Michael Betenbaugh

Professor
Chair of Engineering for Professionals (ChemBE)

Phone: 410-516-5461
Office: MD 222
Email: beten@jhu.edu

Education

• Ph.D., Chemical Engineering. University of Delaware. 1988
• B.S., Chemical Engineering. University of Virginia. 1981

Research Interests

Our lab focuses on areas related to cellular, metabolic and biochemical engineering. The goal is to optimize cell lines to produce high quality and quantity of proteins of biopharmaceutical interest.

The CELL CYCLE ENGINEERING group focuses on cell cycle and the inhibition of programmed cell death (apoptosis) using combinatorial genetic strategies. By blocking certain metabolic pathways which initiate the apoptosis program, we have been able to delay cell death in model bioreactor environments and have shown increased protein production.

The GLYCO-ENGINEERING group focuses on the metabolic engineering of insect cells to produce glycoproteins with profiles similar to mammalian cells, thereby making it an ideal host for production of therapeutics and antibodies.

Experience

• Professor of Chemical and Biomolecular Engineering, The Johns Hopkins University. 1999 - Present
• Chair of Department of Chemical and Biomolecular Engineering, Johns Hopkins University. July 01, 2002 - July 01, 2005
• Visiting Scientist, Kyoto Institute of Technology. 2001
• Associate Professor of Chemical Engineering, The Johns Hopkins University. 1995 - 1999
• Assistant Professor of Chemical Engineering, The Johns Hopkins University. 1988 - 1995
• U.S. Army Medical Res., Inst. of Infect. Diseases, Ft. Detrick, Frederick, Maryland. 1993
• Summer Research Scientist. 1991
• Graduate Research Assistant, Department of Chemical Engineering, University of Delaware. 1983 - 1987
• Engineering Analyst, Oil Trading and Supply, Texaco, Inc.. 1981 - 1983