The Greenberg group addresses problems at the interface of chemistry and biology that focus on the structure, reactivity, and function of nucleic acids. As the carrier of genetic information, understanding the chemistry of DNA is extremely important. In addition, understanding the chemistry of RNA is becoming increasingly important with respect to understanding the folding of this macromolecule and its role in disease. In order to solve problems we use organic chemistry, biochemistry, and molecular biology.

The investigations carried out in our group are designed to answer fundamental problems concerning nucleic acid chemistry and to develop tools that are useful in biotechnology.

 

Our studies on nucleic acids are divided into the following principal areas.