ESAK LEE (ISAAC)

Education

M.S. in Pharmacy, Seoul National University, South Korea, 2008
B.S. in Chemical and Biological Engineering, Seoul National University , South Korea, 2006

Honors

[1] Invited talk, Breast Cancer Seminar (Sidney Kimmel Comprehensive Cancer Center), Johns Hopkins University, USA, 2013

[2] Mogam Scholarship, Mogam Science Scholarship Foundation, South Korea, 2012

[3] 'Runner up' Award, Safeway Breast Cancer Symposium, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, USA, 2012

[4] Brain Korea 21 Scholarship, Korea Research Foundation, South Korea, 2008

[5] Merit-based scholarship, Seoul National University, South Korea, 2002-2006

Research Interests

I am focusing on molecular mechanisms of breast cancer metastasis by looking into the roles of angiocrine and lymphangiocrine factors in normal or cancerous condition. I am also interested in the development of anti-lymphangiogenic and anti-angiogenic peptides to target tumor growth and metastasis.

Publications

[1] Lee, E., Pandey, N.B., Popel, A.S., "Breast cancer cells educate lymphatic endothelial cells within pre-metastatic niches to promote metastasis" (in revision for the Nature Communications)

[2] Lee, E., Pandey, N.B., Popel, A.S., "Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model."Clin Exp Metastasis 2013 Aug 21

[3] Lee, E., Koskimaki, J.E., Pandey, N.B., Popel, A.S., "Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A." *Neoplasia, 15(2):112-24 (*Cover article)

[4] Koskimaki, J.E.*, Lee, E.*, Chen, W., Rivera, C.G., Rosca, E.V., Pandey, N.B., Popel, A.S., "Synergy between a collagen IV mimetic peptide and a somatotropin-domain containing peptide as angiogenesis and lymphangiogenesis inhibitors." Angiogenesis, 16(1):159-70, 2013 (*Equal contribution)

[5] Koskimaki, J.E., Rosca, E.V., Rivera, C., Lee, E., Chen, W., Pandey, N.B., Popel, A.S., "Serpin-derived peptides are anti-angiogenic and suppress breast tumor growth in vivo." Transl Oncol, 5(2):92-7, 2012

[6] Lee, E., Rosca, E.V., Pandey, N.B., Popel, A.S., "Small peptides derived from somatotropin domain-containing proteins inhibit blood and lymphatic endothelial cell proliferation, migration, adhesion and tube formation." Int J Biochem Cell Biol, 43:1812-21, 2011

[7] Lee, E., Kim, Y.S., Bae, S.M., Kim, S.K., Jin, S., Chung, S.W., Lee, M., Jeon, O.C., Park, R.W., Kim, I.S., Byun, Y., Kim, S.Y., "Polyproline-type helical-structured low-molecular weight heparin (LMWH)-taurocholate conjugate as a new angiogenesis inhibitor." Int J Cancer, 124: 2755-65, 2009

[8] Chu, L.H., Lee, E., Bader, J.S., Popel, A.S., Angiogenesis interactome and time course microarray data reveal the distinct activation pattern of receptor tyrosine kinases on endothelial cells, under review

Hobbies

Guitar, classical music, movie

Home town

Seoul, South Korea