[recent publications]

2023

• R. M. Linville, J. Maressa, Z. Guo, T. D. Chung, A. Farrell, R. Jha, and P. C. Searson. "A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer," Fluids & Barriers CNS 20, e80 (2023). [DOI:10.1186/s12987-023-00482-9]

• N. Zhao, T. D. Chung, Z. Guo, J. J. Jamieson, L. Liang, R. M. Linville, A. F. Pessell, L. Wang, and P. C. Searson. "The influence of physiological and pathological perturbations on the blood-brain barrier," Frontiers in Neuroscience 17, 1289894 (2023). [DOI:10.3389/fnins.2023.128989]

• C. Jorgensen, E. Troendle, J. Ulmschneider, P. C. Searson, M. Ulmschneider. "A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the Blood-Brain Barrier endothelium," J Computer-Aided Molecular Design 37, 537–549 (2023). [DOI:10.1007/s10822-023-00525-1]

• P. C. Searson. "The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation," Nat Nanotechnology 18, 1121–1123 (2023). [DOI:10.1038/s41565-023-01486-0]

• N. Zhao, S. Kulkarni, S. Zhang, R. M. Linville, T. D. Chung, Z. Guo, J. J. Jamieson, D. Norman, L. Liang, A. F. Pessell, P. C. Searson. "Modeling human brain angiogenesis with a tissue-engineered venule," Angiogenesis 26, 203-216 (2023). [DOI:10.1007/s10456-023-09868-7]


2022

• L. Casciola-Rosen, D. R. Thiemann, F. Andrade, M. I. Trejo-Zambrano, E. K. Leonard, J. B. Spangler, N. E. Skinner, J. Bailey, S. Yegnasubramanian, R. Wang, A. M. Vaghasia, A. Gupta, A. L. Cox, S. C. Ray, R. M. Linville, Z. Guo, P. C. Searson, C. E. Machamer, S. Desiderio, L. M. Sauer, O. Laeyendecker, B. T. Garibaldi, L. Gao, M. Damarla, P. M. Hassoun, J. E. Hooper, C. A. Mecoli, L. Christopher-Stine, L. Gutierrez-Alamillo, Q. Yang, D. Hines, W. A. Clarke, R. E. Rothman, A. Pekosz, K. ZJ. Fenstermacher, Z. Wang, S. L. Zeger, and A. Rosen."IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function," JCI Insight 7, e158362 (2022). [DOI:10.1172/jci.insight.158362]

• Z. Guo, T. D. Chung, A. Singh, I. Pandey, X. Gu, A. Ademola, R. Linville, N. Zhao, S. Dummer, K. Nasser, U. Pal, P. C. Searson. "Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model," Advanced Science e2204395 (2022). [DOI:10.1002/advs.202204395]

• R. M. Linville, M. B. Sklar, G. N. Grifno, R. F. Nerenberg, J. Zhou, R. Ye, J. G. DeStefano, Z. Guo, R. Jha, J. J. Jamieson, N. Zhao, and Peter C. Searson. "Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels," F&BCNS 19, e87 (2022). [DOI:10.1186/s12987-022-00377-1]

• Z. Xu, N. Zahradka, S. Ip, A. Koneshloo, R. T. Roemmich, S. Sehgal, K. B. Highland, and P. C. Searson. "Evaluation of physical health status beyond daily step count using a wearable activity sensor," Nature Digital Medicine 5, e164 (2022). [DOI:10.1038/s41746-022-00696-5]

• M. A. French, R. T. Roemmich, K. Daley, M. Beier, S. Penttinen, P. Raghavan, P. Searson, S. Wegener, P. Celnik. "Precision Rehabilitation: Optimizing Function, Adding Value to Health Care," Arch Phys Med Rehabil 103, 1233-1239 (2022). [DOI:10.1016/j.apmr.2022.01.154]

• R. J. Cotton, R. L. Segal, B. A. Seamon, A. Sahu, M. M. McLeod, R. D. Davis, S. L. Ramey, M. A. French, R. T. Roemmich, K. Daley, M. Beier, S. Penttinen, P. Raghavan, P. Searson, S. Wegener, P. Celnik. "Precision Rehabilitation: Optimizing Function, Adding Value to Health Care," Arch Phys Med Rehabil 103, 1883-1884 (2022). [DOI:10.1016/j.apmr.2022.04.017]

• N. Zhao, Z. Guo, S. Kulkarni, D. Norman, S. Zhang, T. D. Chung, R. F. Nerenberg, R. Linville, P. C. Searson, "Engineering the human blood-brain barrier at the capillary scale using a double-templating technique," Adv Functional Materials 32, 2110289 (2022). [DOI:10.1002/adfm.202110289]

• J. J. Jamieson, Y.-Y. Lin, N. Malloy, D. Soto, P. C. Searson and S. Gerecht, "Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization," FASEB 36, e22331 (2022). [DOI:10.1096/fj.202200010RR]

• T. D. Chung, R. M. Linville, Z. Guo, R. Ye, R. Jha, G. N. Grifno, P. C. Searson. "Modeling effects of acute and chronic stress on blood-brain barrier function in 2D and 3D," F&BCNS 19, e33 (2022). [DOI:10.1186/s12987-022-00327-x]

• R. M. Linville, R. F. Nerenberg, G. Grifno, D. Arevalo, Z. Guo, Peter C. Searson, “Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease," F&BCNS 19, e54 (2022). [DOI:10.1186/s12987-022-00347-7]

• D. Pamies, D. Wiersma, M. E. Katt, L. Zhao, J. Burtscher, G. Harris, L. Smirnova, P. C. Searson, T. Hartung, H. T. Hogberg. "Human organotypic brain model as a tool to study chemical-induced dopaminergic neuronal toxicity," Neurobiology of Disease 169, 105719 (2022). [DOI:10.1016/j.nbd.2022.105719]

• C. Jorgensen, M. B. Ulmschneider, Peter C. Searson. "An atomistic model of solute transport across the blood-brain barrier," ACS Omega 7, 1100-1112 (2022). [DOI:10.1021/acsomega.1c05679]


2021

• R. M. Linville and P. C. Searson. "Next-generation in vitro blood-brain barrier models: benchmarking and improving phenotypic accuracy," F&BCNS 18, e56 (2021). [DOI:10.1186/s12987-021-00291-y]

• R. M. Linville, A. Komin, X. Lan, J. G. DeStefano, C. Chu, G. Liu, P. Walczak, K. Hristova, P. C. Searson. "Reversible blood-brain barrier opening utilizing the membrane peptide melittin in vitro and in vivo," Biomaterials 275, 120942 (2021). [DOI:10.1016/j.biomaterials.2021.120942]

2020

• D. H. Choi, M. Gonzales, G. B. Kitchen, D. T. Phan, P. C. Searson, "A Capacitative Sweat Rate Sensor for Continuous and Real-Time Monitoring of Sweat Loss," ACS Sensors 5, 3821-3826 (2020). [DOI:10.1021/acssensors.0c01219]

• R. M. Linville, D. Arevalo, J. C. Maressa, N. Zhao, P. C. Searson,"Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis," Microvascular Research 132, 104042 (2020). [DOI:10.1016/j.mvr.2020.104042]

• V. L. Silvestri, E. Henriet, R. M. Linville, A. D. Wong, P. C. Searson, A. J. Ewald, "A tissue-engineered 3D microvessel model reveals the dynamics of mosaic vessel formation in breast cancer," Cancer Research 80, 4288-4301 (2020). [DOI:10.1158/0008-5472.CAN-19-1564]

• A. Komin, M. I. Bogorad, R. Lin, P. C. Searson, K. Hristova, "A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action," J Controlled Release 324, 633-643 (2020). [DOI:10.1016/j.jconrel.2020.05.0304]

• R. M. Linville, J. G. DeStefano, R. F. Nerenberg, G. N. Grifno, R. Ye, E. Gallagher, P. C. Searson, "Long-Term Cryopreservation Preserves Blood-Brain Barrier Phenotype of iPSC-Derived Brain Microvascular Endothelial Cells and Three-Dimensional Microvessels," Mol. Pharmaceutics 17, 3425-3434 (2020). [DOI:10.1021/acs.molpharmaceut.0c00484]


2019

• R. M. Linville, J. G. DeStefano, M. B. Sklar, C. Chu, P. Walczak, P. C. Searson, "Modeling hyperosmotic blood-brain barrier opening within human tissue-engineered in vitro brain microvessels," J Cerebral Blood Flow & Metabolism 40, 7 (2019). [DOI:10.1177/0271678X19867980]

• M. E. Katt, L. N. Mayo, S. E. Ellis, V. Mahairaki, J. D. Rothstein, L. Cheng, and P. C. Searson, "The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model," Fluids & Barriers of the CNS 16, e20 (2019). [DOI:10.1186/s12987-019-0139-4]

• J. J. Jamieson, R. M. Linville, Y. Ding, S. Gerecht, and P. C. Searson, "Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D," Fluids & Barriers of the CNS 16, e15 (2019). [DOI:10.1186/s12987-019-0136-7]

• M. I. Bogorad*, J. G. DeStefano*, R. M. Linville*, A. D. Wong*, P. C. Searson, "Cerebrovascular plasticity: processes that lead to changes in the cerebrovascular architecture," J Cerebral Blood Flow & Metabolism 39, 1413-1432 (2019). [DOI:10.1177/0271678X19855875]

• Y. Wang, E. Gallagher, E. Troendle, D. Hu, P. C. Searson, and M. B. Ulmschneider, "An experimentally validated method to predict the blood-brain barrier permeability of small molecules using unbiased molecular dynamics simulations," Scientific Reports 9, e6117 (2019). [DOI:10.1038/s41598-019-42272-0]

• I. Jeong, D. Bychkov, and P. C. Searson, "Wearable Devices for Precision Medicine and Health State Monitoring," IEEE Trans BME 66, 1242-1258 (2019). [DOI:10.1109/TBME.2018.2871638]

• R. M. Linville, J. G. DeStefano, M. B. Sklar, Z. Xu, A. M. Farrell, M. I. Bogorad, C. Chu, P. Walczak, L. Cheng, V. Mahairaki, K. A. Whartenby, P. A. Calabresi, P. C. Searson, "Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior," Biomaterials 190-191, 24-37 (2019).
[DOI:10.1016/j.biomaterials.2018.10.023]

• A. D. Wong, L. M. Russell, M. E. Katt, and P. C. Searson, "Chemotherapeutic Drug Delivery and Quantitative Analysis of Proliferation, Apoptosis, and Migration in a Tissue-Engineered 3D Microvessel Model of the Tumor Microenvironment," ACS Biomaterials Science & Engineering 5, 633−643 (2019). [DOI:10.1021/acsbiomaterials.8b00877]


2018

• J. G. DeStefano,* J. J. Jamieson,* R. M. Linville,* and P. C. Searson, "Benchmarking in vitro tissue-engineered blood-brain barrier models," Fluids & Barriers of the CNS 15, 32 (2018). [DOI:10.1186/s12987-018-0117-2]

• E. P. Troendle, A. Khan, P. C. Searson, and M. B. Ulmschneider, "Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks," J. Controlled Release 292, 2212-234 (2018). [DOI:10.1016/j.jconrel.2018.11.010]

• N. Zahradka, I. C. Jeong, and P. C. Searson, "Distinguishing positions and movements in bed from load cell signals," Physiological Measurement 39, 125001 (2018). [DOI:10.1088/1361-6579/aaeca8]

• L. Woodard, C. Dennis, J. Borchers, A. Attaluri, E. Velarde, C. Dawidczyk, P. C. Searson, M. Pomper, and R. Ivkov, "Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality," Scientific Reports 8, 12706 (2018). [DOI:10.1038/s41598-018-29711-0]

• H-J. Jang, T. Lee, J. Song, L. Russell, H. Li, J. Dailey, P. C. Searson, H. E. Katz, "Electronic Cortisol Detection Using Antibody-Embedded Polymer Coupled to a Commercial Field-effect Transistor," Applied Materials and Interfaces 10, 16233-16237 (2018). [DOI:10.1021/acsami.7b18855]

• D. H. Choi, A. Thaxton, K. Kim, I. Jeong, G. R. Cutting, P. R. Sosnay, and P. C. Searson, "Sweat Test for Cystic Fibrosis: Wearable Sweat Sensor vs. Standard Laboratory Test," Journal of Cystic Fibrosis 17, e35-e38 (2018). [DOI:10.1016/j.jcf.2018.03.005]

• M. E. Katt, R. M. Linville, L. Mayo, Z. S. Zu, P. C. Searson, "Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation," Fluids & Barriers of the CNS 15, e7 (2018). [DOI:10.1186/s12987-018-0092-7]

• M. E. Katt, A. D. Wong, and P. C. Searson, "Dissemination from a solid tumor: examining the multiple parallel pathways," Trends in Cancer 4, 20-37 (2018). [DOI:10.1016/j.trecan.2017.12.002]

• L. M. Russell, M. Hultz, P. C. Searson, "Leakage kinetics of the liposomal chemotherapeutic agent Doxil," J. Control. Release 269, 171-176 (2018). [DOI:10.1016/j.jconrel.2017.11.007]