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Research Interest:
Previously, the majority of my experimental work utilized siRNA
knockdown techniques and microarray technology to identify and
characterize downstream genetic targets of regulator genes.
Recently, I have been involved in identifying novel decapeptides
that, when labeled with 32P radioisotope, can transfer this
tumor-ablating agent to colon and esophageal adenocarcinoma cells.
Selected
Publication: 1. Blount PL, Galipeau PC, Sanchez CA,
Neshat K, Levine DS, Yin J, Suzuki H, Abraham JM, Meltzer SJ, Reid
BJ. 17p allelic losses in diploid cells of patients with Barrett's
esophagus who develop aneuploidy. Cancer Res. 1994; 54:2292-2295.
2. Meltzer SJ, Yin J, Manin B, Rhyu M-G, Cottrell J, Hudson E, Redd
JL, Krasna MJ, Abraham JM, Reid BJ. Microsatellite instability
occurs frequently and in both diploid and aneuploid cell populations
of Barrett's-associated esophageal adenocarcinomas. Cancer Res.
1994; 54:3379-3382.
3. Suzuki H, Harpaz N, Tarmin Y, Yin J, Jiang H-Y, Bell JD,
Hontanosas M, Groisman GM, Abraham JM, Meltzer SJ. Microsatellite
instability in ulcerative colitis-associated colorectal dysplasias
and cancers. Cancer Res. 1994; 54:4841-4844.
4. Harpaz N, Peck AL, Yin J, Fiel I, Hontanosas M, Tong TR, Laurin
JN, Abraham JM, Greenwald BD, Meltzer SJ. p53 protein expression in
ulcerative colitis-associated colorectal dysplasia and carcinoma.
Human Pathol. 1994; 25:1069-1074.
5. Zhou X, Tarmin L, Yin J, Jiang H-Y, Suzuki H, Rhyu M-G, Abraham
JM, Meltzer SJ. The MTS1 gene is frequently mutated in primary human
esophageal tumors. Oncogene 1994; 9:3737-3741.
6. Tarmin L, Yin J, Zhou X, Suzuki H, Jiang H-Y, Abraham JM, Krasna
MJ, Cottrell J, Meltzer SJ. Frequent loss of heterozygosity on
chromosome 9 in adenocarcinoma and squamous cell carcinoma of the
esophagus. Cancer Res. 1994; 54:6094-6096.
7. Balcer-Kubiczek EK, Yin J, Lin K, Harrison GH, Abraham JM,
Meltzer SJ. p53 mutational status and survival of human breast
cancer MCF7 cell variants after exposure to X-rays or fission
neutrons. Radiation Res. 1995; 142:256-262.
8. Zhou X, Suzuki H, Shimada Y, Imamura M, Yin J, Jiang H-Y, Tarmin
L, Abraham JM, Meltzer SJ. Genomic DNA and messenger RNA expression
alterations of the CDKN2B and CDKN2 genes in esophageal squamous
carcinoma cell lines. Genes, Chromosomes & Cancer 1995; 13:285-290.
9. Suzuki H, Zhou X, Yin J, Lei J, Jiang H-Y, Suzuki Y, Abraham JM,
Chan T, Hannon GJ, Mergner WJ, Abraham JM, Meltzer SJ. Intragenic
mutations of p15 and p16 in primary human esophageal cancers. Human
Molec. Genet. 1995; 4:1883-1888.
10. Berg PE, Liu J, Yin J, Rhyu M-G, Frantz CN, Meltzer SJ.
Microsatellite instability is infrequent in neuroblastoma. Cancer
Epidemiology, Biomarkers & Prevention 1995; 4:907-909.
11. Abraham JM, Wang S, Suzuki H, Jiang H-Y, Rosenblum-Vos LS, Yin
J, Meltzer SJ. Esophagin cDNA cloning and characterization: a
tissue-specific member of the small proline-rich protein family that
is not expressed in esophageal tumors. Cell Growth & Different.
1996; 7:855-860.
12. Zhou X, Suzuki H, Lei J, Cole K, Yin J, Suzuki Y, Abraham JM,
Shimada Y, Imamura T, Chan JT, Hannon GJ, Meltzer SJ. Growth
suppression of esophageal cancer cells by p16INK4 and p15INK4B in
vitro. Cancer J. Sci. Am. 1996; 2:221-224.
13. Souza RF, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou
T-T, Shi Y-Q, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett
B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J,
Meltzer SJ. Microsatellite instability in the insulin-like growth
factor II receptor gene in gastrointestinal tumors. Nature Genet.
1996; 14:255-257.
14. Lei J, Zou T-T, Shi Y-Q, Smolinski KN, Yin J, Souza RF, Appel R,
Wang S, Cymes K, Chan O, Harpaz N, Abraham JM, Meltzer SJ.
Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer,
and ulcerative colitis-associated neoplasms. Oncogene 1996;
13:2459-2462.
15. Balcer-Kubiczek EK, Harrison GH, Zhang X-F, Shi Z-M, Abraham JM,
McCready WA, Ampey III LL, Meltzer SJ, Jacobs MC, Davis CC. Rodent
cell transformation and immediate early gene expression following
60-Hz magnetic field exposure. Envir. Health Perspect. 1996;
104:1188-1198.
16. Souza RF, Lei J, Yin J, Appel R, Zou T-T, Zhou X, Wang S, Rhyu
M-G, Cymes K, Chan O, Park W-S, Krasna MJ, Greenwald BD, Cottrell J,
Abraham JM, Harpaz N, Meltzer SJ. A transforming growth factor-1
receptor type II mutation occurs in ulcerative colitis-associated
and sporadic colorectal neoplasms. Gastroenterol. 1997; 112:40-45.
17. Balcer-Kubiczek EK, Meltzer SJ, Han L-H, Zhang X-F, Zhong M-S,
Harrison GH, Qin JT, Abraham JM. Csa-19, a radiation-responsive
human gene, identified by an unbiased two-gel cDNA library screening
method. Oncogene 1997; 14:3051-3058.
18. Souza RF, Yin J, Smolinski KN, Zou T-T, Wang S, Shi Y-Q, Rhyu
M-G, Cottrell J, Abraham JM, Biden K, Simms L, Leggett B, Bova GS,
Frank T, Powell SM, Sugimura H, Young J, Harpaz N, Shimizu K,
Matsubara N, Meltzer SJ. Frequent mutation of the E2F-4 cell cycle
gene in primary human gastrointestinal tumors. Cancer Res. 1997;
57:2350-53.
19. Zou T-T, Lei J, Shi Y-Q, Yin J, Wang S, Souza RF, Smolinski KN,
Greenwald BD, Abraham JM, Harpaz N, Meltzer SJ. FHIT gene
alterations in ulcerative colitis (UC) and esophageal cancer.
Oncogene 1997; 15:101-105.
20. Wang S, Souza RF, Kong D, Yin J, Smolinski KN, Zou T-T, Young J,
Flanders K, Sugimura H, Abraham JM, Meltzer SJ. Deficient
transforming growth factor-1 activation and excessive insulin-like
growth factor II expression in IGFII receptor-mutant tumors. Cancer
Res. 1997; 57:2543-2546.
21. Kong D, Suzuki A, Zou T-T, Sakurada A, Kemp LW, Wakatsuki S,
Yokoyama T, Yamakawa H, Furukawa T, Sato M, Ohuchi N, Sato S, Yin J,
Wang S, Abraham JM, Souza RF, Smolinski KN, Meltzer SJ, Horii A.
PTEN1 is frequently mutated in primary endometrial carcinomas.
Nature Genet. 1997; 17:143-144.
22. Yin J, Kong D, Wang S, Zou T-T, Souza RF, Smolinski KN, Lynch
PM, Frazier M, Hamilton SR, Sugimura H, Powell SM, Young J, Abraham
JM, Meltzer SJ. Mutation of the hMSH3 and hMSH6 mismatch repair
genes in genetically unstable human colorectal and gastric
carcinomas. Human Mutation 1997; 10:474-478.
23. Zou T, Fleisher AS, Kong D, Yin J, Souza RF, Wang S, Smolinski
KN, Abraham JM, Meltzer SJ. Sequence alterations of IGFBP-3 in
neoplastic and normal gastrointestinal tissues. Cancer Res. 1998;
58:4802-4804.
24. Balcer-Kubiczek EK, Zhang XF, Han LH, Harrison GH, Davis CC,
Zhou XJ, Ioffe V, McCready WA, Abraham JM, Meltzer SJ. BIGEL
analysis of gene expression in HL60 cells exposed to X rays or 60 Hz
magnetic fields. Radiation Res. 1998; 150:663-672.
25. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin Y, Zou
T-T, Abraham JM, Kong D, Smolinski KN, Shi Y-Q, Rhyu M-G, Powell SM,
James SP, Wilson KT, Herman JG, Meltzer SJ. Hypermethylation of the
hMLH1 gene promoter in human gastric cancers with microsatellite
instability. Cancer Res. 1999; 59:1090-1095.
26. Yin J, Harpaz N, Souza RF, Zou T, Kong D, Wang S, Leytin AL,
Medalie NS, Smolinski KN, Abraham JM, Fleisher AS, Meltzer SJ. Low
prevalence of the APC I1307K sequence in patients with inflammatory
bowel disease. Oncogene 1999; 18:3902-3904.
27. Souza RF, Wang S, Thakar M, Grubb J, Smolinski KN, Yin J, Zou
T-T, Kong D, Gable CA, Sly WS, Abraham JM, Toretsky JA, Meltzer SJ.
Expression of the wild-type insulin-like growth factor II receptor
gene suppresses growth and causes death in colorectal carcinoma
cells. Oncogene 1999; 18:4063-4068.
28. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D,
Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S,
Motoyama T, Meltzer SJ. E-cadherin gene promoter hypermethylation in
primary gastric carcinomas. J. Natl. Cancer Inst. 2000; 92:569-573.
29. Fleisher AS, Esteller M, Leytin A, Harpaz N, Rashid A, Xu Y,
Liang J, Stine OC, Yin J, Zou T-T, Abraham JM, Kong D, Wilson KT,
James SP, Herman JG, Meltzer SJ. Microsatellite instability in IBD-associated
neoplastic lesions is associated with hypermethylation and
diminished expression of the DNA mismatch repair gene, hMLH1. Cancer
Res. 2000; 60:4864-4868.
30. Kawakami, K., Brabender, J., Lord, R.V., Groshen, S., Greenwald,
B.D., Krasna, M.J., Yin, J., Fleisher, A.S., Abraham, J.M., Beer,
D.G., Sidransky, D., Huss, H.T., DeMeester, T.R., Eads, C.A., Laird,
P.W., Ilson, D.H., Kelsen, D.P., Harpole, D., Moore, M.-B.,
Danenberg, K.D., Danenberg, P.V., Meltzer S.J. Hypermethylated APC
promoter DNA in serum and prognosis in esophageal adenocarcinoma
patients. J. Natl. Cancer Inst. 2000; 92:1805-1811.
31. Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J,
Zou TT, Abraham JM, Kong D, Nishizuka S, James SP, Wilson KT, Herman
JG, Meltzer SJ. Hypermethylation of the hMLH1 gene promoter is
associated with microsatellite instability in early human gastric
neoplasia. Oncogene 2001; 20:329-335.
32. Selaru F, Zou T, Shustova V, Xu Y, Yin J, Mori Y, Sato F, Wang
S, Shibata D, Greenwald BD, Krasna MJ, Abraham JM, Meltzer SJ.
Global gene expression profiling in Barrett’s esophagus and
esophageal cancer: a comparative analysis using cDNA microarrays.
Oncogene 2002; 21:475-478.
33. Sato F, Harpaz N, Shibata D, Xu Y, Yin J, Mori Y, Zou T-T, Wang
S, Desai K, Leytin A, Selaru F, Abraham JM, Meltzer SJ.
Hypermethylation of the p14ARF gene in ulcerative colitis-associated
colorectal carcinogenesis. Cancer Res. 2002; 62:1148-1151.
34. Selaru F, Xu Y, Yin J, Zou T, Liu TC, Mori Y, Abraham JM, Sato
F, Wang S, Twigg C, Olaru A, Shustova V, Leytin A, Shibata D, Harpaz
N, Meltzer SJ. Artificial neural networks distinguish among subtypes
of neoplastic colorectal lesions. Gastroenterol. 2002; 122:606-613.
35. Smolinski KN, Abraham JM, Souza RF, Yin J, Wang S, Xu Y, Zou
T-T, Kong D, Fleisher AS, Meltzer SJ. A functional promoter for the
squamous differentiation marker esophagin that is activated during
differentiation of cultured esophageal cells. Genomics 2002;
79:875-880.
36. Xu Y, Selaru FM, Yin J, Zou TT, Shustova V, Mori Y, Sato F, Liu
TC, Olaru A, Wang S, Kimos MC, Perry K, Desai K, Greenwald BD,
Krasna MJ, Shibata D, Abraham JM, Meltzer SJ. Artificial neural
networks and gene filtering distinguish between global gene
expression profiles of Barrett’s esophagus and esophageal cancer.
Cancer Res. 2002; 62:3493-3497.
37. Zou T, Selaru F, Xu Y, Yin J, Shustova V, Mori Y, Sato F, Liu TC,
Abraham JM, Meltzer SJ. Application of cDNA microarrays to generate
a molecular taxonomy capable of distinguishing between colon cancer
and normal colon. Oncogene 2002; 21:4855-4862.
38. Mori Y, Selaru FM, Olaru A, Perry K, Kimos MC, Tamura G,
Matsubara N, Sato F, Wang S, Xu Y, Yin J, Zou T-T, Leggett B, Young
J, Nukiwa T, Stine OC, Abraham JM, Shibata D, Meltzer SJ.
Instabilotyping reveals novel unique mutational spectra in
microsatellite-unstable gastric cancers. Cancer Res. 2002;
62:3641-3645.
39. Shibata DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru
A, Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ.
Hypermethylation of HPP1 is associated with hMLH1 hypermethylation
in gastric adenocarcinomas. Cancer Res. 2002 Oct 15; 62(20):5637-40.
40. Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru
A, Deacu E, Selaru F, Kimos M, Hytiroglou P, Young J, Leggett B,
Gazdar AF, Toyooka S, Abraham JM, Meltzer SJ. Aberrant methylation
of the HPP1 gene in ulcerative colitis-associated colorectal
carcinoma. Cancer Res. 2002 Dec 1; 62(23):6820-6822.
41. Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos MC,
Perry K, Selaru FM, Deacu E, Sun M, Shi YC, Shibata D, Abraham JM,
Greenwald BD, Meltzer SJ. An LOH and mutational investigation of the
ST7 gene locus in human esophageal carcinoma. Oncogene 2003 Jan 23;
22(3):467-470.
42. Mori Y, Selaru F, Sato F, Xu Y, Wang S, Yin J, Abraham JM, Olaru
A, Deacu E, Kimos M, Perry K, Shibata D, Young J, Leggett B, Meltzer
SJ. The impact of microsatellite instability on the molecular
phenotype of colorectal tumors. Cancer Res. 2003 Aug 1;
63(15):4577-4582.
43. Olaru A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F,
Selaru FM, Deacu E, Shibata D, Abraham JM, Meltzer SJ. An LOH and
mutational analysis of the ACTRII gene locus in human colorectal
tumors. Lab. Invest. 2003 Dec; 83(12):1867-1861.
44. Selaru FM, Yin J, Xu Y, Epstein S, Sato F, Mori Y, Olaru A,
Deacu E, Wang S, Sterian A, Fulton A, Abraham JM, Shibata D, Baquet
C, Stass SA, Meltzer SJ. An unsupervised approach to identify
molecular phenotypic components influencing breast cancer features.
Cancer Res. 2004 Mar 1; 64(5):1584-1588.
45. Mori Y, Yin J, Sato F, Sterian A, Simms LA, Selaru FM, Xu Y,
Olaru A, Wang S, Deacu E, Abraham JM, Young J, Leggett BA, Meltzer
SJ. Identification of genes uniquely involved in MSI-H colon
carcinogenesis by expression profiling combined with epigenetic
scanning. Cancer Res. 2004 Apr 1; 64(7):2434-2438.
46. Schulmann K, Yin J, Sterian A, Xu T, Sato F, Bryant L, Mori Y,
Olaru A, Deacu E, Wang S, Brenner DE, Krasna MJ, Abraham JM, Baron
JA, Greenwald BD, Meltzer SJ. Methylation profiling for the
prediction of Barrett’s esophagus progression. Gastroenterol. 2004
Jul; 127(1):331.
47. Kimos MC, Borkowski A, Wang LD, Yang CS, Perry K, Olaru A,
Sisodia L, Selaru FM, Mori Y, Xu Y, Yin J, Wang S, Abraham JM,
Meltzer SJ. Esophagin and proliferating cell nuclear antigen (PCNA)
as biomarkers of human esophageal epithelial differentiation and
proliferation in carcinogenesis. Int. J. Cancer 2004 Sep 1;
111(3):415-417.
48. Deacu E, Mori Y, Sato F, Yin J, Olaru A, Sterian A, Xu Y, Wang
S, Schulmann K, Bryant L, Kan T, Abraham JM, Meltzer SJ. Activin
type II receptor restoration in ACVR2-deficient colon cancer cells
induces TGF-beta response pathway genes. Cancer Res. 2004 Nov 1;
64(21):7690-7696.
49. Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A,
Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe
MS, Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ.
Inactivation of p16, RUNX3, and HPP1 occurs early in
Barrett's-associated neoplastic progression and predicts progression
risk. Oncogene 2005 Jun 9; 24(25):4138-4148.
50. Schulmann K, Mori Y, Croog V, Yin J, Olaru A, Sterian A, Sato F,
Wang S, Xu Y, Deacu E, Abraham JM, Schmiegel W, Harpaz N, Meltzer SJ.
Molecular phenotype of inflammatory bowel disease-associated
neoplasms with microsatellite instability. Gastroenterol. 2005 Jul;
129:74-85.
51. Sato F, Abraham JM, Yin J, Kan T, Ito T, Mori Y, Hamilton JP,
Jin Z, Cheng Y, Paun B, Berki AT, Wang S, Shimada T, Meltzer SJ.
Polo-like kinase (PLK) and Survivin are Esophageal Tumor-Specific
Promoters. Biochem. Biophys. Res. Commun. 2006 Apr 7;
342(2):465-471.
52. Wang S, Zhan M, Yin J, Abraham JM, Mori Y, Sato F, Xu Y, Olaru
A, Li H, Schulmann K, Sterian A, Kan T, Hamilton JP, Chai K, Deacu
E, Berki AT, Greenwald BD and Meltzer SJ. Transcriptional profiling
supports that Barrett's metaplasia is an advanced intermediate stage
in esophageal adenocarcinoma. Oncogene 2006 Jun 1; 25(23):3346-3356.
53. Hamilton JP, Sato F, Greenwald BD, Suntharalingam M, Krasna MJ,
Edelman MJ, Doyle LA, Berki AT, Abraham JM, Mori Y, Kan T, Mantzur
C, Paun T, Wang S, Ito T, Jin Z, Meltzer SJ. Promoter
hypermethylation and response to chemotherapy and radiation in
esophageal cancer. Clin. Gastroenterol. Hepatol. 2006 Jun;
4(6):701-708.
54. Sterian A, Kan T, Mori Y, Berki A, Olaru A, Schulmann K, Sato F,
Wang S, Paun B, Cai K, Hamilton JP, Abraham JM, Greenwald BD,
Meltzer SJ. Mutational and deletion analyses of the chromosome
4q24-31 region in esophageal adenocarcinoma. Oncology 2006 Jul 7;
70(3):168-172.
55. Mori Y, Cai K, Cheng Y, Wang S, Paun B, Hamilton JP, Jin Z, Sato
F, Berki AT, Kan T, Ito T, Mantzur C, Abraham JM, Meltzer SJ. A
genome-wide search identifies epigenetic silencing of somatostatin,
tachykinin-1, and five other genes in colon cancer. Gastroenterol.
2006 Sep; 131(3): 797-808.
56. Hamilton JP, Sato F, Jin Z, Greenwald BD, Ito T, Mori Y, Paun B,
Kan T, Cheng Y, Wang S, Mantzur C, Abraham JM, Meltzer SJ. Reprimo
methylation is a potential early biomarker of Barrett’s-associated
neoplastic progression. Clin. Cancer Res. 2006 Nov 15;
12(22):6637-6642.
57.Kan T, Paun B, Mori Y, Sato F, Jin Z, Hamilton JP, Ito T, Cheng
Y, David S, Olaru A, Yang J, Agarwal R, Abraham JM, Meltzer SJ.
Rarity of somatic mutation and frequency of normal sequence
variation detected in sporadic colon adenocarcinoma using
high-throughput cDNA sequencing. Bioinformatics & Biology Insights
2007; 1:1-16.
58. Abraham JM, Sato F, Cheng Y, Paun B, Ito T, Kan T, Olaru A, Jin
Z, Yang J, Agarwal R, David S, Hamilton JP, Mori Y, Meltzer SJ. A
Novel Decapeptide that Binds Avidly and Delivers Radioisotope to
Colon Cancer Cells. PLoS ONE 2007 Oct 3;2(10):e964.
59. Jin Z, Olaru A, Yang J, Sato F, Cheng Y, Mori Y, Mantzur C, Paun
B, Hamilton JP, Ito T, Kan T, Wang S, David S, Agarwal R, Beer DG,
Abraham JM, Meltzer SJ. Hypermethylation of Tachykinin-1 is
Associated with a Poor Prognosis in Human Esophageal Squamous Cell
Carcinoma. Clin. Cancer Res. 2007 Nov 1;13(21):6293-6300.
60. Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Paun
B, Kan T, Agarwal R, Meltzer SJ. Hypermethylation of the
somatostatin promoter is a common, early event in human esophageal
carcinogenesis. Cancer 2008 Jan 1;112(1):43-49.
147. Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan
T, Cheng Y, Paun B, David S, Agarwal R, Abraham JM, Meltzer SJ.
Hypermethylation of the AKAP12 Promoter is a Potential Biomarker of
Barrett's-Associated Esophageal Neoplastic Progression. Cancer
Epidemiology, Biomarkers & Prevention 2008 Jan; 17(1):1-16.
61. Selaru FM, Wang S, Yin J, Schulmann K, Xu Y, Yuriko Mori Y,
Olaru A, Sato F, Hamilton JP, Abraham JM, Schneider P, Greenwald BD,
Brabender J, Meltzer SJ. Beyond Field Effect: Analysis of Shrunken
Centroids in Normal Esophageal Epithelia Detects Concomitant
Esophageal Adenocarcinoma. Bioinformatics & Biology Insights, 2007;
1:127-136.
62. Ito T, Shimada Y, Kan T, David S, Abraham JM, Mori Y, Agarwal R,
Cheng Y, Paun B, Jin Z, Olaru A, Hamilton JP, Yang J, Meltzer SJ,
Sato F. PTTG1 promotes lymph node metastasis in esophageal squamous
cell carcinoma by increasing cell motility. Cancer Research 2008 May
1;68(9):3214-3224.
63. Sato F, Jin Z, Schulmann K, Wang J, Greenwald BD, Ito T, Kan T,
Hamilton JP, Yang J, Paun B, David S, Olaru A, Cheng Y, Mori Y,
Abraham JM, Yfantis HG, Wu T, Fredericksen MB, Wang KK, Canto M,
Romero Y, Feng Z, Meltzer SJ. Three-tiered risk stratification
method to predict progression in Barrett’s esophagus using
epigenetic and clinical features. PLoS ONE 2008 Apr 2; 3(4):e1890.
64. Ito T, Tanaka E, Kadowaki T, Kan T, Higashiyama M, Shiojima S,
Tomoda S, Myoumoto A, Akiyama H, Nobumasa H, Matsumoto S, Miyamoto
S, Mitsumori M, Sato F, Watanabe G, Itami A, Meltzer SJ, Tsujimoto
G, Shimada Y. An ultrasensitive new DNA microarray chip provides
gene expression profiles for preoperative esophageal cancer biopsies
without RNA amplification. Oncology 2008 May 30, 73(5-6):366-375.
65. Abraham JM, Cheng Y, Hamilton JP, Paun B, Jin Z, Agarwal R, Kan
T, David S, Olaru A, Yang J, Ito T, Selaru FM, Mori Y, Meltzer SJ.
Generation of small 32P-labeled peptides as a potential approach to
colorectal cancer therapy. PLoS ONE 2008 Jun 25; 3(6):e2508.
66. Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan
T, Cheng Y, Paun B, David S, Agarwal R, Abraham JM, Meltzer SJ.
Promoter hypermethylation of CDH13 is a common, early event in human
esophageal adenocarcinogenesis and correlates with clinical risk
factors. Int. J. Cancer 2008 Nov 15;123(10):2331-2336.
67. Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J,
Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham JM, Georgiades C,
Alvarez H, Vivekanandan P, Maitra A, Torbenson M, Thuluvath PJ,
Gores GJ, LaRusso NF, Hruban R, Meltzer SJ. MicroRNA-21 is
overexpressed in human cholangiocarcinoma and regulates programmed
cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology
2009 Feb 4;49(5):1595-1601.
68. Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R,
Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM,
Mori Y, Meltzer SJ. The miR-25-93-106b polycistron, activated by de
novo genomic amplification, functions as an oncogene by suppressing
p21 and Bim. Gastroenterol. 2009 May;136(5):1689-700.
69. Jin Z, Cheng Y, Zheng Y, Gu J, Sato F, Olaru AV, Paun B, Yang J,
Kan T, Ito T, Hamilton JP, Selaru FM, Mori Y, Agarwal R, David S,
Abraham JM, Wolfsen H, Shaheen NJ, Wang J, Canto M, Washington K,
Romero Y, Wang KK, Feng Z, Sampliner RD, Meltzer SJ. A multi-center,
double-blinded validation study of methylation biomarkers for
progression prediction in Barrett’s esophagus. Cancer Res. 2009, in
press.
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