Return to: Molecular Biology and Genetics
Research
Curriculum Vitae
Publications
Requests for Mice & Reagents
Media
Home
Se-Jin Lee, MD, PhD
Professor
Johns Hopkins University School of Medicine
Molecular Biology & Genetics
725 N. Wolfe Street
803 PCTB
Baltimore, MD 21205
 
Office: 410-614-0198
Fax: 410-614-7079
Email:

Mouse Strains

STRAIN

DESCRIPTION

REFERENCE

AVAILABILITY

Mstn (Gdf8)
knockout

deletion of
C-terminal
domain

Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee  (1997)  Regulation of skeletal muscle mass in mice by a new TGF-ß superfamily member.  Nature 387:83-90

available

Gdf11

knockout

deletion of
C-terminal
domain

Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee  (1999)  Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor-11.  Nature Genet. 22:260-264

available

Gdf10

knockout

deletion of
C-terminal
domain

Renbin Zhao, Ann M. Lawler, and
Se-Jin Lee  (1999)  Characterization of GDF-10 expression patterns and null mice.  Dev. Biol. 212:68-79

available

Gdf1

knockout

deletion of
C-terminal
domain

Christopher T. Rankin, Tracie Bunton, Ann M. Lawler, and Se-Jin Lee  (2000)  Regulation of left-right patterning in mice by growth/differentiation factor-1.  Nature Genet. 24:262-265

deposited at Jackson Labs

Gdf15

knockout

deletion of
C-terminal
domain

Edward C. Hsiao, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris, Suzanne M. Sebald, Thanh Huynh, and Se-Jin Lee  (2000)  Characterization of growth/differentiation factor-15 (Gdf15):  a TGF-ß superfamily member induced following liver injury.  Mol. Cell. Biol. 20:3742-3751

available

mdx/Mstn
knockout

deletion of Mstn
C-terminal
domain on mdx
background

Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, and
Se-Jin Lee  (2002)  Loss of myostatin attenuates severity of muscular dystrophy in mdx mice.  Ann. Neurol.  52:832-836

available

MLC/myostatin
propeptide
transgenic

myosin light
chain promoter/
enhancer

Se-Jin Lee and Alexandra C. McPherron  (2001)  Regulation of myostatin activity and muscle growth.  Proc. Natl. Acad. Sci., USA 98:9306-9311

available

MLC/follistatin
transgenic

myosin light
chain promoter/
enhancer

Se-Jin Lee and Alexandra C. McPherron  (2001)  Regulation of myostatin activity and muscle growth.  Proc. Natl. Acad. Sci., USA 98:9306-9311

available

MLC/dominant
negative Acvr2b
transgenic

myosin light
chain promoter/
enhancer

Se-Jin Lee and Alexandra C. McPherron  (2001)  Regulation of myostatin activity and muscle growth.  Proc. Natl. Acad. Sci., USA 98:9306-9311

available

MLC/Flrg
transgenic

myosin light
chain promoter/
enhancer

Se-Jin Lee  (2007)  Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways.  PLoS ONE 2(8):e789.  doi:10.1371/journal.pone.0000789

available

Flrg (Fstl3)-flox  

Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton  (2010)  Regulation of muscle mass by follistatin and activins.  Mol. Endocrinol. 24:1998-2008

available

Flrg (Fstl3) deletion  

Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton  (2010)  Regulation of muscle mass by follistatin and activins.  Mol. Endocrinol. 24:1998-2008

available

MLC/cre

myosin light
chain promoter/
enhancer

Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee  (2009)  Redundancy of myostatin and growth/differentiation factor 11 function.  BMC Dev. Biol. 9:24.  doi:10.1186/1471-213X-9-24.

available

Gdf11-flox  

Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee  (2009)  Redundancy of myostatin and growth/differentiation factor 11 function.  BMC Dev. Biol. 9:24.  doi:10.1186/1471-213X-9-24.

available

Mstn D76A

point mutation
rendering the
propeptide
protease-resistant

Se-Jin Lee  (2008)  Genetic analysis of the role of proteolysis in the activation of latent myostatin.  PLoS ONE 3(8):e1628.  doi:10.1371/journal.pone.0001628

available

Tll2 knockout

Deletion of
exon 7

Se-Jin Lee  (2008)  Genetic analysis of the role of proteolysis in the activation of latent myostatin.  PLoS ONE 3(8):e1628.  doi:10.1371/journal.pone.0001628

available

Tll1 knockout  

unpublished

pending
publication

Tll1-flox

 

unpublished

pending
publication

Bmp1 knockout  

unpublished

pending
publication

Bmp1-flox  

unpublished

pending
publication

Mstn-flox  

unpublished

pending
publication

Smad2-flox  

unpublished

pending
publication

Bmp9 (Gdf2)

knockout

deletion of
C-terminal
domain

unpublished

pending
publication

Inhbc knockout

deletion of
C-terminal
domain

unpublished

pending
publication

Inhbe (Gdf12) knockout

deletion of
C-terminal
domain

unpublished

pending
publication

Inhbc/Inhbe double knockout

deletion of entire Inhbc/Inhbe locus

Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton  (2010)  Regulation of muscle mass by follistatin and activins.  Mol. Endocrinol. 24:1998-2008

available

MLC/rtTA
MLC/tetR-KRAB

myosin light
chain promoter/
enhancer

unpublished

pending
publication

 

Copyright © 2006 The Johns Hopkins University. All Rights Reserved
Site designed by Academic Web Pages