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Sponsored Research At The Lab Current Proposals Pending Proposals
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| 5T32EB003383 (Thakor) | 5/1/04 – 4/30/09 | 0% |
| NIH/NIBIB | $435,518 |
Predoctoral Training Grant in the field of Neuroengineering. Training and research support for 9 doctoral students per year. Project involves 20 faculty from BME, Electrical Engineering, Neurology, Neurosurgery, and Radiology.
| 1 RO1 HL71568 (Thakor) | 8/1/03 – 7/31/08 | 25% |
| NIH/NHLBI | $278,000 |
This is a study into the basic mechanisms of ischemic brain injury. The goal is to use quantitative EEG analysis, neural spike data analysis to determine the different stages of ischemic injury, and explore the mechanisms involving excitotoxicity.
| (Thakor) | 9/1/06 – 8/31/09 | 8% |
| NSF | $113,918 |
This is a collaboration with UCSD colleagues. We propose a novel imaging system for
obtaining dynamics of microvessels in brain. We will image using laser speckle technique
and then carry out image processing to extrace microvessel architectural details and
create mosaic.
see proposal
| (Anderson) | 10/1/05 – 6/30/09 | 25% |
| APL/DARPA | $338,450 |
Our goal is to develop novel hardware and signal processing techniques for brain-computer
interfaces and to create a non-invasive control platform integrated with haptic feedback and
intelligent local prosthetic control.
see proposal
| 1R21 MH074703 (Thakor) | 4/1/06-03/31/08 | 8% |
| NIH | $125,000 |
Our goal is to design and develop a microbattery, a power harvesting circuit and
integrate it with telemetry circuit and a potentiostat for neurochemical recording from
brain.
see proposal
| R21NS054146 (Thakor) | 01/18/06 – 12/30/07 | 16% |
| NIH | $125,000 |
Our goal is to discover the mechanism of neuroprotection provided by hypothermic therapy following cardiac arrest and resuscitation. We will record as well as analyze EEG signals as well as neuronal spike activity during and after cardiac arrest and hypothermia.
| R43NS046177 (Geocadin) | 1/1/06 – 6/30/07 | 8% |
| NIH/SBIR (sub-contract from IBT) | $54,011 |
This project continues our work in Phase I on a model of traumatic brain injury. In Phase I, traumatic brain injury inflicted by intracranial pressure increase in animal models was detected by evoked potential monitoring. Further traumatic brain injury experiments will be carried out intraoperative and neurocritical care settings.
| R44DK057343 (Thakor) | 01/01/06 – 10/31/06 | 12.5% |
| NIH/SBIR {sub-contract from IBT) | $110,000 |
This subcontract deals with designing microelectromechanical system, or MEMS, for
controlling fluid flow in small catheter or fluidic system. Envisaged application are
fluidic control of urine in a urethral catheter and microfludic device for microdialysis.
see INCOPRO proposal
see microdialysis proposal
| (Geocadin) | 9/1/06 – 8/31/09 | 3% |
| NIH/SBIR {sub-contract from IBT) | $235,189 |
Our goal is to develop algorithms for analyzing brain waves, namely EEG, in patients who may have receive brain injury following cardiac arrest. We also propose to monitor patients who may have received hypothermic treatment. Our group will analyze the EEG activity while the Neurology group will carry out clinical studies and patient outcome assessment.
PENDING
| (Thakor) | 1/1/07 – 12/31/08 | 8% |
| NIH | $150,000 |
The goal is to develop a microfabricated device for culturing neurons and carrying out genetic modifications.
| 1R21CA129114 (Thakor, Brem) | 7/1/07 – 6/30/09 | 8% |
| NIH | $135,468 |
We have developed a novel laser speckle imaging technique for microvessel imaging in vivo. We now propose improved imaging technology development and in collaboration with neurosurgery colleagues, we will image brain tumor vascular angiogenesis.
| 1R21NS059657-01 (Thakor, Schieber) | 7/1/07 – 6/30/09 | 8% |
| NIH | $150,000 |
Future development of direct neural control of upper limb prosthesis will require recording from a population of neurons and decoding their limb control signals. We propose novel maximum likelihood estimation techniques to decode the neural population signals and utilize these signals for actuation of hand and finger motion in prostheses.