540.203 (E)

ENGINEERING THERMODYNAMICS (3) Frechette  Limit 115 Prereq: 110.202 and 540.202; Coreq: 030.102, 171.101 Formulation and solution of material, energy, and entropy balances with an emphasis on open systems. A systematic problem-solving approach is developed for chemical and biomolecular process-related systems. Extensive use is made of classical thermodynamic relationships and constitutive equations for one and two component systems. Applications include the analysis and design of engines, refrigerators, heat pumps, compressors, and turbines.

Lec.
Sec. 01
02

MTW 9
Th 4
F 2

540.301 (E)

KINETIC PROCESSES (4) Hanes Limit 80 65   Prereqs: 540.203, 540.303  Review of numerical methods applied to kinetic phenomena and reactor design in chemical and biological processes. Homogeneous kinetics and interpretation of reaction rate data. Batch, plug flow, and stirred tank reactor analyses, including reactors in parallel and in series. Selectivity and optimization considerations in multiple reaction systems. Non isothermal reactors. Elements of heterogeneous kinetics, including adsorption isotherms and heterogeneous catalysis. Coupled transport and chemical/biological reaction rates.

Sec. 01

MTW 11,
F 12-1:30

540.303 (E,N)

TRANSPORT PHENOMENA I (4) Stebe   Limit 145 115  Coreq: Differential Equations Introduction to the field of transport phenomena. Molecular mechanisms of momentum transport (viscous flow), energy transport (heat conduction), and mass transport (diffusion). Isothermal equations of change (continuity, motion, and energy). The development of the Navier Stokes equation. The development of non isothermal and multi component equations of change for heat and mass transfer. Exact solutions to steady state, isothermal unidirectional flow problems, to steady state heat and mass transfer problems. The analogies between heat, mass, and momentum transfer are emphasized throughout the course.

Sec. 01

MTThF 3

540.306 (E)

CHEMICAL AND BIOLOGICAL SEPARATIONS (4) Betenbaugh   Limit 80 65   Prereq: 540.303, 540.202   This course covers staged and continuous-contacting separations processes critical to the chemical and biochemical industries. Processes considered include distillation, liquid-liquid extraction, gas absorption, leaching chromatography, crystallization, precipitation, filtration, and drying.  Particular emphasis is placed on the biochemical uses of these processes and consequently on how the treatment of these processes differs from the more traditional approach.

Sec. 01

TTh 2-4, T 4-6pm, F 4

540.314 (E)

CHEMICAL ENGINEERING PRODUCT AND PROCESS DESIGN (4) Katz/Nwankwo   Limit 35 per section  Prereq: 540.311 or 540.313  This course guides the student through the contrasting aspects of product design and of process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the selection of best products to fulfill the needs. Process design concerns the quantitative description of processes, which serve to produce many commodity chemicals, the estimation of process profitability, and the potential for profitability improvement through incremental changes in the process. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the primary objectives of the course. Students report several times both orally and in writing on their accomplishments.

Sec. 01
02

TTh 9:30-12
TTh 1:30-4

540.404 (E)

THERAPEUTIC AND DIAGNOSTIC COLLOIDS (3) Hanes/Wirtz  Limit 50 30 Prereq's: 540.303, 020.306, 020.305 & coreq: 540.301 The inefficient or inappropriate transport of particles in complex biological fluids in the body currently limits the effectiveness of nanoparticle-based strategies aimed at providing a variety of breakthroughs in medicine, from highly targeted drug and gene delivery systems to improved particles for advanced imaging and diagnostics. Many bodily fluids serve as barriers to particle transport to desired locations, and some are microporous, highly viscous and/or elastic in nature. This course seeks to provide a fundamental understanding of the phenomena, including fluid micro-, meso- and macrorheology, that governs nano- and microparticle transport in important biological fluids, including the blood, airways, mucus, and living cells. A comparison of macroscopic and microscopic particle transport behavior, including comparisons of ensemble-average transport behavior to that of individual particle behavior, is a common thread that runs throughout the course. The importance of particle physicochemical properties in achieving desired particle transport through biological barriers to desired sites of action will be addressed. The course will include a case study involving the design criteria of efficient synthetic systems for gene delivery in the lung airways. Course added 11/10/06

Sec. 01

MW 4-5:15

540.406 (E)

MOLECULAR SIMULATIONS AND MULTISCALE MODELING (3)
Drazer/Gray    This course provides an introduction to modern numerical methods for calculating thermodynamics, transport and structural properties of complex systems in chemical and biomolecular engineering. The first part of the course will focus on molecular level simulations, from ab initio methods of Molecular Dynamics and Monte Carlo simulations, their applications and limitations. The second part of the ocurse will emphasize the need of multiscale models to address the multiplicity of length and time scales present in complex systems. Mesoscopic models will be investigated as a first step into multiscale models. Then, current methods to bridge the gap between atomistic simulations and macroscopic methods will be presented in case studies. Same course as 540.606 Course added 10/31/06

Sec. 01

MWF 11

540.440 (E)

MICRO & NANOTECHNOLOGY (3)
Gracias Limit 50 20 Micro/Nanotechnology is the field of fabrication, characterization and manipulation of extremely small objects (dimensions on the micron to nanometer length scale). Microscale objects, because of their small size are expected to be at the frontier of technological innovation for the next decade. This course will include a description of the materials used in microtechnology, methods employed to fabricate nanoscale objects, techniques involved in characterizing and exploiting the properties of small
structures, and examples of how this technology is revolutionizing the areas of Electronics & Medicine. Same class as 540.640 Same course as 540.640

Limit 30  Prereq: An undergraduate course in Biochemistry and/or Cell Biology.   This course provides details of the latest advances in cellular and molecular biology for mammalian systems, with special implications for biotechnology. Topics covered include tissue organization, gene expression, signal transduction, immunology, proteomics, genomics, and post-transnational processing.  Special emerging areas in biotechnology involving mammalian cells will be described including nanobiotechnology for mammalian cells, metabolic and cellular engineering, stem cell therapies, and tissue engineering.

Sec. 01

MW 5:30-6:20
Th 5-8pm

540.442 (E)

ADVANCED TOPICS IN BIOCHEMICAL KINETICS (3) Betenbaugh/ Hanes/ Ostermeier Limit 40 Survey of kinetic/reactor phenomena of high relevance to industry and cutting-edge biomolecular engineering research. Topics to be covered vary from year to year and may include: reactions with phase change for the microelectronics industry, computational modeling of complex multiple reaction systems, polymerization kinetics, enzyme kinetics (including inhibition, allostery and cooperativity), pharmocokinetics, reaction with diffusion in biological tissues, cell bioreactors, and intracellular kinetics in the context of metabolic engineering. Course added 1/19/07

 Sec. 01

      TTh 4-5:15

540.460 (E)

DESIGN OF BIOLOGICAL MOLECULES AND SYSTEMS COMPUTATIONAL AND EXPERIMENTAL DESIGN OF BIOMOLECULES (3)  Ostermeier/Gray Limit 60 30 Prerequisite: 020.305 This course reviews current research problems in biomolecular design both from computational and experimental approaches. Current methods in structure prediction (folding, docking and design) will illustrate fundamental concepts in protein structure, biophysics, and optimization. Current research problems in evolution-based biomolecular engineering will illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells.

Ostermeier/Gray  Limit 20   Prereq:  020.305 & 020.306 or permission of instructor.  Current research problems in biomolecular engineering will be used to illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells. Emphasis will be placed on experimental approaches to design (especially those approaches that employ the principles of evolution).

Sec. 01

MW 2:30-3:45

360.404 (E,N)

INTERFACIAL PHENOMENA IN NANOSTRUCTURED MATERIALS (3) Erlebacher/Stebe   Undergrad level of 360.644  Limit 15  All materials properties of materials change when encountered or fabricated with nanoscale structure. In this class, we will examine how the properties of nanostructured materials differ from their macroscopic behavior, primarily due to the presence of large interfacial areas relative to the characteristic volume scale. General topics include the structure of nanostructured materials (characterization & microscopy), thermodynamics (effects of high curvatures and surface elasticity), kinetics and phase transformations (diffusion and morphological stability), and electronic properties (quantum confinement and effects of dimensionality) Cross-listed with Materials Science and Interdepartmental

Sec. 01

TTh 1-2:15

540.502

INDEPENDENT STUDY

540.522

INDEPENDENT RESEARCH

540.601

CHEMICAL ENGINEERING  SEMINAR  Gray Limit 75 30

 Sec. 01

               Th 11

540.604 (E)

THERAPEUTIC AND DIAGNOSTIC COLLOIDS (3) Hanes/Wirtz  Limit 30 Prereq's: 540.303, 020.306, 020.305 & coreq: 540.301 The inefficient or inappropriate transport of particles in complex biological fluids in the body currently limits the effectiveness of nanoparticle-based strategies aimed at providing a variety of breakthroughs in medicine, from highly targeted drug and gene delivery systems to improved particles for advanced imaging and diagnostics. Many bodily fluids serve as barriers to particle transport to desired locations, and some are microporous, highly viscous and/or elastic in nature. This course seeks to provide a fundamental understanding of the phenomena, including fluid micro-, meso- and macrorheology, that governs nano- and microparticle transport in important biological fluids, including the blood, airways, mucus, and living cells. A comparison of macroscopic and microscopic particle transport behavior, including comparisons of ensemble-average transport behavior to that of individual particle behavior, is a common thread that runs throughout the course. The importance of particle physicochemical properties in achieving desired particle transport through biological barriers to desired sites of action will be addressed. The course will include a case study involving the design criteria of efficient synthetic systems for gene delivery in the lung airways. Same course as 540.404 Course added 11/10/06

Sec. 01

MW 4-5:15

540.606 (E)

MOLECULAR SIMULATIONS AND MULTISCALE MODELING (3)
Drazer/Gray    This course provides an introduction to modern numerical methods for calculating thermodynamics, transport and structural properties of complex systems in chemical and biomolecular engineering. The first part of the course will focus on molecular level simulations, from ab initio methods of Molecular Dynamics and Monte Carlo simulations, their applications and limitations. The second part of the ocurse will emphasize the need of multiscale models to address the multiplicity of length and time scales present in complex systems. Mesoscopic models will be investigated as a first step into multiscale models. Then, current methods to bridge the gap between atomistic simulations and macroscopic methods will be presented in case studies. Same course as 540.406 Course added 10/31/06

Sec. 01

MWF 11

360.621

NANOBIO LABORATORY Searson/Wirtz  Limit 20 15 30 Perm Req'd. This course introduces students to concepts and laboratory techniques in nanobiotechnology. The focus of the laboratory is on nanopaticle carriers for drug delivery and markers for imaging. The laboratory involves the synthesis of nano particles using solution phase techniques and characterization by optical techniques such as dynamic light scattering and absorbance spectroscopy. Strategies for funtionalization of nanoparticles are covered with focus on methods for attaching biomolecules. The basic aspects of cell culture and optical microscopy techniques will be covered. Nanoparticles functionalized with a drug or gene will be used to perform transfection experiments and compared to standard techniques.  
Cross-listed with Interdepartmental and Materials Science Course added 11/01/06 Course canceled 01/09/07

Sec. 01

F 12-4

360.644

INTERFACIAL PHENOMENA IN NANOSTRUCTURE MATERIALS
Stebe/Erlebacher  Limit 15  All materials properties of materials change when encountered or fabricated with nanoscale structure. In this class, we will examine how the properties of nanostructured materials differ from their macroscopic behavior, primarily due to the presence of large interfacial areas relative to the characteristic volume scale. General topics include the structure of nanostructured materials (characterization & microscopy), thermodynamics (effects of high curvatures and surface elasticity), kinetics and phase transformations (diffusion and morphological stability), and electronic properties (quantum confinement and effects of dimensionality).    Graduate level of  360.404  Cross-listed with Materials Science and Engineering and Interdepartmental

Sec. 01

TTh 1-2:15

540.640

MICRO & NANOTECHNOLOGY
Gracias   Limit 50 20  Micro/Nanotechnology is the field of fabrication, characterization and manipulation of extremely small objects (dimensions on the micron to nanometer length scale). Microscale objects, because of their small size are expected to be at the frontier of technological innovation for the next decade. This course will include a description of the materials used in microtechnology, methods employed to fabricate nanoscale objects, techniques involved in characterizing and exploiting the properties of small structures, and examples of how this technology is revolutionizing the areas of Electronics & Medicine. Same class as 540.440

Sec. 01

MW 5:30-6:30
Th 5-8pm

540.642

ADVANCED TOPICS IN BIOCHEMICAL KINETICS  Betenbaugh/ Hanes/ Ostermeier  Limit 15
Survey of kinetic/reactor phenomena of high relevance to industry and cutting-edge biomolecular engineering research. Topics to be covered vary from year to year and may include: reactions with phase change for the microelectronics industry, computational modeling of complex multiple reaction systems, polymerization kinetics, enzyme kinetics (including inhibition, allostery and cooperativity), pharmocokinetics, reaction with diffusion in biological tissues, cell bioreactors, and intracellular kinetics in the context of metabolic engineering.

 Sec. 01

      TTh 4-5:15

540.660

DESIGN OF BIOLOGICAL MOLECULES AND SYSTEMS COMPUTATIONAL AND EXPERIMENTAL DESIGN OF BIOMOLECULES Ostermeier/Gray Limit 20 30 Prerequisite: 020.305 This course reviews current research problems in biomolecular design both from computational and experimental approaches. Current methods in structure prediction (folding, docking and design) will illustrate fundamental concepts in protein structure, biophysics, and optimization. Current research problems in evolution-based biomolecular engineering will illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells. Graduate level of 540.460

Ostermeier/ Gray     Limit 20   Prereq:  020.305 & 020.306 or permission of instructor.  Current research problems in biomolecular engineering will be used to illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells. Emphasis will be placed on experimental approaches to design (especially those approaches that employ the principles of evolution).

Sec. 01

MW 2:30-3:45

540.801

GRADUATE RESEARCH

540.811

INDEPENDENT STUDY