Simulation of Cell-Substrate and Cell-Cell Interactions in Shear Flow:
We, in collaboration with Dr. C.D.
Eggleton (University of Maryland, Baltimore County), have developed the first 3-D computational model based on immersed boundary
method to predict receptor-mediated rolling and adhesion of deformable cells in
shear flow coupled to a Monte Carlo method simulating the stochastic receptor-ligand
interactions. Ongoing studies aim at simulating cell-cell interactions in bulk suspensions.
Select Publications:
S. Jadhav, C.D. Eggleton, and
K. Konstantopoulos, "Mathematical Modeling of Cell Adhesion in Shear Flow Pertinent to Inflammation and Cancer Metastasis",
Current Pharmaceutical Design 13(15); 1511-1526, 2007.
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S. Jadhav, K.Y. Chan,
K. Konstantopoulos, C.D. Eggleton, "Shear-Induced Modulation of Intercellular Contact Area Between Two Deformable Cells Colliding Under Flow",
Journal of Biomechanics 40; 2891-2897, 2007.
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S. Jadhav, C.D. Eggleton, and
K. Konstantopoulos, “A 3D Computational
Model Predicts that Cell Deformation Affects Receptor-Ligand Bond Lifetime and
the Number of Bonds During Rolling Under Shear”.
Biophys J.
88(1); 96-104, 2005.
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