Selected Recent Publications:

1. Baker, R.P., Young K., Feng L., Shi Y. and S. Urban. Enzymatic analysis of a rhomboid intramembrane proteases implicates transmembrane helix 5 as the lateral substrate gate. (2007). Proc. Natl. Acad. Sci. USA, 104 (20): 8257-62.   [from the cover article]

2. Wu Z., Yan N.,Feng L., Oberstein A., Yan H., Baker R. P., Gu L., Jeffrey P.D.,Urban S., and Y. Shi.  Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. (2006). Nature Structural and Molecular Biology 13 (12): 1084-1091.
                    
3. Urban S. Rhomboid proteins: conserved membrane proteases with divergent biological functions. (2006). Genes and Development 20 (22): 3054-3068.

4. Baker, R.P., Wijetilaka R, andS. Urban. Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria. (2006). PLoS Pathogens10(2): e113.

5. Brossier F., Jewett T., Sibley D. L., andS. Urban. A spatially-localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. (2005). Proc. Natl. Acad. Sci. USA, 102(11):4146-4151.

6. Urban S. and M. S. Wolfe. Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. (2005). Proc. Natl. Acad. Sci. USA, 102(6):1883-1888.

7. Kanaoka M.,Urban S., Freeman M., and K. Okada. An Arabidopsis rhomboid homolog is an intramembrane protease in plants. (2005).FEBS Letters 529(25):5723-5728.

8. Urban S., Brown G., and M. Freeman. EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development (2004).Development131: 1835-1845.

9. Urban S. and M. Freeman. Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. (2003).Molecular Cell11: 1425-1434.

10. Urban S., Schlieper D., and M. Freeman. Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids (2002).Current Biology12: 1507-1512.

11. Urban S., Lee J. R., and M. Freeman.  A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF-like ligands (2002).EMBO Journal 21: 4277-4286.

12. Urban S., Lee J. R., and M. Freeman. Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases. (2001). Cell 107 (2): 173-182.