540.102 (E)

INTRODUCTION TO CHEMICAL AND BIOMOLECULAR ENGINEERING PROBLEMS (1) Kermis   Limit 140    This course will introduce students to typical problems encountered by chemical and biomolecular engineers, and the tools used to address them.  Fundamental concepts in material and energy balances, thermodynamics, transport phenomena and reaction kinetics will be introduced, and will demonstrate the relevance of future chemical and biomolecular core engineering courses.  Student will also be exposed to valuable engineering skills such as: problem identification and solving, design of experiments and the analysis and interpretation of data.

Sec. 01

M 2

540.203 (E)

ENGINEERING THERMODYNAMICS (3) Frechette  Limit 115 Prereqs: 030.101, 171.101, 540.202; Coreq: 110.202 Coreq: 030.102, 171.101 Formulation and solution of material, energy, and entropy balances with an emphasis on open systems. A systematic problem-solving approach is developed for chemical and biomolecular process-related systems. Extensive use is made of classical thermodynamic relationships and constitutive equations for one and two component systems. Applications include the analysis and design of engines, refrigerators, heat pumps, compressors, and turbines.

Sec. 01

MTW 9 10

540.301 (E)

KINETIC PROCESSES (4) Hanes Limit 65   Prereqs: 540.203, 540.303      Review of numerical methods applied to kinetic phenomena and reactor design in chemical and biological processes. Homogeneous kinetics and interpretation of reaction rate data. Batch, plug flow, and stirred tank reactor analyses, including reactors in parallel and in series. Selectivity and optimization considerations in multiple reaction systems. Non isothermal reactors. Elements of heterogeneous kinetics, including adsorption isotherms and heterogeneous catalysis. Coupled transport and chemical/biological reaction rates.

Sec. 01

MTW 11 10,
F 12-1:30

540.303 (E,N)

TRANSPORT PHENOMENA I (4) Stebe   Limit 115    Coreq: Differential Equations Introduction to the field of transport phenomena. Molecular mechanisms of momentum transport (viscous flow), energy transport (heat conduction), and mass transport (diffusion). Isothermal equations of change (continuity, motion, and energy). The development of the Navier Stokes equation. The development of non isothermal and multi component equations of change for heat and mass transfer. Exact solutions to steady state, isothermal unidirectional flow problems, to steady state heat and mass transfer problems. The analogies between heat, mass, and momentum transfer are emphasized throughout the course.

Sec. 01

MTThF 3

540.306 (E)

CHEMICAL AND BIOLOGICAL SEPARATIONS (4) Park/Betenbaugh Limit 65   Prereq: 540.303, 540.202  This course covers staged and continuous-contacting separations processes critical to the chemical and biochemical industries. Processes considered include distillation, liquid-liquid extraction, gas absorption, leaching chromatography, crystallization, precipitation, filtration, and drying. Particular emphasis is placed on the biochemical uses of these processes and consequently on how the treatment of these processes differs from the more traditional approach.

Sec. 01

TF 2-4

540.314 (E)

CHEMICAL ENGINEERING PROCESS DESIGN (4) Katz   Limit 35 25 Prereq: 540.311 or 540.313  This course guides the student through the contrasting aspects of product design and of process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the selection of best products to fulfill the needs. Process design concerns the quantitative description of processes, which serve to produce many commodity chemicals, the estimation of process profitability, and the potential for profitability improvement through incremental changes in the process. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the primary objectives of the course. Students report several times both orally and in writing on their accomplishments.

Sec. 01

TTh 1:30-4

360.404 (E,N)

INTERFACIAL PHENOMENA IN NANOSTRUCTURE MATERIALS (3) Stebe,Erlebacher   Limit 100  All materials properties of materials change when encountered or fabricated with nanoscale structure. In this class, we will examine how the properties of nanostructured materials differ from their macroscopic behavior, primarily due to the presence of large interfacial areas relative to the characteristic volume scale. General topics include the structure of nanostructured materials (characterization & microscopy), thermodynamics (effects of high curvatures and surface elasticity), kinetics and phase transformations (diffusion and morphological stability), and electronic properties (quantum confinement and effects of dimensionality).

Cross listed with Materials Science and Engineering and Interdepartmental

Sec. 01

MF 1-2:30

540.426 (E)

             (W)

INTRODUCTION TO BIOMACROMOLECULES (3)  Wirtz This course introduces modern concepts of polymer physics to describe the conformation and dynamics of biological macromolecules such as filamentous actin, microtubule, and nucleic acids. We will introduce scattering techniques, micromanipulation techniques, as well as theology applied to the study of polymers for tissue engineering and drug delivery applications.

Sec. 01

MW 11-12:20

540.433 (E)

ENGINEERING ASPECTS OF DRUG DELIVERY (3) Hanes     Limit 40  Prereq:  540.301 & either 540.303 or 580.461. Otherwise permission may be given in special cases by the Instructor.  This course addresses the fundamental engineering behind the development and understanding of controlled drug delivery systems. Focus is placed on the encapsulation and delivery of therapeutic proteins and genes from polymeric devices due to their increasing prevalence and importance in pharmaceutical products. Routes of drug delivery to be covered include oral, transdermal, pulmonary, injection, and surgical implantation. Topics include biological barriers to drug delivery, drug pharmacokinetics, particle targeting via receptor-ligand interactions, intracellular transport of collodial particles and synthetic gene delivery vectors.  Same course as 540.633

Sec. 01

MW 4-5:20

540.440 (E)

MICRO TO NANOTECHNOLOGY (3) Gracias  Limit 30   Microfabrication Lab is recommended. This course will include two lectures a week and one laboratory every three weeks. The course will include a description of the materials used in microtechnology, methods employed to fabricate nanoscale objects, techniques involved in characterizing and exploiting the properties of small structures, and examples of how this technology is revolutionizing the areas of electronics and medicine. The laboratory experiments are intended to give students a hands-on experience in the fabrication of micro and nanostructures. Same course as 540.640

Prereq: 020.305 An undergraduate course in Biochemistry and/or Cell Biology   This course provides details of the latest advances in cellular and molecular biology for mammalian systems, with special implications for biotechnology. Topics covered include tissue organization, gene expression, signal transduction, immunology, proteomics, genomics, and post-transnational processing.  Special emerging areas in biotechnology involving mammalian cells will be described including nanobiotechnology for mammalian cells, metabolic and cellular engineering, stem cell therapies, and tissue engineering.

Sec. 01

MW 5:30-6:20

Th 5-8pm

540.460 (E)

DESIGN OF BIOLOGICAL MOLECULES AND SYSTEMS (3)  Ostermeier  Limit 40  Prereq:  020.305 & 020.306 or permission of instructor.  Current research problems in biomolecular engineering will be used to illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells. Emphasis will be placed on experimental approaches to design (especially those approaches that employ the principles of evolution).

Sec. 01

MW 9-10:20

540.502

INDEPENDENT STUDY

540.522

INDEPENDENT RESEARCH

540.601

CHEMICAL ENGINEERING  SEMINAR  Gray

 Sec. 01

Th 11

360.644

INTERFACIAL PHENOMENA IN NANOSTRUCTURE MATERIALS Stebe,Erlebacher  All materials properties of materials change when encountered or fabricated with nanoscale structure. In this class, we will examine how the properties of nanostructured materials differ from their macroscopic behavior, primarily due to the presence of large interfacial areas relative to the characteristic volume scale. General topics include the structure of nanostructured materials (characterization & microscopy), thermodynamics (effects of high curvatures and surface elasticity), kinetics and phase transformations (diffusion and morphological stability), and electronic properties (quantum confinement and effects of dimensionality).    Same class as 360.404  Cross listed with Materials Science and Engineering and Interdepartmental

Sec. 01

MF 1-2:30

540.626

INTRODUCTION TO BIOMACROMOLECULES  Wirtz This course introduces modern concepts of polymer physics to describe the conformation and dynamics of biological macromolecules such as filamentous actin, microtubule, and nucleic acids. We will introduce scattering techniques, micromanipulation techniques, as well as theology applied to the study of polymers for tissue engineering and drug delivery applications. Same class as 540.426

Sec. 01

MW 11-12:20

540.633

ENGINEERING ASPECTS OF DRUG DELIVERY Hanes     Prereq:  540.301 & either 540.303 or 580.461. Otherwise permission may be given in special cases by the Instructor.     Same as course as 540.433

Sec. 01

MW 4-5:20

540.640

MICRO TO NANOTECHNOLOGY Gracias Limit 30 Microfabrication Lab is recommended. This course will include two lectures a week and one laboratory every three weeks. The course will include a description of the materials used in microtechnology, methods employed to fabricate nanoscale objects, techniques involved in characterizing and exploiting the properties of small structures, and examples of how this technology is revolutionizing the areas of electronics and medicine. The laboratory experiments are intended to give students a hands-on experience in the fabrication of micro and nanostructures. Same class as 540.440

Prereq: 020.305 Micro/Nanotechnology is the field of fabrication, characterization and manipulation of extremely small objects (dimensions on the micron to nanometer length scale). Microscale objects, because of their small size are expected to be at the frontier of technological innovation for the next decade. This course will include a description of the materials used in microtechnology, methods employed to fabricate nanoscale objects, techniques involved in characterizing and exploiting the properties of small structures, and examples of how this technology is revolutionizing the areas of Electronics & Medicine.

Sec. 01

MW 5:30-6:20

Th 5-8pm

540.660

DESIGN OF BIOLOGICAL MOLECULES AND SYSTEMS Ostermeier  Prereq:  020.305 & 020.306 or permission of instructor.  Current research problems in biomolecular engineering will be used to illustrate principles in the design of biomolecules )i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells. Emphasis will be placed on experimental approaches to design (especially those approaches that employ the principles of evolution). Same class as 540.460

Sec. 01

MW 9-10:20

540.668

MOLECULAR MODELING OF BIOLOGICAL INTERACTIONS Paulaitis This course will survey quantitative analytical methods and computational approaches for modeling molecular interactions in biological systems. Topics will include electronic structure prediction, molecular simulations, molecular thermodynamic models of protein stability/interactions, n on-equlibrium statistical mechanics models of dynamics, computational mechanics of biologica macromolecules, bioinformatics approaches to structure prediction, network analysis for protein-protein and protein-DNA interactions. Course added 12/12/05

540.801

GRADUATE RESEARCH

540.811

INDEPENDENT STUDY