BIOMEDICAL ENGINEERING

580.111 (E,N)

BME MODELING & DESIGN (2) Haase   Limit 6 per section  BME Freshmen only (Formerly BME Design Group) Working in teams with upperclassmen this course (1) introduces biomedical engineering freshmen to an orderly method for analyzing and modeling biological systems and (2) introduces engineering principles to solve design problems that are biological, physiological, and/or medical.  Freshmen are expected to use the informational content being taught in calculus, physics and chemistry and to apply this knowledge to the solution of practical problems encountered in biomedical engineering.

Secs. 04 & 23 canceled 8/09/07

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Lab 01
02
03

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06
07
08
09
10
11
12
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Th 12
Th 8:30-10:30
Th 8:30-10:30
F 2-4 Th 8:30-10:30
Th 8:30-10:30 Th  1-3
Th 1-3
Th 1-3
Th 1-3
Th 3-5
Th 3-5
Th 3-5
Th 3-5
Th 5-7pm
Th 5-7pm
Th 5-7pm
Th 5-7pm
F 8:30-10:30
F 8:30-10:30
F 8:30-10:30
F 8:30-10:30
F 12-2
F 12-2
F 12-2
F 12-2
F 2-4
F 2-4

580.211 (E,N)

BME DESIGN GROUP (3) Allen     Limit 20  Sophomore-level version of 580.111 or Perm. Req’d

Sec. 01

Th 12

580.221 (E,N)

MOLECULES AND CELLS (4) Haase Colecraft Limit 36 35 per section  Prereq: 030.101-102, 030.104  An introduction to modern molecular and cellular biology in the context of potential biomedical engineering applications. Topics covered: reactions between molecules, including receptor-ligand and antigen-antibody specificity, protein structure, enzyme catalysis, genetic information, protein processing and secretion, cell physiology and cell functions. Advanced quantitative treatment including multi-state kinetics, Monte Carlo simulations of biochemical reactions, and transport phenomena.
Secs. 01 & 06 canceled 8/24/07

Lec.
Sec. 01
02
03
04
05
06

TTh 4-5:30pm
F 9
F 10
F 11
F 12
F 1
F 2

580.311 (E,N)

BME DESIGN GROUP (3) Allen    Limit 30  Perm. Req’d.   A two-semester course sequence where juniors and seniors work with a team leader and a group of BME freshmen and sophomores, to solve open-ended problems in biomedical engineering. Upperclassmen are expected to apply their general knowledge and experience, and their knowledge in their concentration area, to teach lower classmen and to generate the solution to practical problems encountered in biomedical engineering.

Lec.

T 6

580.321 (E,N)

STATISTICAL MECHANICS AND THERMODYNAMICS (3) Beer
Prereqs: Calculus I&II, Freshman/Sophomore Chemistry and Physics     Basic principles of statistical physics and thermodynamics with application to biological systems.  Topics include fundamental principles of thermodynamics, chemical equilibrium and thermodynamics of reactions
in solutions, and elementary statistical mechanics.

Sec. 01

MW 8:30-10 TTh 8:30-10

580.371 (E)

IDEA! (INNOVATION, DESIGN, ENGINEERING, AND APPLICATIONS (3) Thakor/Harshbarger  Limit 10 Perm. Req'd. Jr's & Sr's only. A small and selective group juniors and seniors will engage in creative exploration of design approaches, engineering principles, and applications to medical devices. In particular, we will present a case study of a revolutionary multi-finger prosthesis to illustrate exciting and novel principles of dexterous hand design, control (muscle, nerves, brain), power, cosmesis and so on. The lectures will include presentations by experts known for developing innovative technologies, managing such projects, and those who are the users of innovative technologies. Our goal is to select students with a track record of hands on skills, involvement in innovative technologies, demonstrated creativity and other critical and special talents, and challenge them with some open ended problem solving. Permission of instructor required. Course added 8/14/07 Course canceled 9/17/07

Sec. 01

Th 6-8pm

580.410

BME TEACHING PRACTICUM (2) Haase   Limit 20  Senior biomedical engineering students will assist the BME Modeling & Design course instructor in managing the laboratory component of the class.

Sec. 01

TBA

580.411 (E)

BME DESIGN GROUP (3) Allen
Limit 30 Perm. Req’d.   Senior-level version of 580.311-312.

Lec.

T 6

580.413 (E)

DESIGN TEAM - TEAM LEADER (4) Allen   Limit 30 Perm. Req’d.  A two-semester sequence where leaders direct a team of undergraduate biomedical engineering students in a series of design problems. Prior design team experience and permission of course director required.

Lec.

T 6

580.420 (E,N)

BUILD-A-GENOME (4) Bader Limit 8 Perm. Req’d.   Must understand fundamentals of DNA structure, DNA electrophoresis and analysis, Polymerase Chain Reaction (PCR) and must be either a) Experienced with molecular biology lab work or b) Adept at programming with a biological twist. In this combination lecture/laboratory "Synthetic Biology" course students will learn how to make DNA building blocks used in an international project to build the world's first synthetic eukaryotic genome, Saccharomyces cerevisiae v. 2.0. Please study the wiki www.syntheticyeast.org for more details about the project. Following a biotechnology boot-camp, students will have 24/7 access to computational and wet-lab resources and will be expected to spend 15-20 hours per week on this course. Advanced students will be expected to contribute to the computational and biotech infrastructure. Co-listed with 020.420. Course added 8/21/07

Lec.

MTW 8:30-10

580.421 (E,N)

SYSTEMS BIOENGINEERING I (4) Trayanova Yue   Prereq: 580.221 & 580.222 
Limit 28 25 per section  A quantitative, model-oriented investigation of the cardiovascular system. Topics are organized in three segments. (1) Molecular/cellular physiology, including electrical signaling and muscle contraction. (2) Systems cardiovascular physiology, emphasizing circuit-diagram analysis of hemodynamics. (3) Cardio-vascular horizons and challenges for biomedical engineers, including heart failure and its investigation/treatment by computer simulation, by gene-array analysis, by stem-cell technology, and by mechanical devices (left-ventricular assist and total-heart replacement).

Lec.
Sec. 01
02
03
04

MW 4-5:30pm
T 4-5:30pm
T 4-5:30pm
T 7-8:30pm
T 2-3:30

580.423 (N)

SYSTEMS BIOENGINEERING LAB I (2) Haase   Limit 38 per section   
Coreq: 580.421 Priority to Junior BME majors   A two-semester laboratory course in which various physiological preparations are used as examples of problems of applying technology in biological systems. The emphasis in this course is on the design of experimental measurements and on physical models of biological systems.

Sec. 01
Lab

Sec. 02
Lab

Sec. 03
Lab

Th 4
Th 9-1

Th 4 5pm
Th 1-5pm

F 9
F 10 9-1

580.429 (E,N)

SYSTEMS BIOENGINEERING III (4) (3) Bader  Limit 38 35 30 per section  Prereq: 580.221 & 580.222 or Perm. Req’d    Computational and theoretical systems biology at the cellular and molecular level.  Topics include organizational patterns of biological networks; analysis of metabolic networks, gene regulatory networks, and signal transduction networks; inference of pathway structure; and behavior of cellular and molecular circuits.

Lec.

Sec. 01

02

MW 4-5:30pm

T 2-3:30

T 4-5:30

580.439 (E,N)

MODELS OF THE NEURON (4) Young   Limit 40   Prereq: 110.301, 580.421-422 or equivalent   Single-neuron modeling, emphasizing the use of computational models as links between the properties of neurons at several levels of detail. Topics include thermodynamics of ion flow in aqueous environments, biology and biophysics of ion channels, gating, nonlinear dynamics as a way of studying the collective properties of channels in a membrane, synaptic transmission, integration of electrical activity in multi-compartment dendritic tree models, and properties of neural networks. Students will study the properties of computational models of neurons; graduate students will develop a neuron model using data from the literature.

Sec. 01

MW 8:30-10,
T 9

580.440 (E,N)

CELLULAR AND TISSUE ENGINEERING (3) Elisseef/Yarema   Limit 40  Prereq: 580.421-422  Junior, Senior, Graduate students only
Lectures provide an overview of molecular biology fundamentals, an extensivereview on extracellular matrix and basics of receptors, followed by topics on cell-cell and cell-matrix interactions at both the theoretical and experimental levels. Subsequent lectures will cover the effects of physical (shear, stress, strain), chemical (cytokins, growth factors), and electrical stimuli on cell function, emphasizing topics on gene regulation and signal transduction processes. Material on cell-cycle, apoptosis, metabolic engineering and gene therapy will also be incorporated into the course.

Sec. 01

MW 8:30-10

580.451 (E,N)

CELLULAR AND TISSUE ENGINEERING LAB (2) Haase/Wang Limit 8   Senior and Graduate students only; others Perm. Req’d.  Cell and tissue engineering is a field that relies heavily on experimental techniques. This laboratory course will consist of three six experiments that will provide students with valuable hands-on experience in cell and tissue engineering. Students will learn basic cell culture procedures and specialized techniques related to faculty expertise in cell engineering, microfluidics, gene therapy, microfabrication and cell encapsulation. Experiments include the basics of cell culture techniques, gene transfection and metabolic engineering, basics of cell-substrate interactions I, cell-substrate interactions II, and cell encapsulation and gel contraction.  Co-listed with 530.451

Sec. 01

TF 1-5pm

580.471 (E,N)

PRINCIPLES OF DESIGN OF BIOMEDICAL INSTRUMENTATION (4) Thakor  Limit 16 per section  Prereq: 520.213-214, electronics lab or 580.470   Lab Fee: $125 $100 This core design course will cover lectures and hands-on labs. The material covered will include fundamentals of biomedical sensors and instrumentation, FDA regulations, designing with electronics, biopotentials and ECG amplifier design, recording from heart, muscle, brain, etc., diagnostic and therapeutic devices (including pacemakers and defibrillators), applications in prosthetics and rehabilitation, and safety. The course includes extensive laboratory work involving circuits, electronics, sensor design and interface, and building complete biomedical instrumentation. The students will also carry out design challenge projects, individually or in teams (examples include “smart cane for blind,” “computer interface for quadriplegic”).

Lec.

Sec. 01

02

Th 4-6pm

F 9-1

F 1-5

580.495 (E,N)

MICROFABRICATION LAB (4) Andreou/Wang   Limit 4 per section Seniors only or Perm. Req’d.
This laboratory course introduces the principles used in the construction of microelectronic devices, sensors, and micromechanical structures. Students will work in the laboratory on the fabrication and testing of a device. Accompanying lecture material covers basic processing steps, design and analysis CAD tools, and national foundry services.
Co-listed with 530.495 and 520.495

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Sec. 01

02

03

04

05

Th 11

Th 1-4 5

F 5-8pm

F 8 9-12

F 1-4 5

Th 8-11

580.501

FRESHMAN-SOPHOMORE RESEARCH OR PRACTICUM IN BIOMEDICAL ENGINEERING

TBA

580.511

FRESHMAN - SOPHOMORE INDEPENDENT STUDY IN BIOMEDICAL ENGINEERING

TBA

580.531

JUNIOR - SENIOR RESEARCH OR PRACTICUM IN BIOMEDICAL ENGINEERING

TBA

580.541

JUNIOR - SENIOR INDEPENDENT STUDY IN BIOMEDICAL ENGINEERING

TBA

580.571

HONORS INSTRUMENTATION Thakor    Coreq: Enrollment in 580.471 Students enrolled jointly in 580.471 and 580.571 will not be required to take exams. Instead, students will develop a term paper and patent application and carry out a hands-on individual or team project throughout the semester and the intersession. Previous projects include design of EEG amplifier, voltage clamp and patch clamp, vision aid of blind, pacemaker/defibrillator, sleep detection and alert device, glucose sensor and regulation, temperature controller, eye movement detection and device control, ultrasound ranging and tissue properties, impedance plethysmography, lie detector, blood alcohol detector, pulse oximeter, etc.

Sec. 01

TBA

580.580

SENIOR DESIGN PROJECT  Allen Perm. Req’d.  Independent or team design project to design and evaluate a system. The design should demonstrate creative thinking and experimental skills, and must draw upon advanced topics of biomedical and traditional engineering.  Project proposals must be submitted by September 14, 2007

Sec. 01

TBA

580.601

HORIZONS IN SYSTEMS BIOENGINEERING I  Yue Limit 30 Course canceled 8/06/07

Sec. 01

MW 7-9pm

580.611

BIOMEDICAL DEVICE, DESIGN AND INNOVATION Allen  Limit 6 MSE students only Perm req'd. Course added 8/28/07

Sec. 01

TBA

580.628

TOPICS IN SYSTEM NEUROSCIENCE Wang, X./Zhang, K. Limit 10 Prereq: Intro. to Neuroscience, 110.302, 520.214, 580.421 or equivalent This course consists of weekly discussions of current literature in systems neuroscience. The selected readings will focus on neural mechanisms for perception, attention, motor behavior, learning, and memory, as studied using physiological, psychophysical, computational, and imaging techniques. Students are expected to give presentations and participate in discussions.

Sec. 01

W T 5

580.639

MODELS OF THE NEURON Young  Limit 12  Prereq: 110.301-302, 580.421-422 or equivalent.  See description for 580.439.

Sec. 01

MW 8:30-10
T 9

580.640

CELLULAR AND TISSUE ENGINEERING   Yarema   Limit 10  See 580.440 for full description.

Sec. 01

MW 8:30-10

580.687

FOUNDATIONS OF COMP. BIO AND BIOINFORMATICS I  Sun 

Sec. 01

T 3:30-5
F 2-3:30

580.701

SENSORIMOTOR SYSTEMS Shadmehr    Limit 20 
Course added 10/2/07

Sec. 01

Th 12

580.703

SEMINAR IN NEUROENGINEERING Thakor    Limit 20  Weekly seminar in which faculty, staff, graduate students, and outside speakers discuss topics of current research interest in the area of neuroengineering.

Sec. 01

Th 2

580.771

PRINCIPLES OF BME INSTRUMENTATION  Thakor  Limit 16 Lab Fee: $125 Graduate students only

Sec. 01

Th 4-6pm

F 6-9pm

580.801

RESEARCH IN BIOMEDICAL ENGINEERING
Graduate Students only

TBA