RESEARCH IMAGES
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Image 1. Drosophila embryonic musculature marked
by MHC-tauGFP. MHC: myosin heavy chain
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Image 2. Schematic of Drosophila myoblast fusion.
Muscle founder cell attracts fusion competent myoblasts (FCMs)
and fuse with them to form multinucleated muscle fibers. |
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Image 3. Wild-type (left) and loner mutant
(right) embryos labeled with anti-MHC antibody.
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Image 4. 3D representation of an invasive F-actin
focus (middle). Horizontal confocal section reveals its invasion
into the apposing founder cell (left); and vertical section
reveals rings of cell adhesion molecules (Duf and Sns) enclosing
the F-actin focus. The F-actin focus and the cell adhesion
molecule Sns compose of a podosome-like structure (PLS)
at the protruding tip of the FCM.
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Image 5. Electron micrograph showing an invasive
FCM (pseudo colored light purple) projecting finger-like
protrusions into the apposing founder cell.
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Image 6. Cellular events during myoblast fusion.
The engagement of cell adhesion molecules induces the formation
of asymmetric F-actin-enriched structures -- a dense actin focus
in the FCM and a thin sheath of actin underlying the apposing
founder cell membrane. The F-actin propelled invasion into the
founder cell leads to tightly apposed cell membranes and the
subsequent formation of a single-channel fusion pore.
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