Whiting School of Engineering

The Department of Chemical and Biomolecular Engineering


Marc Ostermeier

Professor and Vice Chair

Phone:  410-516-7144
Office: MD 119
Email: osterm@jhu.edu
Curriculum Vitae


  • Ph.D., Chemical Engineering, University of Texas at Austin. 1996
  • B.S., Chemical Engineering, University of Wisconsin-Madison. 1990

Research Interests

Evolution is nature’s design algorithm.  We seek to understand nature’s principles of evolution and to apply these principles for the engineering of novel proteins, gene circuits, and cells.  Our protein engineering work focuses on the creation of protein switches with user-defined, regulatable functions with an eye toward engineering biological tools, biosensors, and selective therapeutic proteins. 


  • Chaikind, B., K. P. Kilambi, J. J. Gray, and M. Ostermeier. (2012) "Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers." PLoS One 7(9), e44852.
  • Wright, C. M., R. C. Wright, J. R. Eshleman, and M. Ostermeier. (2011) "A protein therapeutic modality founded on molecular regulation." Proc. Nat. Acad. Sci. USA 108, 16206-16211.
  • Heins, R. A., J. H. Choi, T. Sohka, and M. Ostermeier. (2011) "In vitro recombination of non-homologous genes can result in gene fusions that confer a switching phenotype to cells." PLoS One 6(11), e27302.
  • Sohka, T., R. A. Heins, R. M. Phelan, J. M. Greisler, C. A. Townsend and M. Ostermeier. (2009) "An externally-tunable bacterial band-pass filter." Proc. Nat. Acad. Sci. USA 106, 10135-10140.
  • Guntas, G., T. J. Mansell, J. R. Kim, and M. Ostermeier. (2005) "Directed evolution of protein switches and their application to the creation of ligand-binding proteins." Proc. Nat. Acad. Sci. USA 102, 11224-11229.