1;64(21):7690-6.
Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression.
     Kimos MC, Wang S, Borkowski A, Yang GY, Yang CS, Perry K, Olaru A, Deacu E, Sterian A, Cottrell J, Papadimitriou J, Sisodia L, Selaru FM, Mori Y, Xu Y, Yin J, Abraham JM, Meltzer SJ.
     Int J Cancer. 2004 Sep 1;111(3):415-7.
Transcriptional responses of intestinal epithelial cells to infection with Vibrio cholerae.
    Stokes NR, Zhou X, Meltzer SJ, Kaper JB.
    Infect Immun. 2004 Jul;72(7):4240-8.
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus.
    Brabender J, Marjoram P, Salonga D, Metzger R, Schneider PM, Park JM, Schneider S, Holscher AH, Yin J, Meltzer SJ, Danenberg KD, Danenberg PV, Lord RV.
    Oncogene. 2004 Jun 10;23(27):4780-8.
Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning.
    Mori Y, Yin J, Sato F, Sterian A, Simms LA, Selaru FM, Schulmann K, Xu Y, Olaru A, Wang S, Deacu E, Abraham JM, Young J, Leggett BA, Meltzer SJ.
    Cancer Res. 2004 Apr 1;64(7):2434-8.
An unsupervised approach to identify molecular phenotypic components influencing breast cancer features.
     Selaru FM, Yin J, Olaru A, Mori Y, Xu Y, Epstein SH, Sato F, Deacu E, Wang S, Sterian A, Fulton A, Abraham JM, Shibata D, Baquet C, Stass SA, Meltzer SJ.
     Cancer Res. 2004 Mar 1;64(5):1584-8.
Promoter methylation regulates cyclooxygenase expression in breast cancer.
    Ma X, Yang Q, Wilson KT, Kundu N, Meltzer SJ, Fulton AM.
    Breast Cancer Res. 2004;6(4):R316-21. Epub 2004 Apr 26.

                                              Last modified 04/05/2011      

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