Peer Reviewed Publications

Daniel Linzer, Se-Jin Lee, Linda Ogren, Frank Talamantes, and Daniel Nathans (1985) Identification of proliferin mRNA and protein in mouse placenta. Proc. Natl. Acad. Sci., USA 82:4356-4359. [PDF reprint]

Se-Jin Lee and Daniel Nathans (1987) Secretion of proliferin. Endocrinology 120:208-213. [PDF reprint]

Se-Jin Lee and Daniel Nathans (1988) Proliferin secreted by cultured cells binds to mannose-6-phosphate receptors. J. Biol. Chem. 263:3521-3527. [PDF reprint]

Se-Jin Lee, Frank Talamantes, Elizabeth Wilder, Daniel Linzer, and Daniel Nathans (1988) Trophoblastic giant cells of the mouse placenta as the site of proliferin synthesis. Endocrinology 122:1761-1768. [PDF reprint]

Se-Jin Lee (1990) Expression of HSP86 in male germ cells. Mol. Cell. Biol. 10:3239-3242. [PDF reprint]

Se-Jin Lee (1990) Identification of a novel member (GDF-1) of the transforming growth factor-ß superfamily. Mol. Endocrinol. 4:1034-1040. [PDF reprint]

Se-Jin Lee (1991) Expression of growth/differentiation factor-1 in the nervous system: Conservation of a bi-cistronic structure. Proc. Natl. Acad. Sci., USA 88:4250-4254. [PDF reprint]

Alexandra C. McPherron and Se-Jin Lee (1993) GDF-3 and GDF-9: Two new members of the transforming growth factor-ß superfamily containing a novel pattern of cysteines. J. Biol. Chem. 268:3444-3449. [PDF reprint]

Elaine E. Storm, Thanh V. Huynh, Neal G. Copeland, Nancy A. Jenkins, David M. Kingsley, and Se-Jin Lee (1994) Limb alterations in brachypodism mice due to mutations in a new member of the TGF-ß superfamily. Nature 368:639-643. [PDF reprint]

Sharon A. McGrath, Aurora F. Esquela, and Se-Jin Lee (1995) Oocyte-specific expression of growth/differentiation factor-9. Mol. Endocrinol. 9:131-136. [PDF reprint]

Noreen S. Cunningham, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, A. Hari Reddi, and Se-Jin Lee (1995) Growth/Differentiation Factor-10: A new member of the transforming growth factor-ß superfamily related to bone morphogenetic protein-3. Growth Factors 12:99-109. [PDF reprint]

Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1997) Regulation of skeletal muscle mass in mice by a new TGF-ß superfamily member. Nature 387:83-90. [PDF reprint]

Aurora F. Esquela, Teresa A. Zimmers, Leonidas G. Koniaris, James V. Sitzmann, and Se-Jin Lee (1997) Transient down-regulation of inhibin-ßC expression following partial hepatectomy. Biochem. Biophys. Res. Comm. 235:553-556. [PDF reprint]

Alexandra C. McPherron and Se-Jin Lee (1997) Doubling muscling in cattle due to mutations in the myostatin gene. Proc. Natl. Acad. Sci., USA 94:12457-12461. [PDF reprint]

Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1999) Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor-11. Nature Genet. 22:260-264. [PDF reprint]

Renbin Zhao, Ann M. Lawler, and Se-Jin Lee (1999) Characterization of GDF-10 expression patterns and null mice. Dev. Biol. 212:68-79. [PDF reprint]

Christopher T. Rankin, Tracie Bunton, Ann M. Lawler, and Se-Jin Lee (2000) Regulation of left-right patterning in mice by growth/differentiation factor-1. Nature Genet. 24:262-265. [PDF reprint]

Edward C. Hsiao, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris, Suzanne M. Sebald, Thanh Huynh, and Se-Jin Lee (2000) Characterization of growth/differentiation factor-15 (Gdf15): a TGF-ß superfamily member induced following liver injury. Mol. Cell. Biol. 20:3742-3751. [PDF reprint]

Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311. [PDF reprint]

Alexandra C. McPherron and Se-Jin Lee (2002) Suppression of body fat accumulation in myostatin-deficient mice. J. Clin. Invest. 109:595-601. [PDF reprint]

Teresa A. Zimmers, Monique V. Davies, Leonidas G. Koniaris, Paul Haynes, Aurora F. Esquela, Kathy N. Tomkinson, Alexandra C. McPherron, Neil M. Wolfman, and Se-Jin Lee (2002) Induction of cachexia in mice by systemically administered myostatin. Science 296:1486-1488. [PDF reprint] [supplemental information]

Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, and Se-Jin Lee (2002) Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann. Neurol. 52:832-836. [PDF reprint]

Aurora F. Esquela and Se-Jin Lee (2003) Regulation of metanephric kidney development by growth/differentiation factor 11. Dev. Biol. 257:356-370. [PDF reprint]

Neil M. Wolfman, Alexandra C. McPherron, William N, Pappano, Monique V. Davies, Kening Song, Kathleen N. Tomkinson, Jill F. Wright, Liz Zhao, Suzanne M. Sebald, Daniel S. Greenspan, and Se-Jin Lee (2003) Activation of latent myostatin by the BMP-1/tolloid family of metolloproteinases. Proc. Natl. Acad. Sci., USA 100:15842-15846. [PDF reprint]

Markus Schuelke, Kathryn R. Wagner, Leslie Stolz, Christoph Hubner, Thomas Riebel, Wolfgang Komen, Thomas Braun, James F. Tobin, and Se-Jin Lee (2004) Gross muscle hypertrophy in a child associated with a myostatin (GDF-8) mutation. New Engl. J. Med. 350 :2682-2688. [PDF reprint]

Se-Jin Lee, Lori A. Reed, Monique V. Davies, Stefan Girgenrath, Mary E.P. Goad, Kathy N. Tomkinson, Jill F. Wright, Christopher Barker, Gregory Ehrmantraut, James Holmstrom, Betty Trowell, Barry Gertz, Man-Shiow Jiang, Suzanne M. Sebald, Martin Matzuk, En Li, Li-fang Liang, Edwin Quattlebaum, Ronald L. Stotish, and Neil M. Wolfman (2005) Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc. Natl. Acad. Sci., USA 102:18117-18122. [PDF reprint]

Se-Jin Lee  (2007)  Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways.  PLoS ONE 2(8):e789.  doi:10.1371/journal.pone.0000789. [PDF reprint]

Se-Jin Lee  (2008)  Genetic analysis of the role of proteolysis in the activation of latent myostatin.  PLoS ONE 3(8):e1628.  doi:10.1371/journal.pone.0001628. [PDF reprint]

Review Articles and Commentaries

Alexandra C. McPherron and Se-Jin Lee (1996) The transforming growth factor-ß superfamily. In Growth Factors and Cytokines in Health and Disease, vol. 1B. D. LeRoith and C. Bondy, eds. JAI Press, Inc., Greenwich, CT, pp. 357-393.

Se-Jin Lee and Alexandra C. McPherron (1999) Myostatin and the control of skeletal muscle mass. Curr. Opin. Genet. Dev. 9:604-607. [PDF reprint]

Se-Jin Lee (2004) Regulation of muscle mass by myostatin. Ann. Rev. Cell Dev. Biol. 20:61-86. [PDF reprint]

Se-Jin Lee (2007) Sprinting without myostatin: a genetic determinant of athletic prowess. Trends Genet. 23:475-477. [PDF reprint]