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TITLE Spontaneous Induction of Arrhythmias during Ischemia Phase 1B AUTHORS Xiao Jie, Blanca Rodríguez , and Natalia Trayanova ABSTRACT The mechanisms of initiation and sustenance of lethal ventricular arrhythmias during regional ischemia phase 1b, referring to 20-30 min after coronary occlusion, are still not well understood. Possible mechanisms include spontaneous activations resulting from Na overload and the coupling between the ischemic subepicardium and the non-excitable midmyocardium. The goal of this study is to assemble a model of the rabbit ventricle with detailed representation of pathological conditions and examine the trigger and the substrate necessary to initiate and maintain arrhythmias.