Publications

  1. Majors BS, Chiang GG, Betenbaugh MJ. Protein and Genome Evolution in MammalianCells for Biotechnology Applications. Mol Biotechnol. 2009 Apr 15.
  2. Jones MB, Rosenberg JN, Betenbaugh MJ, Krag SS. Structure and synthesis ofpolyisoprenoids used in N-glycosylation across the three domains of life. BiochimBiophys Acta. 2009 Apr 3.
  3. Nivitchanyong T, Tsai YC, Betenbaugh MJ, Oyler GA. An improved in vitro and invivo Sindbis virus expression system through host and virus engineering. VirusRes. 2009 Apr;141(1):1-12.
  4. Dorai H, Kyung YS, Ellis D, Kinney C, Lin C, Jan D, Moore G, Betenbaugh MJ.Expression of anti-apoptosis genes alters lactate metabolism of Chinese HamsterOvary cells in culture. Biotechnol Bioeng. 2009 Jan 22.
  5. Majors BS, Arden N, Oyler GA, Chiang GG, Pederson NE, Betenbaugh MJ. E2F-1overexpression increases viable cell density in batch cultures of Chinese hamsterovary cells. J Biotechnol. 2008 Nov 25;138(3-4):103-6.
  6. Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG. Enhancement of transientgene expression and culture viability using Chinese hamster ovary cellsoverexpressing Bcl-x(L). Biotechnol Bioeng. 2008 Oct 15;101(3):567-78.
  7. Rosenberg JN, Oyler GA, Wilkinson L, Betenbaugh MJ. A green light forengineered algae: redirecting metabolism to fuel a biotechnology revolution. CurrOpin Biotechnol. 2008 Oct;19(5):430-6. Epub 2008 Sep 6. Review.
  8. Zustiak MP, Pollack JK, Marten MR, Betenbaugh MJ. Feast or famine: autophagycontrol and engineering in eukaryotic cell culture. Curr Opin Biotechnol. 2008Oct;19(5):518-26. Epub 2008 Sep 16. Review.
  9. Hancock K, Narang S, Pattabhi S, Yushak ML, Khan A, Lin SC, Plemons R,Betenbaugh MJ, Tsang VC. False positive reactivity of recombinant, diagnostic,glycoproteins produced in High Five insect cells: effect of glycosylation. JImmunol Methods. 2008 Jan 31;330(1-2):130-6.
  10. Nivitchanyong T, Martinez A, Ishaque A, Murphy JE, Konstantinov K, BetenbaughMJ, Thrift J. Anti-apoptotic genes Aven and E1B-19K enhance performance of BHKcells engineered to express recombinant factor VIII in batch and low perfusioncell culture. Biotechnol Bioeng. 2007 Nov 1;98(4):825-41.
  11. Figueroa B Jr, Ailor E, Osborne D, Hardwick JM, Reff M, Betenbaugh MJ.Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19Kand Aven in the production of a monoclonal antibody with Chinese hamster ovarycells. Biotechnol Bioeng. 2007 Jul 1;97(4):877-92.
  12. Majors BS, Betenbaugh MJ, Chiang GG. Links between metabolism and apoptosisin mammalian cells: applications for anti-apoptosis engineering. Metab Eng. 2007 Jul;9(4):317-26. Epub 2007 May 23. Review.
  13. Arden N, Majors BS, Ahn SH, Oyler G, Betenbaugh MJ. Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures. Biotechnol Bioeng. 2007 Jun15;97(3):601-14.
  14. Arden N, Ahn SH, Vaz W, Rhodes M, Hancock C, Abitorabi MA, Betenbaugh MJ.Chemical caspase inhibitors enhance cell culture viabilities and protein titer.Biotechnol Prog. 2007 Mar-Apr;23(2):506-11.
  15. Tomiya N, Narang S, Park J, Abdul-Rahman B, Choi O, Singh S, Hiratake J,Sakata K, Betenbaugh MJ, Palter KB, Lee YC. Purification, characterization, andcloning of a Spodoptera frugiperda Sf9 beta-N-acetylhexosaminidase thathydrolyzes terminal N-acetylglucosamine on the N-glycan core. J Biol Chem. 2006Jul 14;281(28):19545-60. Epub 2006 May 9.
  16. Viswanathan K, Tomiya N, Park J, Singh S, Lee YC, Palter K, Betenbaugh MJ.Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase.Differential localization of the Drosophila and human enzymes. J Biol Chem. 2006 Jun 9;281(23):15929-40. Epub 2006 Mar 14.
  17. Sauerwald TM, Figueroa B Jr, Hardwick JM, Oyler GA, Betenbaugh MJ. Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell deathin mammalian cell cultures. Biotechnol Bioeng. 2006 Jun 5;94(2):362-72.
  18. Arden N, Betenbaugh MJ. Regulating apoptosis in mammalian cell cultures.Cytotechnology. 2006 Mar;50(1-3):77-92. Epub 2006 Jul 1.
  19. Krambeck FJ, Betenbaugh MJ. A mathematical model of N-linked glycosylation.Biotechnol Bioeng. 2005 Dec 20;92(6):711-28.
  20. Kim YK, Shin HS, Tomiya N, Lee YC, Betenbaugh MJ, Cha HJ. Production andN-glycan analysis of secreted human erythropoietin glycoprotein in stablytransfected Drosophila S2 cells. Biotechnol Bioeng. 2005 Nov 20;92(4):452-61.

 

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