Search PubMed
SELECTED PUBLICATIONS (2000
- present)
C. Kut, F. Mac Gabhann, A.S. Popel. Where is VEGF in the body? A
meta-analysis of VEGF distribution in cancer. Br. J. Cancer. 97:
978-985, 2007. [Abstract],
[Full Text (pdf)], [Supplement
(pdf)]
Z. Liao, S. Feng, A.S. Popel, W.E. Brownell, A.A. Spector. Outer hair
cell active force generation in the cochlear environment. J. Acoust. Soc.
Am. 122: 2215-2225, 2007. [Abstract],
[Full Text
(pdf)]
J.W. Ji, F. Mac Gabhann, A.S. Popel. Skeletal Muscle VEGF Gradients in
Peripheral Arterial Disease: Simulations of Rest and Exercise. Am. J.
Physiol. Heart Circ. Physiol. [Epub ahead of print], 2007. [Abstract],
[Full Text (pdf)]
J. Zhang, P.C. Johnson, A.S. Popel. Red blood cell aggregation and
dissociation in shear flows simulated by lattice Boltzmann method. J.
Biomech. [Epub ahead of print], 2007. [Abstract],
[Full Text (pdf)]
P. Vempati, E.D. Karagiannis, A.S. Popel. A biochemical model of the
matrix metalloproteinase 9 activation and inhibition. J. Biol. Chem. [Epub
ahead of print], 2007. [Abstract],
[Full Text (pdf)]
S. Hazarika, A.O. Dokun, Y. Li, A.S. Popel, C.D. Kontos, B.H. Annex.
Impaired Angiogenesis Following Hindlimb Ischemia in Type 2 Diabetes Mellitus.
Differential Regulation of Vascular Endothelial Growth Factor Receptor 1 and
Soluble VEGFR-1. Circ. Res. [Epub ahead of print], 2007. [Abstract],
[Full Text (pdf)]
A.A. Qutub, A.S. Popel. Three autocrine feedback loops determine
HIF1alpha expression in chronic hypoxia. Biochim. Biophys. Acta. [Epub
ahead of print], 2007. [Abstract],
[Full Text (pdf)]
E.D. Karagiannis, A.S. Popel. Peptides derived from type I
thrombospondin repeat-containing proteins of the CCN family inhibit
proliferation and migration of endothelial cells. Int. J. Biochem. Cell.
Biol. 39: 2314-2323, 2007. [Abstract],
[Full Text (pdf)]
N.M. Tsoukias, D. Goldman, A. Vadapalli, R.N. Pittman, A.S. Popel. A
computational model of oxygen delivery by hemoglobin-based oxygen carriers in
three-dimensional microvascular networks. J. Theor. Biol. 248:
657-674, 2007. [Abstract],
[Full Text (pdf)]
S. Kim, J. Zhen, A.S. Popel, M. Intaglietta, P.C. Johnson. Contributions
of collision rate and collision efficiency to erythrocyte aggregation in
postcapillary venules at low flow rates. Am. J. Physiol. Heart Circ.
Physiol. [Abstract],
[Full Text (pdf)]
K. Chen, R.N. Pittman, A.S. Popel. Vascular Smooth
Muscle NO Exposure from Intraerythrocytic SNOHb: A Mathematical Model.
Antioxid Redox Signal
Antioxid. Redox. Signal.
9: 1097-1110, 2007. [Abstract],
[Full Text (pdf)]
E.D. Karagiannis, A.S. Popel. Anti-angiogenic
peptides identified in thrombospondin type I domains. Biochem. Biophys.
Res. Commun. 359: 63-69, 2007. [Abstract],
[Full Text
(pdf)]
S. Kim, R.L. Kong, A.S. Popel, M. Intaglietta, P.C.
Johnson. Temporal and spatial variations of cell-free layer width in
arterioles. Am. J. Physiol. Heart Circ. Physiol. 293:
H1526-H1535, 2007. [Abstract],
[Full Text
(pdf)]
F. Mac Gabhann, A.S. Popel. Dimerization of VEGF
receptors and implications for signal transduction: A computational study.
Biophys. Chem. 128: 125-139, 2007. [Abstract],
[Full Text
(pdf)]
F. Mac Gabhann, J.W. Ji, A.S. Popel. Multi-scale
Computational Models of Pro-angiogenic Treatments in Peripheral Arterial
Disease. Ann. Biomed. Eng. 35: 982-994, 2007. [Abstract],
[Full Text (pdf)]
M. Zhi, J.T. Ratnanather, E. Ceyhan, A.S. Popel, W.E.
Brownell. Hypotonic swelling of salicylate-treated cochlear outer hair
cells. Hear. Res. 228: 95-104, 2007. [Abstract],
[Full Text (pdf)]
B. Das, J.J. Bishop, S. Kim, H.J. Meiselman, P.C.
Johnson, A.S. Popel. Red blood cell velocity profiles in skeletal muscle
venules at low flow rates are described by the Casson model. Clin.
Hemorheol. Microcirc. 36:217-33, 2007. [Abstract],
[Full Text (pdf)]
K. Chen, A.S. Popel. Vascular and perivascular
nitric oxide release and transport: biochemical pathways of neuronal nitric
oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Free
Radic. Biol. Med. 42: 811-822, 2007. [Abstract],
[Full Text (pdf)]
F. Mac Gabhann,
A.M. Demetriades, T. Deering, J.D. Packer, S.M. Shah, E. Duh, P.A.
Campochiaro, A.S. Popel.
Protein
transport to choroid and retina following periocular injection: theoretical
and experimental study.
Ann. Biomed. Eng. 35: 615-630, 2007. [Abstract],
[Full Text (pdf)]
E.D. Karagiannis, A.S. Popel. Identification of
novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils
of type IV collagen with anti-angiogenic properties. Biochem Biophys Res
Commun. 354: 434-439, 2007. [Abstract],
[Full Text (pdf)]
B. Chung, P.C. Johnson, A.S. Popel. Application of Chimera grid to
modelling cell motion and aggregation in a narrow tube. Int. J. Numer.
Meth. Fluids 53: 105-128, 2007. [Abstract],
[Full Text (pdf)]
F.M. Gabhann, A.S. Popel. Interactions of VEGF isoforms with VEGFR-1,
VEGFR-2, and neuropilin in vivo: a computational model of human skeletal
muscle.
Am. J. Physiol. Heart. Circ. Physiol. 292: H459-H474, 2007.
[Abstract],
[Full Text (pdf)]
F. Mac Gabhann, J.W. Ji, A.S. Popel. VEGF gradients, receptor activation,
and sprout guidance in resting and exercising skeletal muscle.
J. Appl.
Physiol. 102: 722-734, 2007. [Abstract],
[Full Text (pdf)]
F. Mac Gabhann, A.S. Popel. Targeting Neuropilin-1 to Inhibit VEGF
Signaling in Cancer: Comparison of Therapeutic Approaches. PLoS Comp. Biol. 2:
1649-1662, 2006. [Abstract],
[Full Text (pdf)]
F. Mac Gabhann, J.W. Ji, A.S. Popel. Computational model of vascular
endothelial growth factor spatial distribution in muscle and pro-angiogenic
cell therapy. PLoS Comp. Biol. 2: 1107-1120, 2006. [Abstract],
[Full Text (pdf)]
S. Kim, R.L. Kong, A.S. Popel, M. Intaglietta, P.C.
Johnson. A computer-based method for determination of the cell-free layer
width in microcirculation. Microcirculation 13:
199-207, 2006. [Abstract],
[Full Text (pdf)]
A.A. Qutub, A.S. Popel. A computational model of intracellular oxygen
sensing by hypoxia-inducible factor HIF1 alpha.
J. Cell. Sci. 119: 3467-80, 2006. [Abstract],
[Full Text (pdf)]
K. Chen, A.S. Popel. Theoretical analysis of biochemical pathways of nitric
oxide release from vascular endothelial cells.
Free Radic. Biol. Med. 41: 668-680, 2006. [Abstract],
[Full Text
(pdf)]
S. Kim, A.S.
Popel, M. Intaglietta, and P.C. Johnson. Effect of erythrocyte aggregation at
normal human levels on functional capillary
density in rat spinotrapezius muscle. Am. J. Physiol. Heart Circ. Physiol.
290: H941-H947, 2006. [Abstract],
[Full Text (pdf)]
J.W. Ji, N.M. Tsoukias, D. Goldman, and A.S. Popel. A computational
model of oxygen transport in skeletal muscle for sprouting and splitting modes
of angiogenesis. J. Theor. Biol. 241: 94-108.
[Abstract],
[Full Text (pdf)]
M. Kavdia and
A.S. Popel. Venular endothelium derived NO can affect paired arteriole:
a computational model. Am. J. Physiol. Heart Circ. Physiol. 290: H716-H723,
2006.
[Abstract],
[Full Text (pdf)]
E.D. Karagiannis
and A.S. Popel. Distinct modes of collagen type I proteolysis by matrix
metalloproteinase (MMP) 2 and membrane type I
MMP during the migration of a tip endothelial cell: Insights from a
computational model. J. Theor. Biol., 238:124-145, 2006.
[Abstract],
[Full Text (pdf)]
D.R. Murdock,
S.A. Ermilov, A.A. Spector, A.S. Popel, W.E. Brownell, and B. Anvari. Effects
of chlorpromazine on mechanical properties of the outer hair cell plasma
membrane. Biophys. J. 89:4090-4095, 2005.
[Abstract],
[Full Text (pdf)]
Z. Liao, A.S.
Popel, W.E. Brownell, and A.A. Spector. Effect of voltage-dependent membrane
properties on active force generation in cochlear outer hair cell. J. Acoust.
Soc. Am. 118: 3737-3746, 2005. [Abstract],
[Full Text (pdf)]
A.A. Spector,
A.S. Popel, R.A. Eatock, and W.E. Brownell. Mechanosensitive channels in the
lateral wall can enhance the cochlear outer hair cell frequency response. Ann. Biomed. Eng.
33:991-1002, 2005. [Abstract],
[Full Text (pdf)]
F. Mac Gabhann,
M.T. Yang, A.S. Popel. Monte Carlo simulations of VEGF binding to cell surface
receptors in vitro. Biochimica et Biophysica Acta - Molecular Cell Research,
1746:95-107, 2005. [Abstract],
[Full Text (pdf)]
Z. Liao, A.S.
Popel, W.E. Brownell, and A.A. Spector. High-frequency force generation in the
constrained cochlear outer hair cell: A model study. J. Assoc. Res. Otolaryngol. (JARO),
6: 378-389, 2005. [Abstract],
[Full Text (pdf)]
P. Bagchi, P.C.
Johnson, and A.S. Popel. Computational fluid dynamic simulation of aggregation
of deformable cells in a shear flow. J. Biomech. Eng., 127:1070-1080, 2005. [Abstract],
[Full Text (pdf)]
A.S. Popel. Mathematical and Computational Models of the Microcirculation. In:
Microvascular Research: Biology and Pathology. D. Shepro, Editor-in-Chief;
P.A. D'Amore, C.M. Black, J.G.N. Garcia, D.N. Granger, C. Haudenschild, H.B.
Hechtman, R.K. Jain, and J.A. Madri, Editors, Chapter 164, pp.1123-1129,
Elsevier, New York, 2005.
Z.
Liao, A.S. Popel, W.E. Brownell, and A.A. Spector. Modeling high-frequency electromotility of cochlear outer hair cell in microchamber experiment. J. Acoust. Soc. Am.
117: 2147-2157, 2005. [Abstract],
[Full
Text (pdf)]
F.
Mac Gabhann and A.S. Popel. Differential binding of VEGF isoforms to
VEGF Receptor 2 in the presence of Neuropilin-1: a computational model.
Am. J. Physiol. (Heart Circ. Physiol.). 288(6):H2851-60, 2005. [Abstract],
[Full
Text (pdf)]
A.S. Popel and P.C. Johnson. Microcirculation and hemorheology. Ann. Rev. Fluid Mechanics,
37:43-69, 2005. [Full
Text (pdf)]
R.J. Filion and A.S. Popel. Intracoronary administration
of FGF-2: a computational model of myocardial
deposition and retention. Am. J. Physiol. (Heart Circ. Physiol.),
288:H263-279, 2005. [Abstract],
[Full
Text (pdf)]
S. Kim, A.S. Popel, M. Intaglietta, and P.C. Johnson.
Aggregate formation of erythrocytes in postcapillary venules.
Am. J.
Physiol. (Heart Circ. Physiol.), 288:H584-90, 2005. [Abstract],
[Full
Text (pdf)]
E.D. Karagiannis and A. S. Popel. A theoretical
model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and
membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase
2. J. Biol. Chem. 279:39105-39114, 2004. [Abstract],
[Full
Text (pdf)]
A.S. Popel, M. Kavdia, and N.M.
Tsoukias. Effect of hemoglobin-based blood substitutes on nitric oxide
transport: Mathematical models. In: Artificial Oxygen Carrier: Its Frontline.
K. Kobayashi, Ed. Springer Verlag,
Tokyo,
2004.
F. Mac Gabhann and A.S.
Popel. Model of competitive binding of vascular endothelial growth
factor and placental growth factor to VEGF receptors on endothelial cells. Am.
J. Physiol. (Heart Circ. Physiol.), 286:H153-164, 2004. [Abstract],
[Full
Text (pdf)]
J.J. Bishop,
P.R. Nance, A.S. Popel, M. Intaglietta, and P.C.
Johnson. Relationship between erythrocyte aggregate size and flow rate in
skeletal muscle venules. Am. J. Physiol. (Heart Circ. Physiol.), 286:H113-120,
2004. [Abstract],
[Full
Text (pdf)]
N.M. Tsoukias, M. Kavdia, and A.S.
Popel. A theoretical model of nitric oxide transport in arterioles: Frequency vs amplitude dependent control of cGMP production. Am. J. Physiol. (Heart
Circ. Physiol.), 286:H1043-H1056, 2004. [Abstract],
[Full
Text (pdf)]
M. Kavdia and A.S. Popel.
Contribution of nNOS and eNOS derived NO to microvascular smooth muscle NO
exposure. J. Appl. Physiol., 97:293-301, 2004. [Abstract],
[Full
Text (pdf)]
R.J. Filion and A.S. Popel. A reaction-diffusion
model of basic fibroblast growth factor interactions with cell surface
receptors. Ann. Biomed. Eng., 32:645-663, 2004. [Abstract],
[Full
Text (pdf)]
A.S. Popel. Biomechanical Measurements in Cells. 2004
McGraw-Hill Yearbook of Science and Technology,
McGraw-Hill, New
York, pp. 37-40.
A.A. Spector, W.E.
Brownell, and A.S. Popel. Effect of outer hair cell piezoelectricity on
high-frequency receptor potentials. J. Acoust. Soc. Am., 113:453-461, 2003.
[Abstract],
[Full
Text (pdf)]
A.S. Popel, D.
Goldman, and A. Vadapalli. Modeling of oxygen diffusion from the blood vessels
to intracellular organelles. Adv. Exp. Med. Biol., 530:485-495, 2003.
[Abstract]
M. Kavdia and A.S. Popel. Wall
shear stress differentially affects NO level in arterioles for volume
expanders & Hb-based O2 carriers. Microvasc. Res., 66:49-58,
2003. [Abstract],
[Full
Text (pdf)]
A.A. Spector, W.E. Brownell, and
A.S. Popel. Piezoelectric properties enhance outer hair cell high-frequency
response. In: The Biophysics of the Cochlea: From Molecules to Models. A.W.
Gummer, Ed., World Scientific, Singapore, 2003, pp.152-160.
N.M. Tsoukias and A.S. Popel. A
model of nitric oxide capillary exchange. Microcirculation, 10: 479-495, 2003.
[Abstract],
[Full
Text (pdf)]
M. Kavdia, R.N. Pittman and A.S. Popel.
Theoretical analysis of the effects of blood substitute affinity and cooperativity on organ oxygen transport. J. Appl. Physiol.,
93:2122-2128,
2002. [Abstract],
[Full Text
(pdf)]
J.J. Bishop, A.S. Popel, M. Intaglietta, and
P.C. Johnson. Effect of aggregation and shear rate on the dispersion of red
blood cells flowing in venules. Am. J. Physiol. (Heart Circ. Physiol.),
283:H1985-H1996, 2002. [Abstract],
[Full
Text (pdf)]
M. Sharan and A.S. Popel. A compartmental model
for oxygen transport in brain microcirculation in the presence of blood
substitutes. J. Theor. Biol., 216: 479-500, 2002. [Abstract],
[Full
Text (pdf)]
N.M. Tsoukias and A.S. Popel. Erythrocyte
consumption of nitric oxide in the presence and absence of plasma-based
hemoglobin. Am. J. Physiol. (Heart Circ. Physiol.), 282: H2265-2277, 2002. [Abstract],
[Full
Text (pdf)]
M. Kavdia,
N.M. Tsoukias, and A.S. Popel. A model of
nitric oxide diffusion in an arteriole: Impact of hemoglobin-based blood
substitutes. Am. J. Physiol. (Heart Circ. Physiol.), 282: H2245-2253, 2002. [Abstract],
[Full
Text (pdf)]
A.A. Spector, M. Ameen, P.G. Charalambides, and
A.S. Popel. Nanostructure, effective properties, and deformation pattern of
the cochlear outer hair cell cytoskeleton. J. Biomech. Eng., 124:180-187,
2002. [Abstract],
[Full
Text (pdf)]
A. Vadapalli, D. Goldman, and A.S. Popel.
Calculations of oxygen transport by red blood cells and hemoglobin solutions
in capillaries. Artificial Cells, Blood Substitutes, Immobilization
Biotechnology, 30: 157-188, 2002. [Abstract],
[Full
Text (pdf)]
D.M. Wootton, A.S. Popel, and B.R. Alevriadou.
An experimental and theoretical study on the dissolution of mural fibrin clots
by tissue-type plasminogen activator. Biotechnology and Bioengineering,
77: 405-419, 2002. [Abstract],
[Full
Text (pdf)]
M. Sharan and A.S. Popel. A two-phase model for
blood flow in narrow tubes with increased viscosity near the wall. Biorheology,
38: 415-428, 2001. [Abstract],
[Full
Text (pdf)]
J.J. Bishop, A.S. Popel, M. Intaglietta, and P.C. Johnson. Rheological
effects of red blood cell aggregation in the venous network: a review of
recent studies. Biorheology, 38:263-274, 2001. [Abstract],
[Full
Text (pdf)]
W.E. Brownell, A.A. Spector, R.M. Raphael, and A.S. Popel. Micro- and nanomechanics of the cochlear outer hair cell. Annu. Rev. Biomed.
Eng., 3:
169-194, 2001.[Abstract],
[Full
Text (pdf)]
J.J. Bishop, A.S. Popel, M. Intaglietta, and P.C. Johnson. Effects of
erythrocyte aggregation and venous network geometry on red blood cell axial
migration. Am. J. Physiol. (Heart Circ. Physiol.), 281: H939-950, 2001. [Abstract],
[Full
Text (pdf)]
J.J. Bishop, P.R. Nance, A.S. Popel, M. Intaglietta, and P.C. Johnson.
Erythrocyte margination and sedimentation in skeletal muscle venules. Am. J.
Physiol. (Heart Circ. Physiol.), 281: H951-958, 2001. [Abstract],
[Full
Text (pdf)]
D. Goldman and A.S. Popel. A computational study of the effect of vasomotion on oxygen transport from capillary networks. J. Theor. Biol.
209:189-199, 2001. [Abstract],
[Full
Text (pdf)]
A.A. Spector, M. Ameen, and A.S. Popel. Simulation of motor-driven outer
hair cell electromotility. Biophys. J., 81:11-24, 2001. [Abstract],
[Full
Text (pdf)]
J.J. Bishop, P.R. Nance, A.S. Popel, M. Intaglietta, and P.C. Johnson.
Effect of erythrocyte aggregation on velocity profiles in skeletal muscle venules. Am. J. Physiol. (Heart Circ. Physiol.)
280: H222-H236, 2001. [Abstract],
[Full
Text (pdf)]
D. Goldman and A.S. Popel. A computational study of the effect of capillary
network anastomoses and tortuosity on oxygen transport. J. Theor. Biol.,
206:181-194, 2000. [Abstract],
[Full
Text (pdf)]
C.D. Eggleton, A. Vadapalli, T.K. Roy, and A.S. Popel. Calculations of intracapillary oxygen tension distributions in muscle. Math. Biosci.,
167:123-143, 2000. [Abstract],
[Full
Text (pdf)]
J.J. Bishop, P.R. Nance, A.S. Popel, M. Intaglietta, and P.C. Johnson.
Diameter changes in skeletal muscle venules during arterial pressure
reduction. Am. J. Physiol. (Heart Circ. Physiol.) 279: H47-H57, 2000. [Abstract],
[Full
Text (pdf)]
R.M. Raphael, A.S. Popel, and W.E. Brownell. A membrane bending model of
outer hair cell electromotility. Biophys. J., 78: 2844-2862, 2000. [Abstract],
[Full
Text (pdf)]
A.R. Vadapalli, R.N. Pittman, and A.S. Popel. Estimating oxygen transport
resistance of the microvascular wall. Am. J. Physiol. (Heart Circ. Physiol),
279: H657-H671, 2000. [Abstract],
[Full
Text (pdf)]
B. Das, P.C. Johnson, and A.S. Popel. Computational fluid dynamic studies
of leukocyte adhesion effects on non-Newtonian blood flow through microvessels. Biorheology,
37: 239-258, 2000. [Abstract],
[Full
Text (pdf)]
A.S. Popel and R.N. Pittman. Mechanics and transport in the
microcirculation. Handbook of Biomedical Engineering, Chapter 31, J. Bronzino,
Ed., CRC Press, Boca Raton, 2nd edition, 2000, pp. 31.1-31.12.
J.T. Ratnanather, A.S. Popel, and W.E. Brownell. An analysis of the
hydraulic conductivity of the extracisternal space of the cochlear outer hair
cell. J. Math. Biol., 40: 372-382, 2000. [Abstract],
[Full
Text (pdf)]
