Publications

Espenshade, PJ on PubMed

  • Lee CSY, Yeh TL, Hughes BT, Espenshade PJ. 2011. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol. Cell In press.
  • Espenshade PJ. (In Press) Cholesterol Synthesis and Regulation. In: W.J. Lennarz and M.D. Lane (eds.) The Encyclopedia of Biological Chemistry, Elsevier Inc., Oxford.
  • Burg JS, Espenshade PJ. 2011. Regulation of HMG-CoA reductase in mammals and yeast. Prog. Lipid Res. 50:403–410.
  • Burg JS, Espenshade PJ. 2011. Glucose controls phosphoregulation of HMG-COA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast. J. Biol. Chem. 286:27139-46.
  • Yeh TL, Lee CSY, Amzel LM, Espenshade PJ*, and Bianchet MB*. 2011. The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor. Structure 19:503-14. *Corresponding author.
  • Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. 2011. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol. Cell 42:160-171.
  • Porter JR, Burg JS, Espenshade PJ*, Iglesias PA*. 2010. Ergosterol regulates SREBP cleavage in fission yeast. J. Biol. Chem. 285:41051-61. *Corresponding author.
  • Bien CM and Espenshade PJ. 2010. SREBP in fungi - Hypoxic transcription factors linked to pathogenesis. Eukaryotic Cell. 9:352-9.
  • Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, and Espenshade PJ. 2009. C. neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol. Microbiol. 74:672-690.
  • Chang YC, Ingavale SS, Bien C, Espenshade PJ, and Kwon-Chung KJ. 2009. Conservation of the SREBP pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot Cell. 8:1770-1779.
  • Lee, C.Y., Stewart, E.V., Hughes, B.T. and Espenshade, P.J. 2009. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J. 28:135-43. [pdf]
  • Burg, J.S., Powel,l D.W., Chai,R., Hughes, A.L., Link, A.J. and Espenshade, P.J. 2008. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metabolism 8:522-31. [pdf]
  • Hughes, A.L., Stewart, E.V. and Espenshade, P.J. 2008. Identification of 23 mutations in fission yeast Scap that constitutively activate SREBP. J. Lipid Research 49:2001-2012. [pdf]
  • Hughes, B.T. and Espenshade, P.J. 2008. Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J. 27:1491-1501. [pdf]
  • Sehgal, A, Hughes, B.T., Espenshade, P.J. 2008. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Research 36:2024-2031. [pdf]
  • Sehgal, A., C.Y. Lee, P.J. Espenshade. 2007. SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast. PLoS Genet. 3:1389-1396. [pdf].
  • Espenshade, P.J., A.L. Hughes. 2007. Regulation of sterol synthesis in eukaryotes. Annu. Rev. Genet. 41:401-427. [pdf].
  • Lee, H., C.M. Bien, A.L. Hughes, P.J. Espenshade, K.J. Kwon-Chung. 2007. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Mol. Microbiol. 65:1018-1033. [pdf]
  • Hughes, A.L., C.Y. Lee, C.M. Bien, P.J. Espenshade. 2007. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. J. Biol. Chem. 282:24388-96. [pdf]
  • Chang, Y.C., C.M. Bien, H. Lee, P.J. Espenshade, K.J. Kwon-Chung. 2007. Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Mol. Microbiol. 64:614-29. [pdf]
  • Hughes, A.L., D.W. Powell, M. Bard, J. Eckstein, R. Barbuch, A.J. Link, and P.J. Espenshade. 2007. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metabolism 5:143-149. [pdf]
  • Todd, B.L., E.V. Stewart, J.S. Burg, A.L. Hughes, P.J. Espenshade. 2006. SREBP is a principal regulator of anaerobic gene expression in fission yeast. Mol. Cell. Biol. 26:2817-2831. [pdf]
  • Espenshade, P.J. SREBPs: sterol-regulated transcription factors. 2006. J. Cell Sci. 119:973-976. [pdf]
  • Hughes, A.L., B.L. Todd, and P.J. Espenshade. 2005. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120:831-842. [pdf]
  • Espenshade, P.J., J.L. Goldstein, and M.S. Brown. 2003. “SREBPs: Gene Regulation through Controlled Protein Trafficking”. In Handbook of Cellular Signaling (R. Bradshaw and E. Dennis, eds.). Academic Press, San Diego.
  • Espenshade, P.J., W.P. Li, D. Yabe. 2002. Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. PNAS 99:11694-11699. [pdf]
  • Yang, T., P.J. Espenshade, M.E. Wright, D. Yabe, Y. Gong, R. Aebersold, J.L. Goldstein, and M.S. Brown. 2002. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in the ER. Cell 110:489-500. [pdf]
  • Nohturfft, A., D. Yabe, J.L. Goldstein, M.S. Brown, and P.J. Espenshade. 2000. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell 102:315-323. [pdf]
  • DeBose-Boyd R.A., M.S. Brown, W.P. Li, A. Nohturfft, J.L. Goldstein, P.J. Espenshade. 1999. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99:703-712. [pdf]
  • Espenshade, P.J., D. Cheng, J.L. Goldstein, and M.S. Brown. 1999. Autocatalytic processing of Site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. J. Biol. Chem. 274:22795-22804. [pdf]
  • Cheng, D., P.J. Espenshade, C.A. Slaughter, M.S. Brown, and J.L. Goldstein. 1999. Secreted Site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory-element binding proteins. J. Biol. Chem. 274:22805-22812. [pdf]
  • Roberg, K.J., M. Crotwell, P. Espenshade, R. Gimeno, and C.A. Kaiser. 1999. LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the ER. J. Cell Biol. 145:659-672. [pdf]
  • Sakai, J., R.B. Rawson, P. Espenshade, D. Cheng, A.C. Seegmiller, J.L. Goldstein, and M.S. Brown. 1998. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell. 2:505-514. [pdf]
  • Shaywitz, D.A., P. Espenshade, R.E. Gimeno, and C.A. Kaiser. 1997. COPII subunit interactions in the assembly of the vesicle coat. J. Biol. Chem. 272:25413-25416. [pdf]
  • *Gimeno, R.E., *P. Espenshade, and C.A. Kaiser. 1996. COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p. Mol. Biol. Cell 7:1815-1823. *These authors contributed equally to the experiments in this paper. [pdf]
  • Espenshade, P., R.E. Gimeno, E. Holzmacher, P. Teung, and C.A. Kaiser. 1995. Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. J. Cell Biol. 131:311-324. [pdf]
  • R.E. Gimeno, P. Espenshade, and C.A. Kaiser. 1995. SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation. J. Cell Biol. 131:325-338. [pdf]
  • Berberich, S., N. Hyde-DeRuyscher, P. Espenshade, and M. Cole. 1992. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. Oncogene 7:775-779.