Our research is focused on employing engineering fundamentals to study basic questions in stem cell biology and applying these for tissue repair and regeneration.
Specifically, we study the interactions between stem cells (SCs) and their microenvironment with the long term goal to engineer artificial SC microenvironments capable of guiding vascular differentiation, delivery and regeneration. Our research program is based on the integrated and advanced use of tissue engineering system components and is grounded in fundamentals of interfacial science and engineering and SC biology.
- Gerecht-Nir S, Dazard J-E, Golan-Mashiach M, Osenberg S, Botvinnik A, Amariglio N, Domany E, Rechavi G, Givol D and Itskovitz-Eldor J. Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. Dev Dyn 2005; 232:488-498.
- Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R, and Vunjak-Novakovic G. Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2007; 104:11298-11303.
- Gerecht S*, Bettinger* CJ, Zhang Z, Borenstein J, Vunjak-Novakovic G, Langer R. The effect of actin disrupting agents on contact guidance of human embryonic stem cells. Biomaterials. 2007; 28:4068-4077.
- Figallo E*, Cannizzaro C*, Gerecht S*,Burdick JA, Langer R, Elvassor N, Vunjak-Novakovic G. Microbioreactor arrays for controlling cellular microenvironments. Lab Chip. Special issue on Cell and Tissue Engineering in Microsystems. 2007; 7: 710 - 719
- Gerecht S, Townsend SA, Pressler H, Zhu H, Nijst C.L.E, Broggeman J, Nichol J, Langer R. A porous photocurable bioelastomer for cell encapsulation and culture. Biomaterials. doi:10.1016/j.biomaterials.2007.07.039.