020.125 (H,N)

BIOLOGY IN FILM: DISCOVERY, DISEASE, AND DISASTER (1) Schroer    Satisfactory/Unsatisfactory only This course will feature weekly presentations of highly acclaimed, Hollywood films. Each film will be hosted by a different member of the Biology faculty who will provide an introduction and discussion of the film. Film topics include early discoveries in the biomedical arena, genetic and infectious diseases, and the potential consequences of human genetic engineering. Students will be expected to attend all classes and complete a questionnaire based on each film.
Cross-listed with Film & Media Studies

Sec. 01

Th 7-9:30pm

020.152 (N)

GENERAL BIOLOGY II (4) Fambrough/Shearn/McCarty/Pearlman Prereq: 020.151   Limit 340 This course builds on the concepts presented and discussed in General Biology I. The primary foci of this course will be on the diversity of life and on the anatomy, physiology, and evolution of plants and animals. There will be a special emphasis on human biology. The workshops that were introduced in 020.151 General Biology I will include the use of simulation software, a critique of the primary literature, and an exploration of current trends in medicine.

Cross-listed with Behavioral Biology

Sec. 01

MTWF 11

020.154 (N)

GENERAL BIOLOGY LAB II (1) Pearlman   Coreq: 020.152
This course reinforces the topics covered in 020.152. Laboratory exercises explore subjects ranging from evolution to anatomy and physiology. Students participate in a project using molecular biology techniques to determine whether specific foods are made from genetically engineered plants.

Cross-listed with Behavioral Biology

Lec.

Sec. 01

02

03

04

05

Th 1

M 1-4

T 1-4

W 1-4

Th 2-5

F 1-4

020.162 (N)

BIOLOGY WORKSHOP II (1) Pearlman   Prereq: Score of 4 or 5 on AP Biology exam    Limit 60 The Biology Workshop covers applications and current trends in biology, through guest lectures from researchers and hands-on computer programs.   Credit will be awarded for EITHER 020.152 or 020.162, but not both.

Sec. 01

F 11

020.306 (N)

CELL BIOLOGY (4)  Schroer/ Wendland   Prereq: 020.305   Limit 340 How the molecules of living systems are organized into organelles, cells, tissues, and organisms will be explored, as well as how the activities of all of these are orchestrated and regulated to produce “life”—a phenomenon greater than the sum of its parts. Considerable emphasis is placed on experimental approaches to answering these questions. Topics covered include biological membranes, cytoskeletal elements, cell locomotion, membrane and protein traffic, the nucleus, second messengers, signal transduction, cell growth, the cell cycle, the extracellular matrix, cell contacts and adhesion, intercellular communication, epithelial structure and function, and the cell biology of early development and organ function.

Sec. 01

M 1-2:30,

ThF 10:30-12

020.309 (N)

CELLULAR AND MOLECULAR NEUROPHYSIOLOGY (3) Fambrough Prereq: 080.304 or Perm Req=d.
This course covers all aspects of cellular neurophysiology, with particular attention to the biophysical and molecular bases of membrane physiology. Topics include the molecular basis of membrane permeability, action potentials, synaptic transmission, and neuronal modulation. Readings will includ e a text and original research literature, and computer simulations will be utilized to demonstrate key concepts.

Cross-listed with Neuroscience

Lec.

Sec. 01

MW 2-4:30 3:30

W 3:30-4:30

020.310 (N)

DEVELOPMENTAL NEUROBIOLOGY (3) Norris/Kirkwood Prereq: 080.304 or Perm. Req=d.
This is an upper-level course focused upon the cellular and molecular mechanisms underlying nervous system development. Topics include the specification of neural tissues, genesis and differentiation of individual neurons, extension of axons and axon guidance, formation of synaptic connections, maturation of neuronal circuits, and plasticity of neuronal circuits in the adult nervous system. The format of the course will be a mix of lectures and discussions of papers. Reading will include selected articles from the recent literature.

Cross-listed with Neuroscience

Sec. 01

ThF 10:30-12

020.312 (N)

INTRODUCTION TO THE HUMAN BRAIN (3 2) Hedgecock
This course explores the outstanding problem of biology: how knowledge is represented in the brain. Relating insights from cognitive psychology and systems neuroscience with formal theories of learning and memory, topics include (1) anatomical and functional relations of cerebral cortex, basal ganglia, limbic system, thalamus, cerebellum, and spinal cord; (2) cortical anatomy and physiology including laminar/columnar organization, intrinsic cortical circuit, hierarchies of cortical areas; (3) activity-dependent synaptic mechanisms; (4) functional brain imaging; (5) logicist and connectist theories of cognition; and (6) relation of mental representations and natural language.  Cross-listed with Neuroscience

Sec. 01

TTh 1

020.316 (N)

CELL BIOLOGY LAB (2) Horner Prereq: 020.306; Coreq: 020.306 Limit 60 per section First lab section meeting Feb. 1
This course will reinforce the topics presented in 020.306 Cell Biology through laboratory exercises which use visible and fluorescence microscopy to study chromosomes, cell organelles, cell surface receptors, contractile proteins, and microfilaments.

Lec.

Sec. 01

02

03

04

W 1

T 1-4

W 2-5

Th 1-4

F 1-4

020.332 (N)

PLANT BIOCHEMISTRY (2) Moudrianakis / Horner    Limit 25 Prereq: 020.305-306
This course will emphasize plant biochemistry, including fundamental physiological processes of plants, cell structure and function, light capture and photosynthesis, plant growth and development, and the metabolism of minerals and nitrogen.

Sec. 01

Th 9-10:30

020.333 (N)

ADAPTATIONS OF PLANTS TO THEIR ENVIRONMENT (2)    McCarty   Limit 30   Prereq:  020.151-152 or AP Biology credit This course is an introduction to the ecological physiology of higher plants. Plants grow in the tropics and the tundra, in extremely dry or wet situations, and even in salt water. The adaptations of plants to their environments will be discussed.

Sec. 01

ThF 10:30-11:30

020.346 (N)

IMMUNOBIOLOGY (3) Edidin Prereq: 020.305-306, 020.330
A course for upper-level undergraduates that will introduce them to immunochemistry, immunobiology, and clinical immunology. Emphasis is placed on the language, concepts, and experimental methodology of modern immunology and the application of this information to specific human diseases.

Sec. 01

MTW 11

020.349 (N)

EPIDEMICS AND PANDEMICS (2)  Schildbach    Prereq: 020.330 or Perm. Req’d.  The course will examine a dozen infectious diseases that have demonstrated a capacity for causing widespread illness and death. In lectures, the microbiology of the organisms and the pathology of the diseases they cause will be discussed.  The impact of these diseases on society will be studied using assigned readings.                Cross-listed with Public Health

Sec. 01

T 3-5

020.363 (N)

DEVELOPMENTAL BIOLOGY (3) Corces/ Van Doren    Prereq: 020.330, 020.305-306     Development of invertebrates, vertebrates and plants. The course will emphasize the experimental bases for the fundamental concepts of development.

Sec. 01

MTW 10

020.365 (N)

INTRODUCTION TO THE HUMAN SKELETON (3) Ruff   Limit 25 This course will provide a basic understanding of human skeletal biology, including bone composition and bone growth, recognition of skeletal elements, functional anatomy of different skeletal systems, comparative anatomy, and forensic anthropology (sexing and aging, body size reconstruction, bone pathology).  Lectures will be combined with hands-on experience with bone models and real bone specimens.    

Sec. 01

MW 3-4:30

020.366 (N)

HUMAN EVOLUTION (3) Teaford   Limit 25    Prereq: 020.207 or 020.379 or Perm. Req’d.     A close look at the fossil evidence for human evolution.  Topics include: introduction to taxonomy, evolutionary theory, paleoclimatology and dating techniques; Miocene hominoids; the earliest hominids; the first members of our genus; the position of the Neanderthals in our ancestry; and the origins and fate of modern humans.

Sec. 01

TTh 3-4:30

020.373

DEVELOPMENTAL BIOLOGY LAB (2) Norris   Coreq: 020.36 Limit 20 per section     This laboratory explores the development of live animals and students in each section will sometimes be required to return to lab on succeeding days to observe and record the results of their experiments.

Sec. 01

02

03

T 1-5

W 1-5

Th 1-5

020.388 (N)

APPROACHES TO DATA INTENSIVE PROBLEMS IN CANCER (3) Tan/ Thompson  Limit 18   Prereq: 020.305; strongly recommended 020.306 and a semester of math. This course will focus on the underlying concepts behind computational techniques and how they may be applied to the vast amounts of data being generated by cancer research.  Dean’s Teaching Fellowship Course http://protein.bio.jhu.edu/ADIPC

Sec. 01

TTh 2:30-4

020.402

SEMINAR: CURRENT PROGRESS IN CELLULAR AND MOLECULAR BIOLOGY  & BIOPHYSICS (3) Horner   BA/MS candidates only
This is a weekly seminar designed for graduate students enrolled in the B.A./M.S. and Ph.D. programs. The seminar involves student presentations of research and discussion of topics of current interest in the field.

Sec. 01

T 12-1:30

020.442

MENTORING IN BIOLOGY (1) Pearlman   Prereq: 020.151-152 Perm. Req’d.   Satisfactory/ Unsatisfactory only     This course provides students who have taken General Biology I and II  the opportunity to mentor new students in General Biology I and II.  Mentors collaborate with faculty on how to lead effective sessions, help student teams complete team assignments, and generally help students understand difficult concepts and principles in biology.  Mentors must have a firm command of the topics covered in biology and must meet with both faculty and students through the course of the semester.

Sec. 01

Sun 3-6pm
MT 6-9pm

020.502

INTRODUCTION TO INDEPENDENT STUDY Perm. Req=d. Freshmen or Sophomores only

020.504

INTRODUCTION TO RESEARCH Freshmen or Sophomores only
Perm. Req=d.

020.506

INTERNSHIP BIOLOGY

020.512

INDEPENDENT STUDY Perm. Req=d.
Juniors and Seniors only

020.514

RESEARCH PROBLEMS
Perm. Req=d.   Juniors and Seniors only

020.553

MENTORED RESEARCH PROGRAM IN MOLECULAR AND CELLULAR BIOLOGY Staff   BA/MS candidates only

TBA

020.609

CELLULAR AND MOLECULAR NEUROPHYSIOLOGY Fambrough Prereq: 080.304 or Perm. Req’d. Graduate Students only
This course covers all aspects of cellular neurophysiology, with particular attention to the biophysical and molecular bases of membrane physiology. Topics include the molecular basis of membrane permeability, action potentials, synaptic transmission, and neuronal modulation. Readings will include a text and original research literature, and computer simulations will be utilized to demonstrate key concepts.  

Cross-listed with Neuroscience

Lec.

Sec. 01

MW 2-4:30 3:30

W 3:30-4:30

020.610

DEVELOPMENTAL NEUROBIOLOGY Norris/Kirkwood     Prereq: 080.304
This is an upper-level course focused upon the cellular and molecular mechanisms underlying nervous system development. Topics include the specification of neural tissues, genesis and differentiation of individual neurons, extension of axons and axon guidance, formation of synaptic connections, maturation of neuronal circuits, and plasticity of neuronal circuits in the adult nervous system. The format of the course will be a mix of lectures and discussions of papers. Reading will include selected articles from the recent literature.

Cross-listed with Neuroscience

Sec. 01

ThF 10:30-12

020.612

INTRODUCTION TO THE HUMAN BRAIN Hedgecock    This course explores the outstanding problem of biology: how knowledge is represented in the brain.  Relating insights from cognitive psychology and systems neuroscience with formal theories of learning and memory. Cross-listed with Neuroscience

Sec. 01

TTh 1

020.613

BIOLOGY SCIENCE WRITING Huang  Limit 14   Perm. Req'd Biology Graduate Students only Course added 12/17/04

Sec. 01

M 9

020.637

ADVANCED DEVELOPMENTAL BIOLOGY & GENETICS Van Doren/ Spradling/ Halpern   Open to undergraduates with permission This course covers the genetic analysis of development, model developmental systems, cell determination, organization of tissues and organs, cell motility and recognition, and sexual reproduction.

Sec. 01

ThF 9-10:30

020.642

PROTEINS: STRUCTURE, FOLDING & INTERACTIONS Privalov     An advanced course devoted to understanding the physical origins and character of the energetics of protein structure, mechanisms, and cooperativity in folding and stabilization of the native protein structure, and physical determinants of macromolecular recognition and assembly. A goal of this course is to develop an understanding of energetics in terms of the interactions between protein groups and between these groups and the components of the solution phase. Protein energetics as measured by experimental approaches will be discussed in detail. The physico-chemical theories that describe quantitatively the contributions by non covalent forces (electrostatic, hydrogen bonding, van der Waals, hydrophobic) to stabilization will be developed.

Sec. 01

MW 10-11:30

020.651

RETROVIRUSES Beemon   This course will cover the retroviral life cycle, infection to viral particle assembly, endogenous retroviruses, retroviral diseases, and the use of retroviruses in gene therapy. Course added 12/17/04

Sec. 01

W 2-3:30

020.667

BIOCONJUGATE TECHNIQUES Lee
The organic chemistry of the amino acids, peptides, and the carbohydrates. Also selected topics from the inorganic chemistry of phosphorous and sulfur, and the organic chemistry of these elements will be presented.

Sec. 01

TTh 2:30-4
2-3:15

020.672

MICROCALORIMETRY OF STABILITY AND PROTEIN INTERACTIONS Friere
Graduate Students only
The thermodynamics and statistical thermodynamics of protein stability and protein/ligand interactions, and their experimental analysis by means of differential scanning calorimetry and isothermal titration calorimetry will be discussed in depth

Sec. 01

TW 10

020.674

GRADUATE BIOPHYSICAL CHEMISTRY Brand/Woodson/Lattman Prereq: 020.305-306 Limit 30
This course will provide an overview of protein and nucleic acid structure, fundamentals of thermodynamics and kinetics, ligand binding, folding and stability of macromolecules, and the principles of biophysical methods such as fluorescence spectroscopy, NMR and X-ray crystallography.  Co-listed as 250.644

Sec. 01

TW 8:30-10

020.679

ADVANCED BIOLOGICAL ELECTRON MICROSCOPY McCafferty   Limit 5 per section   Prereq: 020.395, Perm. Req’d
This course is intended to build upon the basic skills students acquired in the previous course. Students will be required to work on actual ongoing research projects.  The course will emphasize the integration and use of various light and electron microscopic techniques and their application to various research related questions. The course will be comprised primarily of a practical “hands on” component; but will also include theoretical considerations as students will read, analyze and discuss current journal articles. Course canceled 01/28/05

Lec.
Sec. 01
02

T Th 1
W 9-12
F 9-12

020.739

SEMINAR: TOPICS IN BIOCHEMISTRY Bessman

Sec. 01

Th 12:30-2
1-2:30

020.751

SEMINAR: RETROVIRUSES Beemon
This course will cover the retroviral life cycle, from infection to assembly of viral particles.  In addition, it will discuss endogenous retroviruses in the germ line,  retroviral diseases, including AIDs and cancer, and the use of retroviruses in gene therapy.  This is a seminar course and will consist mainly of student presentations and discussions.

Sec. 01

W 2-3:30

020.802

RESEARCH IN BIOLOGICAL PROBLEMS Staff
Biology Graduate students only

TBA

020.825

INTRODUCTION TO BIOLOGY RESEARCH Staff    Open to first year Biology graduate students only

TBA

020.826

INTRODUCTION TO BIOLOGY RESEARCH Staff    Open to first year Biology graduate students only

TBA