|
 |
| For
publications of
before 2004. |
|
Colorectal Cancers
with Microsatellite Instability Display Unique miRNA Profiles. |
| Balaguer F,
Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M,
Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X,
Castells A, Boland CR, Gironella M, Goel A. |
| Clin Cancer
Res. 2011 Oct 1;17(19):6239-6249. Epub 2011 Aug 15. |
Germline mutations in MTB1,
ANBC1 and CHDC1 in individuals with Barrett esophagus and/or
esophageal adenocarcinoma. |
| Orloff M,
Peterson C, Ganapathi S, He X, Heald B, Bebek G, Romigh T, Song
JH, Wu W, David S, Cheng Y, Meltzer SJ,* Eng C. |
| JAMA 2011,
in press. *Co-corresponding and co-senior author |
Unique patterns
of CpG island methylation in inflammatory bowel
disease-associated colorectal cancers. |
| Olaru AV,
Cheng Y, Agarwal R, Yang J, David S, Abraham JM, Yu W, Lazarev
M, Brant SR, Marohn MR, Hutcheon DF, Harpaz N, Meltzer SJ, Mori
Y. |
| Inflamm.
Bowel Dis. 2011, in press. |
Strong
inhibition of xenografted tumor growth by low-level doses of
[32P]ATP. |
| Cheng Y,
Yang J, Agarwal R, Green GM, Mease RC, Pomper MG, Meltzer SJ,
Abraham JM. |
| Oncotarget
2011 Jun 5 [Epub]. |
Novel candidate
colorectal cancer biomarkers identified by methylation
microarray-based scanning. |
| Mori Y,
Olaru AV, Cheng Y, Agarwal R, Yang J, Luvsanjav D, Yu W, Lazarev
M, Kwon JH, Brant SR, Hutcheon DF, Duncan MD, Goel A, Meltzer SJ. |
| Endocr.-Related
Cancer 2011 Jun 2 [Epub]. |
A DNA methylation blueprint of
1,628 human samples |
| Fernandez
AF, Assnov Y, Martin-Subero I, Balin B, Siebert R, Taniguchi H,
Yamamoto H, Hidalgo M, Tan A-C, Galm O, Ferrer I, Sanchez-Cespedes
M, Villaneuva A, Carmona J, Sanchez-Mut JV, Berdasco M, Moreno
V, Capella G, Monk D, Ballestar E, Ropero S, Martinez R,
Sanchez-Carbayo M, Prosper F, Agirre X, Fraga MF, Grana O,
Perz-Jurado L, Mora J, Puig S, Prat J, Badimon L, Puca AA,
Meltzer SJ, Lengauer T, Bridgewater J, Bock C, Esteller M. |
| Genome Res.
2011 May 25 [Epub] |
Genetic
variation in DNA-repair pathways and response to
radiochemotherapy in esophageal adenocarcinoma: a retrospective
cohort study of the Eastern Cooperative Oncology Group. |
| Yoon HH, Catalano
PJ, Murphy KM, Skaar TC, Philips S, Powell M, Montgomery EA,
Hafez MJ, Offer SM, Liu G, Meltzer SJ, Wu X, Forastiere AA,
Benson AB, Kleinberg LR, Gibson MK. |
| BMC Cancer
2011 May 17; 11(1):176 [Epub]. |
Widespread
hypomethylation occurs early and synergizes with gene
amplification during esophageal carcinogenesis. |
| Alvarez H,
Opalinska J, Zhou L, Sohal D, Fazzari M, Yu Y, Montagna C,
Montgomery E, Canto M, Dunbar K, Wang J, Roa JC, Mo Y, Bhagat T,
Ramesh KH, Cannizzaro L, Mollenhauer J, Thompson R, Suzuki M,
Meltzer SJ, Melnick A, Greally J, Maitra A, Verma A. |
| PLoS Genet 2011,
7(3): e1001356. doi:10.1371/journal.pgen.10 |
Dynamic
changes in the expression of microRNA-31 during inflammatory
bowel disease-associated neoplastic transformation.
|
| Olaru AV, Selaru
F, Mori Y, Vazquez C, David S, Paun BC, Cheng Y, Jin Z, Yang, J,
Agarwal R, Abraham JM, Dassopoulos T, Harpaz N, Bayless T, Kwon
J, Livak F, Meltzer SJ. |
| Inflammatory Bowel
Diseases 2011 Jan;17(1):221-31; PMID: 20848542. |
Polo-like
kinase 1 regulates cell proliferation and is targeted by
miR-593* in esophageal cancer. |
| Ito T, Sato F, Kan
T, Cheng Y, David S, Agarwal R, Paun BC, Jin Z, Olaru AV,
Hamilton JP, Selaru FM, Yang J, Matsumura N, Shimizu K, Abraham
JM, Shimada Y, Mori Y, Meltzer SJ.
|
| Int. J. Cancer
2010 Dec 17. [Epub ahead of print] PMID: 21170987. |
MicroRNAs
-192 and -215 are upregulated in human gastric cancer and
suppress ALCAM expression in vitro. |
| Jin Z, Cheng Y,
Kan T, Mori Y, Agarwal R, Olaru AV, Yang J, Hamilton JP, David
S, Abraham JM, Montgomery EA, Meltzer SJ. |
| Oncogene 2010 Nov
29 [Epub ahead of print] PMID: 21119604. |
SILAC-based
quantitative proteomic approach to identify potential biomarkers
from the esophageal squamous cell carcinoma secretome. |
| Kashyap MK, Harsha
HC, Renuse S, Pawar H, Sahasrabuddhe NA, Kim M-S, Marimuthu A,
Keerthikumar S, Muthusamy B, Kandasamy K, Subbannayya Y, Prasad
TSK, Mahmood R, Chaerkady R, Meltzer SJ, Kumar RV, Rustgi AK,
Pandey A. |
| Cancer Biol. Ther.
2010 Oct 7;10(8). [Epub ahead of print] PMID: 20686364. |
Identification of
microRNAs associated with ileal and colonic Crohn's disease. |
| Wu F, Zhang
S, Dassopoulos T, Harris ML, Bayless TM, Meltzer SJ, Brant SR,
Kwon JH. |
| Inflammatory
Bowel Diseases 2010 Oct;16(10):1729-38; PMID: 20848482. |
Overexpression
of periostin and lumican in esophageal squamous cell carcinoma |
| Kashyap MK,
Marimuthu A, Peri S, Ghantasala S, Kumar S, Jacob HKC, Prasad
TSK, Mahmood R, Veerendra Kumar KV, Kumar M, Meltzer SJ,
Montgomery EA, Kumar RV, Pandey A. |
| Cancers 2010,
2(1), 133-142; doi:10.3390/cancers2010133 - published online 1
March 2010. |
Relationship
between normal rectal methylation, smoking status, and the
presence or absence of colorectal adenomas |
| Bogdan C. Paun,
Debra Kukuruga, Zhe Jin, Yuriko Mori, Yulan Cheng, Mark Duncan,
Sanford A. Stass, Elizabeth Montgomery, David Hutcheon and
Stephen J. Meltzer |
| Cancer. 2010 Oct
1;116(19):4495-501. |
Silencing
of Claudin-11 Is Associated with Increased Invasiveness of
Gastric Cancer Cells |
| Rachana Agarwal,
Yuriko Mori, Yulan Cheng, Zhe Jin, Alexandru V. Olaru, James P.
Hamilton, Stefan David, Florin M. Selaru, Jian Yang, John M.
Abraha1, Elizabeth Montgomery, Patrice J.Morin, Stephen J.
Meltzer |
|
PLoS One. 2009 Nov;4(11):e8002. |
MicroRNAs
in Barrett's esophagus and esophageal adenocarcinoma |
| Kan T, Stephen J.
Meltzer. |
| Current Opinion in
Pharmacology Corresponding. 2009, 9:727–732 |
Screening
for Microsatellite Instability Identifies Frequent
3'-Untranslated Region Mutation of the RB1-Inducible Coiled-Coil
1 Gene in Colon Tumors |
| Bogdan C. Paun,
Yulan Cheng, Barbara A. Leggett, Joanne Young, Stephen J.
Meltzer, Yuriko Mori |
|
PLoS One. 2009 Nov 2;4(11):e7715. |
Chromosomal abnormalities and novel disease-related regions in
progression from Barrett’s esophagus to esophageal
adenocarcinoma |
| Akagi
T, Ito T,
Kato M,
Jin Z,
Cheng Y, Kan
T, Yamamoto G, Olaru
A, Kawamata
N, Boult J, Soukiasian
J, Miller C, Ogawa
S, Meltzer
SJ, Koeffler HP |
|
International Journal of Cancer, 2009 Nov
15;125(10):2349-59. |
A
Multicenter, Double-Blinded Validation Study of Methylation
Biomarkers for Progression Prediction in Barrett’s
Esophagus |
| Jin Z, Cheng Y, Zheng Y, Gu J, Sato F, Olaru AV, Paun B, Yang J, Kan T, Ito T,
Hamilton JP, Selaru FM, Mori Y, Agarwal R, David S, Abraham JM,
Wolfsen H, Shaheen NJ, Wang J, Canto M, Washington K, Romero Y,
Wang KK, Feng Z, Sampliner RD, Meltzer SJ. |
|
Cancer Res. 2009, May 15; 69(10): 4112-4115. |
The
miR-106b-25 polycistron, activated by genomic amplification,
functions as an oncogene by suppressing p21 and Bim |
|
Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R,
Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J,
Abraham JM, Mori Y, Meltzer SJ. |
|
Gastroenterology. 2009 May;136(5):1689-700. |
MicroRNA-21 is overexpressed in human cholangiocarcinoma and
regulates programmed cell death 4 and tissue inhibitor of
metalloproteinase 3. |
| Selaru FM, Olaru
AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z,
Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H,
Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores
GJ, LaRusso NF, Hruban R, Meltzer SJ. |
|
Hepatology. 2009 May;49(5):1595-601. |
Generation
of Small 32P-Labeled Peptides as a Potential Approach
to Colorectal Cancer Therapy |
|
John M. Abraham, Yulan Cheng, James P. Hamilton, Bogdan Paun, Zhe Jin, Rachana
Agarwal, Takatsugu
Kan, Stefan David, Alexandru Olaru, Jian Yang, Tetsuo Ito,
Florin M. Selaru, Yuriko
Mori, Stephen J. Meltzer |
|
PLoS ONE. 2008 June; 3(6): e2508. |
Three-tiered
Risk Stratification Model to Predict Progression in Barrett’s
Esophagus Using Epigenetic and Clinical Features |
| Sato F, Jin Z,
Schulmann K, Wang J, Greenwald B, Ito T, Kan T, Hamilton JP,
Yang J, Paun B, David S, Olaru A, Cheng Y, Mori Y, Abraham
JM, Yfantis H, Wu T, Fredericksen M, Wang K, Canto M,
Romero Y, Feng Z, Meltzer SJ. |
| PLoS ONE. 2008 Apr 2; 3(4):e1890. |
PTTG1
increases cell motility and promotes lymph node metastasis in
esophageal squamous cell carcinoma |
| Ito T, Shimada Y,
Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru
A, Hamilton JP, Yang J, Abraham JM, Meltzer SJ, Sato F |
| Cancer Research.
2008 May 1;68(9):3214-3224 |
Hypermethylation
of the AKAP12 Promoter is a Biomarker of Barrett's-Associated
Esophageal Neoplastic Progression |
| Jin Z, Hamilton
JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun
B, David S, Agarwal R, Abraham JM, Meltzer SJ. |
| Cancer Epidemiology
Biomarkers & Prevention. 2008, Jan 1; 17 111-117. |
Hypermethylation
of the somatostatin promoter is a common, early event in human
esophageal carcinogenesis.
|
|
Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Paun
B, Kan T, Agarwal R, Meltzer SJ. |
|
Cancer. 2008 Jan 1;112(1):43-9. |
Novel
Decapeptides that Bind Avidly and Deliver Radioisotope to Colon
Cancer Cells |
| John
M. Abraham, Fumiaki Sato, Yulan Cheng, Bogdan Paun, Takatsugu
Kan, Alexandru Olaru, Zhe Jin, Jian Yang, Rachana
Agarwal, Stefan David, James P. Hamilton, Tetsuo Ito, Yuriko
Mori, Stephen J. Meltzer |
| 2007 PLoS ONE 2(10): e964.
doi:10.1371/journal.pone.0000964 |
Hypermethylation
of Tachykinin-1 is Associated with a Poor Prognosis in Human
Esophageal Squamous Cell Carcinoma. |
|
Jin Z, Olaru A, Yang J, Sato F, Cheng
Y, Mori Y, Mantzur C, Paun B, Hamilton JP, Ito T, Kan T, Wang S,
David S, Agarwal R, Beer DG, Abraham JM, Meltzer SJ. |
|
Clin Cancer Res. 2007 Nov 1;13(21):6293-300 |
Rarity
of somatic mutation and frequency of normal sequence variation
detected in sporadic colon adenocarcinoma using
high-throughput cDNA sequencing. |
| Kan T, Paun B,
Mori Y, Sato F, Jin Z, Hamilton JP, Ito T, Cheng Y, David S,
Olaru A, Yang J, Agarwal R, Abraham JM, Meltzer SJ. |
| Bioinformatics &
Biology Insights 2007: 1 1-16 |
Hypermethylation
of the nel-like 1 gene is a common and early event and is
associated with a poor prognosis in early-stage esophageal
adenocarcinoma. |
|
Jin Z, Mori Y, Yang J, Sato F, Ito
T, Cheng Y, Paun B, Hamilton JP, Kan T, Olaru A, David S,
Agarwal R, Abraham JM, Beer D, Montgomery E, Meltzer SJ. |
| Oncogene. 2007 Sep
20;26(43):6332-40. |
Reprimo
methylation is a potential biomarker of Barrett's-Associated
esophageal neoplastic progression. |
|
Hamilton JP, Sato F, Jin Z, Greenwald BD, Ito T, Mori Y, Paun
BC, Kan T, Cheng Y, Wang S, Yang J, Abraham JM, Meltzer SJ.
|
|
Clin Cancer Res. 2006 Nov 15;12(22):6637-42. |
A
genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer. |
| Mori Y, Cai K,
Cheng Y, Wang S, Paun B, Hamilton JP, Jin Z, Sato F, Berki AT,
Kan T, Ito T, Mantzur C, Abraham JM, Meltzer SJ. |
| Gastroenterology.
2006 Sep;131(3):797-808 |
RAB32 hypermethylation and
microsatellite instability in gastric and endometrial
adenocarcinomas. |
| Shibata D, Mori Y,
Cai K, Zhang L, Yin J, Elahi A, Hamelin R, Wong YF, Lo WK, Chung
TK, Sato F, Karpeh MS Jr, Meltzer SJ. |
| Int J Cancer. 2006
Aug 15;119(4):801-6. |
Thapsigargin resistance in human
prostate cancer cells. |
| O'Neill
JP, Velalar CN, Lee DI, Zhang B, Nakanishi T, Tang Y, Selaru F,
Ross D, Meltzer SJ, Hussain A. |
| Cancer.
2006 Aug 1;107(3):649-59. |
Promoter methylation and response to
chemotherapy and radiation in esophageal cancer. |
| Hamilton JP, Sato
F, Greenwald BD, Suntharalingam M, Krasna MJ, Edelman MJ, Doyle
LA, Berki AT, Abraham JM, Mori Y, Kan T, Mantzur C, Paun T, Wang
S, Ito T, Jin Z, Meltzer SJ. |
| Clin Gastroenterol
Hepatol. 2006 Jun;4(6):701-8. |
Transcriptional profiling suggests that Barrett's metaplasia is
an advanced intermediate stage in esophageal adenocarcinoma. |
| Wang S, Zhan
M, Yin J, Abraham JM, Mori Y, Sato F, Xu Y, Olaru A, Li H,
Schulmann K, Sterian A, Kan T, Hamilton JP, Chai K, Deacu E,
Berki AT, Greenwald BD and Meltzer SJ. |
| Oncogene 2006
Jun 1; 25(23):3346-3356. |
Polo-like kinase and survivin are
esophageal tumor-specific promoters. |
| Sato F, Abraham JM,
Yin J, Kan T, Ito T, Mori Y, Hamilton JP, Jin Z, Cheng Y, Paun
B, Berki AT, Wang S, Shimada Y, Meltzer SJ. |
| Biochem Biophys Res
Commun. 2006 Apr 7;342(2):465-71. |
Aberrant promoter methylation of
multiple genes during multistep pathogenesis of colorectal
cancers. |
|
Takahashi T, Shigematsu H, Shivapurkar N, Reddy J, Zheng Y, Feng
Z, Suzuki M, Nomura M, Augustus M, Yin J, Meltzer SJ, Gazdar AF. |
|
Int J Cancer. 2006 Feb 15;118(4):924-31. |
Mutational and LOH analyses of
the chromosome 4q region in esophageal adenocarcinoma. |
| Sterian A, Kan T,
Berki AT, Mori Y, Olaru A, Schulmann K, Sato F, Wang S, Paun B,
Cai K, Hamilton JP, Abraham JM, Meltzer SJ. |
| Oncology. 2006;70(3):168-72. Epub
2006 Jul 7. |
A new specific gene expression in
squamous cell carcinoma of the esophagus detected using
representational difference analysis and cDNA microarray. |
| Kan T, Yamasaki S,
Kondo K, Teratani N, Kawabe A, Kaganoi J, Meltzer SJ, Imamura M,
Shimada Y. |
| Oncology.
2006;70(1):25-33. |
Esophageal cancer epidemiology in
blacks and whites: racial and gender disparities in incidence,
mortality, survival rates and histology. |
| Baquet CR,
Commiskey P, Mack K, Meltzer S, Mishra SI. |
| J Natl
Med Assoc. 2005 Nov;97(11):1471-8. |
The molecular signature of normal
squamous esophageal epithelium identifies the presence of a
field effect and can discriminate between patients with
Barrett's esophagus and patients with Barrett's-associated
adenocarcinoma. |
| Brabender J,
Marjoram P, Lord RV, Metzger R, Salonga D, Vallbohmer D, Schafer
H, Danenberg KD, Danenberg PV, Selaru FM, Baldus SE, Holscher
AH, Meltzer SJ, Schneider PM. |
|
Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2113-7.
|
Molecular phenotype of inflammatory
bowel disease-associated neoplasms with microsatellite
instability |
| Schulmann K, Mori
Y, Croog V, Yin J, Olaru A, Sterian A, Sato F, Wang S, Xu Y,
Deacu E, Berki AT, Hamilton JP, Kan T, Abraham JM, Schmiegel W,
Harpaz N, Meltzer SJ. |
| Gastroenterology. 2005
Jul;129(1):74-85. |
Aberrant methylation of Reprimo in
human malignancies. |
| Takahashi T,
Suzuki M, Shigematsu H, Shivapurkar N, Echebiri C, Nomura M,
Stastny V, Augustus M, Wu CW, Wistuba II, Meltzer SJ, Gazdar AF.
|
| Int J Cancer.
2005 Jul 1;115(4):503-10. |
Inactivation of p16, RUNX3, and HPP1
occurs early in Barrett's-associated neoplastic progression and
predicts progression risk. |
|
Schulmann K,
Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori
Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS,
Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ. Oncogene. 2005 Jun
9;24(25):4138-48. |
Prediction of survival in patients
with esophageal carcinoma using artificial neural networks. |
| Sato F,
Shimada Y, Selaru FM, Shibata D, Maeda M, Watanabe G, Mori Y,
Stass SA, Imamura M, Meltzer SJ. |
|
Cancer. 2005 Apr
15;103(8):1596-605. Review. |
HNPCC-associated small bowel cancer:
clinical and molecular characteristics. |
| Schulmann K, Brasch
FE, Kunstmann E, Engel C, Pagenstecher C, Vogelsang H, Kruger S,
Vogel T, Knaebel HP, Ruschoff J, Hahn SA, Knebel-Doeberitz MV,
Moeslein G, Meltzer SJ, Schackert HK, Tympner C, Mangold E,
Schmiegel W; The German HNPCC Consortium. |
| Gastroenterology. 2005
Mar;128(3):590-9. |
Prediction of lymph node metastasis
with use of artificial neural networks based on gene expression
profiles in esophageal squamous cell carcinoma. |
|
Kan T, Shimada Y, Sato F, Ito T, Kondo K, Watanabe G, Maeda M,
Yamasaki S, Meltzer SJ, Imamura M. |
|
Ann Surg Oncol. 2004 Dec;11(12):1070-8. Epub 2004 Nov 15. |
Spermine oxidation induced by
Helicobacter pylori results in apoptosis and DNA damage:
implications for gastric carcinogenesis. |
| Xu H,
Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D,
Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero
RA Jr, Wilson KT. |
|
Cancer Res.
2004 Dec 1;64(23):8521-5. |
Activin type II receptor restoration
in ACVR2-deficient colon cancer cells induces transforming
growth factor-beta response pathway genes. |
| Deacu E, Mori
Y, Sato F, Yin J, Olaru A, Sterian A, Xu Y, Wang S, Schulmann K,
Berki A, Kan T, Abraham JM, Meltzer SJ. |
| Cancer Res.
2004 Nov 1;64(21):7690-6. |
Esophagin and proliferating cell
nuclear antigen (PCNA) are biomarkers of human esophageal
neoplastic progression. |
| Kimos MC,
Wang S, Borkowski A, Yang GY, Yang CS, Perry K, Olaru A, Deacu
E, Sterian A, Cottrell J, Papadimitriou J, Sisodia L, Selaru FM,
Mori Y, Xu Y, Yin J, Abraham JM, Meltzer SJ. |
|
Int J Cancer. 2004 Sep 1;111(3):415-7. |
Transcriptional responses of
intestinal epithelial cells to infection with Vibrio cholerae. |
|
Stokes NR, Zhou X, Meltzer SJ, Kaper JB. |
| Infect Immun. 2004
Jul;72(7):4240-8. |
A multigene expression panel for the
molecular diagnosis of Barrett's esophagus and Barrett's
adenocarcinoma of the esophagus. |
|
Brabender J, Marjoram P, Salonga D, Metzger R, Schneider PM,
Park JM, Schneider S, Holscher AH, Yin J, Meltzer SJ, Danenberg
KD, Danenberg PV, Lord RV. |
| Oncogene. 2004 Jun
10;23(27):4780-8. |
Identification of genes uniquely
involved in frequent microsatellite instability colon
carcinogenesis by expression profiling combined with epigenetic
scanning. |
|
Mori Y, Yin J, Sato F, Sterian A, Simms LA, Selaru FM, Schulmann
K, Xu Y, Olaru A, Wang S, Deacu E, Abraham JM, Young J, Leggett
BA, Meltzer SJ. |
| Cancer Res. 2004 Apr
1;64(7):2434-8. |
An unsupervised approach to identify
molecular phenotypic components influencing breast cancer
features. |
| Selaru FM,
Yin J, Olaru A, Mori Y, Xu Y, Epstein SH, Sato F, Deacu E, Wang
S, Sterian A, Fulton A, Abraham JM, Shibata D, Baquet C, Stass
SA, Meltzer SJ. |
|
Cancer Res.
2004 Mar 1;64(5):1584-8. |
Promoter methylation regulates
cyclooxygenase expression in breast cancer. |
|
Ma X, Yang Q, Wilson KT, Kundu N, Meltzer SJ, Fulton AM. |
| Breast Cancer Res.
2004;6(4):R316-21. Epub 2004 Apr 26. |
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