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Dr. Florin Selaru
Assistant Professor
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Research Interest: Gastrointestinal cancers. IBD. Bioinformatics and data analysis. Proteomics. Selected Publication: 1. Selaru FM, Zou T, Xu Y, Shustova V, Yin J, Mori Y, Sato F, Wang S, Olaru A, Greenwald BD, Krasna MJ, Abraham JM, Meltzer SJ. Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays., - Oncogene, Vol. 21, Issue 3, p. 475-8, 2002 2. Sato F, Harpaz N, Xu Y, Yin J, Mori Y, Zou T, Wang S, Desai K, Leytin A, Selaru FM, Abraham JM, and Meltzer SJ. Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis, Cancer Research., Vol. 62, Issue 4, p. 1148-51, 2002 3. Selaru FM, Xu Y, Yin J, Zou T, Liu TC, Mori Y, Abraham JM, Sato F, Wang S, Twigg C, Olaru A, Shustova V, Leytin A, Hytiroglou P, Shibata D, Harpaz N and Meltzer SJ. Artificial Neural Networks distinguish among subtypes of neoplastic colorectal lesions. Gastroenterology, Vol. 122, Issue 3, p. 606-13, 2002 4. Rus V, Atamas SP, Shustova V, Luzina IG, Selaru FM, Laurence S. Magder, and Charles S Via. Expression of Cytokine and Chemokine-Related Genes in Peripheral Blood Mononuclear Cells from Lupus Patients by cDNA Array. Clinical Immunology. Vol. 102, Issue 3, p. 283-90, 2002 5. Zou T, Selaru FM, Xu Y, Shustova V, Yin J, Mori Y, Shibata D., Sato F, Wang S, Olaru A, Deacu E, Liu T, Abraham JM, Meltzer SJ. Application of cDNA microarrays to generate a molecular taxonomy distinguishing between colon cancer and normal colon. Oncogene, 18;21(31):4855-62, 2002 6. Xu Y, Selaru FM, Yin J, Zou T, Shustova V, Mori Y, Sato F, Liu TC, Olaru A, Wang S, Kimos MC, Perry K, Desai K, Greenwald BD, Krasna MJ, Shibata D, Abraham JM, Meltzer SJ. - Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer. Cancer Research, Vol. 62, Issue 12, p. 3493-7, 2002 7. Mori Y, Sato F, Selaru FM, Olaru A, Perry K, Kimos M, Tamura G, Matsubara N, Wang S, Xu Y, Yin J, Zou T-T, Leggett B, Young J, Nukiwa T, Stine OC, Abraham JM, Shibata D, Meltzer SJ. Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. , Cancer Research. Vol. 62, Issue 13, p. 3641-5, 2002 8. Shibata, D M, Sato, F, Mori, Y, Perry, K, Yin, J, Wang, S, Xu, Y, Olaru, A, Selaru FM, Spring, K, Young, J, Abraham, J M, Meltzer, S J Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. , Cancer Research, Vol. 20, Issue 20, p. 5637-5640, 2002 9. Sato, F, Shibata, D, Harpaz, N, Xu, Y, Yin, J, Mori, Y, Wang, S, Olaru, A, Deacu, E, Selaru FM, Kimos, M C, Hytiroglou, P, Young, J, Leggett, B, Gazdar, A F, Toyooka, S, Abraham, J M, Meltzer, S J , Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma., Cancer Research, Vol. 62, Issue 23, p. 6820-2, 2002 10. Wang, S, Mori, Y, Sato, F, Yin, J, Xu, Y, Zou, T T, Olaru, A, Kimos, M C, Perry, K, Selaru FM, Deacu, E, Sun, M, Shi, Y C, Shibata, D, Abraham, J M, Greenwald, B D, Meltzer, S J , An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma, Oncogene, Vol. 22, Issue 3, p. 467-70, 2003 11. Mori Y, Selaru FM, Sato F, Yin J, Simms LA, Xu Y, Olaru A, Deacu E, Wang S, Taylor JM, Young J, Leggett B, Jass JR, Abraham JM, Shibata D, Meltzer SJ The impact of microsatellite instability on the molecular phenotype of colorectal tumors.Cancer Res. 2003 Aug 1;63(15):4577-82. 12. Olaru, A, Mori, Y, Yin, J, Wang, S, Kimos MC, Perry K, Xu, Y, Sato, F, Selaru FM, Deacu, E, Sterian A, Shibata, D, Abraham, JM, Meltzer, SJ Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors. Lab Invest. 2003 Dec;83(12):1867-71. 13. Selaru FM, Yin J, Olaru A, Mori Y, Xu Y, Epstein SH, Sato F, Deacu E, Wang S, Sterian A, Fulton A, Abraham JM, Shibata D, Baquet C, Stass SA, Meltzer SJ. An unsupervised approach to identify molecular phenotypic components influencing breast cancer features. Cancer Res. 2004 Mar 1;64(5):1584-8. 14. Mori Y, Yin J, Sato F, Sterian A, Simms LA, Selaru FM, Schulmann K, Xu Y, Olaru A, Wang S, Deacu E, Abraham JM, Young J, Leggett BA, Meltzer SJ. Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning. Cancer Res. 2004 Apr 1;64(7):2434-8. 15. Kimos MC, Wang S, Borkowski A, Yang GY, Yang CS, Perry K, Olaru A, Deacu E, Sterian A, Cottrell J, Papadimitriou J, Sisodia L, Selaru FM, Mori Y, Xu Y, Yin J, Abraham JM, Meltzer SJ. Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression. Int J Cancer. 2004 Sep 1;111(3):415-7. 16. Sato F, Shimada Y, Selaru FM, Shibata D, Maeda M, Watanabe G, Mori Y, Stass SA, Imamura M, Meltzer SJ. Prediction of survival in patients with esophageal carcinoma using artificial neural networks. Cancer. 2005 Apr 15;103(8):1596-605. 17. Brabender J, Marjoram P, Lord RV, Metzger R, Salonga D, Vallbohmer D, Schafer H, Danenberg KD, Danenberg PV, Selaru FM, Baldus SE, Holscher AH, Meltzer SJ, Schneider PM. The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma.Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2113-7. 18. O'Neill JP, Velalar CN, Lee DI, Zhang B, Nakanishi T, Tang Y, Selaru FM, Ross D, Meltzer SJ, Hussain A. Thapsigargin resistance in human prostate cancer cells. Cancer. 2006 Aug 1;107(3):649-59. 19. Selaru FM, Cross R, Drachenberg C, Cross R. Electronic clinical challenges and images in GI. Fibrolamellar carcinoma. Gastroenterology. 2007 Nov;133(5):e1-3. 20. Selaru FM, Wang S, Yin J, Schulmann K, Xu Y, Mori Y, Olaru AV, Sato F, Hamilton JP, Abraham JM, Schneider P, Greenwald BD, Brabender J, Meltzer SJ. Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma. Bioinform Biol Insights. 2007;1:127-136. 21. Abraham JM, Cheng Y, Hamilton JP, Paun B, Jin Z, Agarwal R, Kan T, David S, Olaru A, Yang J, Ito T, Selaru FM, Mori Y, Meltzer SJ. Generation of small 32P-labeled peptides as a potential approach to colorectal cancer therapy. PLoS ONE. 2008 Jun 25;3(6):e2508. 22. Jin Z, Cheng Y, Olaru A, Kan T, Yang J, Paun B, Ito T, Hamilton JP, David S, Agarwal R, Selaru FM, Sato F, Abraham JM, Beer DG, Mori Y, Shimada Y, Meltzer SJ. Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. Int J Cancer. 2008 Nov 15;123(10):2331-6. 23. Selaru FM, Mullin GE. Gastrointestinal stromal tumor causing obscure-occult gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2009 Apr;7(4):e20. Epub 2008 Oct 22. 24. Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H, Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores GJ, LaRusso NF, Hruban R, Meltzer SJ. MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology. 2009 May;49(5):1595-601. 25. Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM, Mori Y, Meltzer SJ. The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim. Gastroenterology. 2009 May;136(5):1689-700.
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Last modified 05/13/2009 |
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