STRAIN |
DESCRIPTION |
REFERENCE |
AVAILABILITY |
Mstn (Gdf8)
knockout |
deletion of
C-terminal
domain |
Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1997) Regulation of skeletal muscle mass in mice by a new TGF-ß superfamily member. Nature 387:83-90 |
available |
| Gdf11 knockout |
deletion of
C-terminal
domain |
Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1999) Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor-11. Nature Genet. 22:260-264 |
available |
| Gdf10 knockout |
deletion of
C-terminal
domain |
Renbin Zhao, Ann M. Lawler, and
Se-Jin Lee (1999) Characterization of GDF-10 expression patterns and null mice. Dev. Biol. 212:68-79 |
available |
| Gdf1 knockout |
deletion of
C-terminal
domain |
Christopher T. Rankin, Tracie Bunton, Ann M. Lawler, and Se-Jin Lee (2000) Regulation of left-right patterning in mice by growth/differentiation factor-1. Nature Genet. 24:262-265 |
deposited at Jackson Labs |
| Gdf15 knockout |
deletion of
C-terminal
domain |
Edward C. Hsiao, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris, Suzanne M. Sebald, Thanh Huynh, and Se-Jin Lee (2000) Characterization of growth/differentiation factor-15 (Gdf15): a TGF-ß superfamily member induced following liver injury. Mol. Cell. Biol. 20:3742-3751 |
available |
mdx/Mstn
knockout |
deletion of Mstn
C-terminal
domain on mdx
background |
Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, and
Se-Jin Lee (2002) Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann. Neurol. 52:832-836 |
available |
MLC/myostatin
propeptide
transgenic |
myosin light
chain promoter/
enhancer |
Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 |
available |
MLC/follistatin
transgenic |
myosin light
chain promoter/
enhancer |
Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 |
available |
MLC/dominant
negative Acvr2b
transgenic |
myosin light
chain promoter/
enhancer |
Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 |
available |
MLC/Flrg
transgenic |
myosin light
chain promoter/
enhancer |
Se-Jin Lee (2007) Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways. PLoS ONE 2(8):e789. doi:10.1371/journal.pone.0000789 |
available |
| Flrg (Fstl3)-flox |
|
Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol. 24:1998-2008 |
available |
| Flrg (Fstl3) deletion |
|
Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol. 24:1998-2008 |
available |
MLC/cre |
myosin light
chain promoter/
enhancer |
Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee (2009) Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev. Biol. 9:24. doi:10.1186/1471-213X-9-24. |
available |
| Gdf11-flox |
|
Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee (2009) Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev. Biol. 9:24. doi:10.1186/1471-213X-9-24. |
available |
| Mstn D76A |
point mutation
rendering the
propeptide
protease-resistant |
Se-Jin Lee (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3(8):e1628. doi:10.1371/journal.pone.0001628 |
available |
Tll2 knockout |
Deletion of
exon 7 |
Se-Jin Lee (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3(8):e1628. doi:10.1371/journal.pone.0001628 |
available |
| Tll1 knockout |
|
unpublished |
pending
publication |
Tll1-flox |
|
unpublished |
pending
publication |
| Bmp1 knockout |
|
unpublished |
pending
publication |
| Bmp1-flox |
|
unpublished |
pending
publication |
| Mstn-flox |
|
unpublished |
pending
publication |
| Smad2-flox |
|
unpublished |
pending
publication |
| Bmp9 (Gdf2) knockout |
deletion of
C-terminal
domain |
unpublished |
pending
publication |
| Inhbc knockout |
deletion of
C-terminal
domain |
unpublished |
pending
publication |
| Inhbe (Gdf12) knockout |
deletion of
C-terminal
domain |
unpublished |
pending
publication |
| Inhbc/Inhbe double knockout |
deletion of entire Inhbc/Inhbe locus |
Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol. 24:1998-2008 |
available |
MLC/rtTA
MLC/tetR-KRAB |
myosin light
chain promoter/
enhancer |
unpublished |
pending
publication |
