Modern biophysical and biochemical research involves applying quantitative analysis and instrumentation to complex problems in Biology. Training biophysicists and biologists to tackle these problems using a quantitative framework is a major component of the graduate program in Cell, Molecular, Developmental Biology, and Biophysics, with roughly 25 faculty actively engaged in biophysical and biochemical research. This research is supported by facilities on the Homewood campus housing state-of-the-art instrumentation for x-ray crystallography, NMR, molecular hydrodynamics, fluorescence spectroscopy, and biocalorimety. Research in biophysics in CMDB includes studies of protein and nucleic acid structure, analysis of macromolecular interactions including protein-ligand, protein-protein and protein-nucleic acid interactions, studies of RNA and protein folding, and structure-based drug design.

Faculty

Douglas Barrick Associate Professor, Department of Biophysics Determination of an atomic-level description of structure and function in proteins. Gregory Bowman Assistant Professor, Department of Biophysics Chromatin structure and nucleosome remodeling. Ludwig Brand Professor, Department of Biology Mechanisms and control of protein structure and function with emphasis on the use of fluorescence techniques. Richard Cone Professor, Department of Biophysics Mucosal immune protection; contraception. David E. Draper Professor, Department of Chemistry RNA folding, RNA-Protein interactions, ribosome assembly and function. Karen Fleming Assistant Professor, Department of Biophysics Structure, energetics and folding of membrane proteins. Ernesto Freire Professor, Department of Biology Structure-Based Thermodynamics of Molecular Recognition and Function. Bertrand Garcia-Moreno Associate Professor, Department of Biophysics Biophysical chemistry of regulatory interactions in proteins, nucleic acids, and their assemblies. Blake Hill Associate Professor, Department of Biology Protein design, protein folding and structure; NMR spectroscopy. Juliette Lecomte Professor, Department of Biophysics NMR Spectroscopy and Protein Structure. Evangelos Moudrianakis Professor, Department of Biology Assembly and dynamics of nucleoproteins and chromosomes; bioenergetics of extremophiles. Peter Privalov Professor, Department of Biology Energetics of protein structure and mechanism of protein folding and stabilization; microcalorimetry. George Rose Professor of Biophysics Protein and RNA folding. Joel Schildbach Professor, Department of Biology Structural biology of bacterial conjugation. Robert Schleif Professor, Department of Biology Mechanisms of regulation of protein and gene activity. Sarah Woodson Professor, Department of Biophysics Determination of three dimensional folding of RNA.

Johns Hopkins University
3400 N. Charles St.
Baltimore, MD 21218

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